Cross Lab
Research SummaryWe are interested in the molecular mechanisms of kinesin molecular motors and microtubules. Our work is discovery science, aiming to inform the development of new drug therapies for a range of global health problems that includes malaria, cancer, cardiovascular disease, Alzheimers and reproductive disease. As part of this mission, we develop new optical microscopes.
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Selected PublicationsKatsuki, M., Drummond, D.R., Cross, R.A. (2014) Ectopic A-lattice seams destabilize microtubules. Nature Communications 5, doi: 10.1038/ncomms4094 PubMed Wollman, A.J., Sanchez-Cano, C., Carstairs, H.M., Cross, R.A., Turberfield, A.J. (2013) Transport and self-organization across different length scales powered by motor proteins and programmed by DNA. Nature Nanotechnology PubMed Grant, B.J., Gheorghe, D., Zheng,W., Alonso, M., Huber, G., Dlugosz,M., McCammon, J.A. and Cross, R.A. (2011) DesGeorges, A., Katsuki, M., Drummond, D.R., Osei, M., Cross, R.A. and Amos, L.A. (2008) Alonso, M.C., Drummond, D.R., Kain, S., Hoeng, J., Amos, L.A. and Cross, R.A. (2007) An ATP-gate controls tubulin binding by the tethered head of kinesin-1. Science. 316:120-3. Pubmed |