RESEARCH PROFILE

Our research concerns cell communication. We wish to discover how cells talk to each other and how we can influence what they say. Most of the work is performed in the fission yeast Schizosaccharomyces pombe as this provides a simple, genetically tractable, organism in which to study the communication process.

CURRENT RESEARCH PROJECTS

• The new Centre of Mechanochemical Cell Biology, Funded by: Wolfson Foundation, Project Start Date: 01/01/2010 Project End Date: 31/12/2012
  
  

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SELECTED PUBLICATIONS

• Smith, B., Hill, C., Godfrey, E. L., Rand, D., Van den Berg, H., Thornton, S., Hodgkin, M., Davey, J. and Ladds, G.(2009) 'Dual positive and negative regulation of GPCR signaling by GTP hydrolysis' Cellular Signalling 21 (7), 1151 - 1160 (0898-6568) [article]
• Ladds, G., Zervou, S., Vatish, M., Thornton, S. and Davey, J.(2009) 'Regulators of G protein signalling proteins in the human myometrium' European Journal Of Pharmacology 610 (1-3), 23 - 28 (0014-2999) [article]
• Hill, C., Goddard, A., Ladds, G. and Davey, J.(2009) 'The cationic region of Rhes mediates its interactions with specific G beta subunits' Cellular Physiology and Biochemistry 23 (1-3), 1 - 8 (1015-8987) [article]
• Hill, C., Brownlie, Z., Davey, J., Milligan, G. and Ladds, G.(2008) 'Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity' Cellular Signalling 20 (2), 323 - 336 (0898-6568)
• Ladds G, Goddard A, Hill C, Thornton S, Davey J(2007) 'Differential effects of RGS proteins on Galphaq and Galpha11 activity' Cellular Signalling 19 103 - 113 (0898-6568)

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Conferences