Warwick-I is a forum for sharing information on all things imaging, helping to strengthen and build new collaborative links within the Warwick Imaging community.

If you would like to be included as an imaging laboratory or resource than please contact us.

Dr John Aston (Department of Statistics)

Interests include Computational Statistics, Statistics for Neuroimaging (Human Brain Mapping), Time Series Analysis, Functional Data Analysis, Seasonal Adjustment, Markov Chain Pattern Distribution Theory, Statistical Phonetics.

Dr Andrew Blanks (Warwick Medical School)

I am interested in the function of cellular heterogeneity in complex tissues and the correlation of physiological data with molecular biology with particular consideration given to levels of biological organisation. I am also interested in mammalian parturition, and am part of a national collaboration to assemble a computational model of the pregnant human uterus based on accurate biophysical, molecular and anatomical parameters.

Dr Till Bretschneider (Warwick Systems Biology Centre)

My main research interest is to understand principles of self-organisation involved in the motion of animal cells. We use a combined approach based on computational modelling and quantitative imaging to address problems ranging from the multicellular to the molecular level. The development of imaging software for the automated analysis of large cell populations is becoming increasingly important, while the analysis of high-throughput video-microscopy data at the single cell level will not only be applied to problems of cell motion, but also to the analysis of temporal gene expression profiles.

Professor Jan Brosens (Warwick Medical School)

My research centres on the role of steroid hormone signalling in the human endometrium, especially in the context of prevalent reproductive disorders, such as infertility, endometriosis and endometrial cancer. My major translational interest is focused on improving the management of miscarriage, the most common complication of pregnancy.

Professor Nigel Burroughs (Warwick Mathematics Institute and Warwick Systems Biology Centre)

I have very broad interests in applying physical science techniques (mathematics, physics, statistics) to biological and medical problems . I am predominantly stimulated by challenges in dynamic phenomena, either developing models of mechanism, or analysing data to demonstrate or discover mechanisms. This can be at a range of scales, from the molecular, eg a signalling mechanism, to the ecological, a predator-prey system, and use a variety of data types, 3+1D fluorescence data, omics data, biochemical data. I use a variety of techniques from mathematics and statistics, including dynamical systems, graph theory, stochastic modelling and the highly flexible range of Markov chain Monte Carlo techniques.

Dr Nick Carter (Warwick Medical School)

I research in the field of single molecule mechanics, but I build microscopes as well as use them. My microscope projects include laser tweezers, TIRF, darkfield, DIC and SIM. I am also designing the Warwick Open Source Microscope.

Dr Joanna Collingwood (School of Engineering)

Our primary focus is on imaging and quantifying transition metal ion distribution in the human brain, with particular application to identifying change in neurodegenerative disorders. We measure the effects of regional brain iron changes on Magnetic Resonance Imaging (MRI) to explore biomarker potential. We use a variety of analytical techniques, including high resolution MRI, synchrotron X-ray microfocus spectroscopy, and magnetometry to characterize the distribution and form of trace metals in tissues and disease-related protein aggregates.

Dr Sonia Correa (School of Life Sciences)

My research interests are centred on the understanding of the molecular mechanisms involved in the internalization of AMPA receptors from synapses during long-term depression. As trafficking and phosphorylation of certain proteins are associated events during plasticity, I am particularly interested on the role played by mitogen-activated protein kinase (MAPK) signalling pathways during synaptic plasticity.

Professor Rob Cross (Warwick Medical School)

I am interested in mechanochemical coupling in molecular motors, and more generally in mechanotransduction and in the principles and possibilities of motorised molecular self-organisation in biological systems and in synthetic nanosystems. I focus specifically on the mechanochemistry of kinesins and microtubules. I am interested in particular in how kinesin motors and their microtubule tracks read and feed back upon each other's organization and mechanochemical status, both directly, and via sets of associated proteins.

Professor David Evans (School of Life Sciences)

Professor Jianfeng Feng (Centre for Scientific Computing)

The general theme of my research is Computational Biology: abstract and biophysical models of single neuron, neural networks, stochastic and nonlinear dynamics, data mining and mathematical physics.

Professor Bruno Frenguelli (School of Life Sciences)

My laboratory is interested in several aspects of the brain: its ability to learn and remember, its vulnerability to stroke, epilepsy and injury and the role that the purines ATP and adenosine, play in these processes. We use a combination of electrophysiological, pharmacological, biochemical, biosensor and imaging techniques

Dr Lorenzo Frigerio (School of Life Sciences)

My main interest is the study of the intracellular targeting of proteins in the plant secretory pathway

Dr Markus Kirkilonis (Warwick Mathematics Institute)

Mathematical biology, dynamic network models, complex systems, numerical analysis, pattern formation, physiologically structured Population models, (monotone) dynamical systems We study complex systems with the help of mathematical modelling and simulation. My field of application is mainly biology, both at the molecular systems level and beyond, from cell biology to physiology and ecology. We are interested in both non-spatial modelling (reaction systems, networks) and spatially explicit models. Our mathematical methods are mainly partial differential equations, integral equations, dynamical systems, graph theory, and numerical analysis.

Dr Graham Ladds (Warwick Medical School)

My interest is in the modelling of spatiotemporal control of cell signalling.

Dr Andrew McAinsh (Warwick Medical School)

We are focused on trying to understand how the coupled mechanical system of chromosomes, kinetochores, spindle poles, microtubules and molecular motors are able to self-organize into the mitotic spindle and accurately segregate sister chromatids in anaphase. We are particularly interested in deciphering how kinetochores form strong, but flexible attachments to the dynamic plus-end of spindle microtubules and generate the forces necessary to power chromosome movement.

Professor Jonathan Millar (Warwick Medical School)

My laboratory is primarily interested in the molecular mechanisms that ensure the faithful separation of sister chromatids in eukaryotic cells. We are also interested in the signalling mechanisms by which external cues such as nutrient limitation, environmental stress and mating pheromone are perceived by the cell and how these factors influence cell cycle progression.

Dr Tom Nichols (Warwick Manufacturing Group and Department of Statistics)

I am a Principal Research Fellow and Head of Neuroimaging Statistics at the Institute for Digital Healthcare, holding a joint position between Warwick Manufacturing Group & the Department of Statistics. My research focuses on modelling and inference of neuroimaging data, including PET, fMRI & M/EEG.

Dr Yuriy Pankratov (School of Life Sciences)

My research is focused on the role of neuronal-glial communication in brain disorders and brain ageing with particular focus pathological signaling mediated by astroglial NMDA and P2X receptors.

Dr Nasir Rajpoot (Department of Computer Science)

My current research interests lie in the areas of biomedical image analysis (Bioimage Computing, Computational Histopathology), wavelet representations (Planelets, Polar cosine transform), texture analysis (WaveTex, Phase Gradients, VillageFinder)computer vision, and image/video denoising (Miltilateral Filtering).

Dr Magnus Richardson (Warwick Systems Biology Centre)

Professor Peter Sadler (Department of Chemistry)

My interest is in the chemistry of metals in medicine (bioinorganic chemistry, inorganic chemical biology and medicine). I also work on the design and chemical mechanism of action of therapeutic metal complexes, including organometallic arene anticancer complexes, photoactivated metal anticancer complexes (for photochemotherapy), metallomacrocycles as antivirals and stem-cell-mobilising agents, and metalloantibiotics.

Dr Richard Savage (Warwick Systems Biology Centre)

My research interests centre on the use of probabilistic (Bayesian) methods for extracting scientific knowledge from large, potentially complex data-sets.

Dr Anatoly Shmygol (Warwick Medical School)

My research is concerned with the mechanisms of electrogenesis, autorhythmicity and Ca signalling in the myometrium. We use patch clamp, sharp microelectrodes, multidimensional digital imaging and confocal microscopy combined with mathematical modelling to investigate the signalling pathways linking the rise in intracellular Ca to the activation of the plasma membrane ion channels.

Dr Corrine Smith (School of Life Sciences)

The research in my laboratory involves investigating the structure and mechanism of clathrin coated vesicle formation during clathrin-mediated endocytosis using a range of structural and biophysical techniques.

Dr Paul Squires (School of Life Sciences)

My research interests include elucidating sub-cellular mechanism that regulate insulin secretion and action. A common avenue for both projects is the role of cell-to-cell communication in synchronising Ca2+-transients and function between cells of both the nephron and pancreatic islet.

Dr Anne Straube (Warwick Medical School)

My research is to understand the mechanochemical processes underlying directional cell migration and differentiation. We focus on the mechanisms that generate specific microtubule arrays and study the dynamic interactions of microtubules with the cell cortex during cell shape changes. We are using live-cell imaging and biochemical approaches paired with RNA interference and target protein mutagenesis to analyse structure-function relationships of motor proteins, structural MAPS and the +tip complex.

Dr Hugo van den Berg (Warwick Mathematics Institute and Warwick Systems Biology Centre)

Present research is aimed at elucidating the relationships between immune response efficacy and the statistical distributions of T cell specificities among the naive repertoire and among T cell populations which respond to given antigenic challenges. At the heart of the theory is a model of T cell receptor triggering kinetics, which relates T cell specificity to the distribution of antigenic peptide-presenting MHC molecules on the conjugate cell. This kinetic model allows us to describe how measures for T cell specificity functionally depend upon MHC-presentation levels.

Dr Mark Wall (School of Life Sciences)

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