Job Title
Assistant Professor
Department
WMS - Translational Medicine
Phone
+44 (0)2476 528376
Research Interests
Combining the structure function analyses of a range of GPCRs with their clinical and biological relevance to answer fundamental questions about cell signalling, drug response and pharmacology. Key areas of interest include a particular clinical emphasis on orexins and their receptors, as well as a general approach to elucidate the shared mechanisms of action between the sub-families of G-protein coupled receptors. I also have an interest in neuropsychopharmacology and the genetics of psychiatric disease.
- Kitchen, Philip, Day, Rebecca E., Taylor, Luke H. J., Salman, Mootaz M., Bill, Roslyn M., Conner, Matthew T., Conner, Alex C., 2015. Identification and molecular mechanisms of the rapid tonicity-induced relocalization of aquaporin 4. Journal of Biological Chemistry, 290, pp. 16873-16881
- Day, Rebecca E., Kitchen, Philip, Owen, David S., Bland, Charlotte, Marshall, Lindsay, Conner, Alex C., Bill, Roslyn M., Conner, Matthew T., 2014. Human aquaporins : regulators of transcellular water flow. Biochimica et Biophysica Acta (BBA) - General Subjects, 1840 (5), pp. 1492-1506
- Barwell, James, Wheatley, Mark, Conner, Alex C., Taddese, Bruck, Vohra, Shabana, Reynolds, Christopher A., Poyner, David R., 2013. The activation of the CGRP receptor. Biochemical Society Transactions, 41 (1), pp. 180-184
- Woolley, Michael J., Watkins, Harriet A., Taddese, Bruck, Karakullukcu, Z. Gamze, Barwell, James, Smith, Kevin J., Hay, Debbie L., Poyner, David, Reynolds, Christopher A., Conner, Alex C., 2013. The role of ECL2 in CGRP receptor activation : a combined modelling and experimental approach. Journal of The Royal Society Interface, 10 (88)
- Conner, Alex C., Bill, Roslyn M., Conner, Matthew T., 2013. An emerging consensus on aquaporin translocation as a regulatory mechanism. Molecular Membrane Biology, 30 (1), pp. 101-112
- Barwell, James, Woolley, Michael J., Wheatley, Mark, Conner, Alex C., Poyner, David R., 2012. The role of the extracellular loops of the CGRP receptor, a family B GPCR. Biochemical Society Transactions, Vol.40 (No.2), pp. 433-437
- Vohra, Shabana, Taddese, Bruck, Conner, Alex C., Poyner, David, Hay, Debbie L., Barwell, James, Reeves, Philip J., Upton, Graham J. G., Reynolds, Christopher A., 2012. Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. Journal of The Royal Society Interface, 10 (79)
- Conner, M. T., Conner, Alex C., Bland, C. E., Taylor, Luke H. J., Brown, J. E. P., Parri, H. R., Bill, R. M., 2012. Rapid aquaporin translocation regulates cellular water flow : Mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel. Journal of Biological Chemistry, Vol.287 (No.14), pp. 11516-11525
- Barwell, James, Conner, Alex C., Poyner, David R., 2011. Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. Biochimica et Biophysica Acta - Molecular Cell Research, Vol.1813 (No.10), pp. 1906-1916
- Ramanjaneya, Manjunath, Conner, Alex C., Brown, James E. P., Chen, Jing, Digby, Janet E., Barber, T. M., Lehnert, Hendrik, Randeva, Harpal S., 2011. Adiponectin (15?36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells : role of AMPK and MAPK kinase pathways. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1813 (5), pp. 802-809
- Brown, James E. P., Onyango, David J., Ramanjaneya, Manjunath, Conner, Alex C., Patel, Snehal T., Dunmore, Simon J., Randeva, Harpal S., 2010. Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells. Journal of Molecular Endocrinology, Vol.44 (No.3), pp. 171-178
- Brown, James E. P., Conner, Alex C., Digby, Janet E., Ward, Kenya L., Ramanjaneya, Manjunath, Randeva, Harpal S., Dunmore, Simon J., 2010. Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin. Peptides, Vol.31 (No.5), pp. 944-949
- Conner, Matthew T., Conner, Alex C., Brown, James E. P., Bill, Roslyn M., 2010. Membrane trafficking of aquaporin 1 is mediated by protein kinase C via microtubules and regulated by tonicity. Biochemistry, Vol.49 (No.5), pp. 821-823
- Ramanjaneya, Manjunath, Conner, Alex C., Chen, Jing, Kumar, Prashanth, Brown, James E. P., Joehren, Olaf, Lehnert, Hendrik, Stanfield, Peter R., Randeva, Harpal S., 2009. Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells : diverse roles for orexins A and B. Journal of Endocrinology, Vol.202 (No.2), pp. 249-261
- Tang, Jiyou, Chen, J. (Jing), Ramanjaneya, Manjunath, Punn, Anu, Conner, Alex C., Randeva, Harpal S., 2008. The signalling profile of recombinant human orexin-2 receptor. Cellular Signalling, Vol.20 (No.9), pp. 1651-1661
- Kissling, Christian, Retz, Wolfgang, Wiemann, Stefan, Coogan, Andrew N., Clement, R. Marc, Hünnerkopf, Regina, Conner, Alex C., Freitag, Christine M., Rösler, Michael, Thome, Johannes, 2008. A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol.147B (No.3), pp. 333-338
- Conner, Alex C., Kissling, Christian, Hodges, Edward, Huennerkopf, Regina, Clement, R. Marc, Dudley, E. (Edward), Freitag, Christine M., Roesler, Michael, Retz, Wolfgang, Thome, Johannes, 2008. Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol.147B (No.8), pp. 1476-1480
- Conner, Matthew, Hicks, Matthew R., Dafforn, Tim, Knowles, Timothy J., Ludwig, Christian, Staddon, Susan, Overduin, Michael, Guenther, Ulrich L., Thome, J. (Johannes), Wheatley, Mark, Dr., Poyner, David R., Conner, Alex C., 2008. Functional and biophysical analysis of the C-terminus of the CGRP-receptor ; a family B GPCR. Biochemistry, Vol.47 (No.32), pp. 8434-8444
- Ramanjaneya, Manjunath, Conner, Alex C., Chen, J. (Jing), Stanfield, Peter R., Randeva, Harpal S., 2008. Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells. Endocrinology, 149 (8), pp. 4106-4115
- Parrott, A. C., Lock, J., Conner, Alex C., Kissling, C., Thome, J., 2008. Dance clubbing on MDMA and during abstinence from Ecstasy/MDMA : prospective neuroendocrine and psychobiological changes. Neuropsychobiology, Vol.57 (No.4), pp. 165-180
- Barwell, James, Wootten, Denise, Conner, Alex C., Simms, John, Wheatley, Mark, Poyner, David, 2009. Ligand binding and activation of the CGRP receptor. Turkish Society of Molecular Medicine Third International Congress of Molecular Medicine, Istanbul, Turkey, May 5?8, 2009, Published in IUBMB Life, pp. 289-289
- Walker, Christopher S., Conner, Alex C., Poyner, David R., Hay, Debbie L., 2010. Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends in Pharmacological Sciences, Elsevier Ltd, pp. 476-483
- Poyner, David R., Hay, Debbie L., Conner, Alex C., 2009. CGRP receptor antagonists: design and screening. EXPERT OPINION ON DRUG DISCOVERY, INFORMA HEALTHCARE, pp. 1253-1265
Title | Funder | Award start | Award end |
---|---|---|---|
The second extracellular loop of the CGRP receptor: A docking site for vasoprotective ligands | British Heart Foundation | 01 Mar 2013 | 29 Feb 2016 |