PET-Neck
A multicentre randomised phase III trial comparing PET-CT guided watch and wait policy versus planned neck dissection for the management of locally advanced (N2/N3) nodal metastases in patients with head and neck squamous cancer
Randomisation opening times over the holiday season: The randomisation service will close on Thursday 22nd December at 12 noon and re-open on Tuesday 3rd January 2012 at 9 am.
Acknowledgements
We wish to acknowledge that PET-NECK is funded by the UK Department of Health, Health Technology Assessment Programmme.
Any opinions expressed here are those of the authors and do not necessarily reflect those of the UK National Health Serivce or the Department of Health.
Aim of the Project
To compare the efficacy of a PET-CT guided watch and wait policy with the current practice of planned neck dissection on overall survival, disease-specific survival, recurrence, quality of life and cost-effectiveness in the management of advanced (N2 or N3) nodal metastasis in patients treated with chemo/radiotherapy (CRT) for their head and neck squamous carcinoma (HNSCC) primary.
Ethical Approval
Oxfordshire REC A
Project Schedule
Start Date: 01/04/2007, End Date: 31/03/2013
Lead Investigators
| Name | Establishment | Role | Speciality |
| Mr Hisham Mehanna | University Hospitals Coventry and Warwickshire | Chief Investigator | Head and Neck Surgeon |
| Professor Janet Dunn | University of Warwick | Non-clinical Lead applicant | Professor of Clinical Trials and Head of Cancer Trials Deputy Director WMS Clinical Trials Unit |
| Professor Chris McCabe | University of Leeds | Co-applicant | Health Economics |
| Mrs Sheila Fisher | University of Leeds | Co-applicant | Maxillofacial Surgery |
| Dr Chris Nutting | Royal Marsden NHS Foundation Trust | Co-applicant | Clinical Oncology |
| Dr Wai-Lup Wong | Mount Vernon Hospital | Co-applicant | Radiology |
| Professor Ken Maclennan | Leeds General Infirmary | Co-applicant | Histopathology |
Project team
| Name | Establishment | Role |
| Joy Rahman | University of Warwick | Trial Co-Ordinator |
| Chris McConkey | University of Warwick | Statistician |
| Dharmesh Patel | University of Warwick | Data Input Clerk |
| June Jones | University Hospitals Coventry and Warwickshire |
Research Nurse |
Project collaborators
| Head and Neck Centre |
| Heart of England NHS Foundation Trust |
Publications/Presentations to Date
PET-NECK: Setting up a collaborative clinical trial in a rare disease site. Society of Clinical Trials, May 2008.
Key people
- Prof Janet Dunn
Professor of Clinical Trials and Head of Cancer Trials Deputy Director WMS Clinical Trials Unit - Mr Hisham Mehanna, Consultant Head-Neck and Thyroid Surgeon
- Joy Rahman Clinical Trial Coordinator
Enquiries contact
- Joy Rahman Clinical Trial Coordinator
- Dharmesh Patel Data Input Clerk
