Publications

Kou B, Zhang J, Singer DRJ. Effects of cyclic strain on endothelial cell apoptosis and tubulogenesis are dependent on ROS production via NAD(P)H subunit p22phox. Microvascular Research. 2009;77:125-33.

Kou B, Zhang J, Singer DRJ. Xanthine Oxidase Interaction with Vascular Endothelial Growth Factor in Human Endothelial Cell Angiogenesis. Microcirculation. 2008;15:251-267. doi: 10.1080/10739680701651495

CJ Kelsall, AH Chester, P Sarathchandra, DRJ Singer. Expression and localization of C-type natriuretic peptide in human vascular smooth muscle cells. Vascular Pharmacology 2006;Dec;45(6):368-73. Epub 2006 Jun 22.

Kou B, Vatish M, Singer DR. Effects of Angiotensin II on human endothelial cells survival signalling pathways and angiogenic response. Vascul Pharmacol. 2007 Aug 11; [Epub ahead of print] doi:10.1016/j.vph.2007.06.011

Hussain MB, Puntmann VO, Mayr M, Khong T, Singer DRJ. The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease. Vascul Pharmacol. 2006 Jun 14; [Epub ahead of print] 

Puntmann VO, Hussain MB, Mayr M, Xu Q, Singer DRJ. Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease. Vascul Pharmacol. 2005 Oct;43(4):277-82. Epub 2005 Oct 21.

Kelsall CJ, Chester AH, Amrani M, Singer DR. C-type natriuretic peptide relaxes human coronary artery bypass grafts preconstricted by endothelin-1. Ann Thorac Surg. 2005 Oct;80(4):1347-51.

Hussain MB, Singhal S, Markus HS, Singer DRJ. Abnormal vasoconstrictor responses to angiotensin II and noradrenaline in isolated small arteries from patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Stroke. 2004 Apr;35(4):853-8. Epub 2004 Mar 4.

Singh N, Graves J, Taylor PD, MacAllister RJ, Singer DRJ. Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects. Cardiovasc Res. 2002 Oct;56(1):118-25. 

Puddy VF, Amirmansour C, Williams AF, Singer DR. Plasma brain natriuretic peptide as a predictor of haemodynamically significant patent ductus arteriosus in preterm infants. Clin Sci (Lond). 2002 Jul;103(1):75-7. 

Buckley MG, Jenkins GH, Mitchell AG, Yacoub MH, Singer DRJ. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci (Lond). 2000 Nov;99(5):467-72.

Buckley MG, Yacoub MH, Singer DRJ. Investigation of the plasma concentrations and circulating forms of BNP and ANP in orthotopic cardiac transplant recipients. J Hum Hypertens. 1998 Dec;12(12):825-6.

Missouris CG, Grouzmann E, Buckley MG, Barron J, MacGregor GA, Singer DRJ. How does treatment influence endocrine mechanisms in acute severe heart failure? Effects on cardiac natriuretic peptides, the renin system, neuropeptide Y and catecholamines. Clin Sci (Lond). 1998 Jun;94(6):591-9.

Buckley MG, Marcus NJ, Yacoub MH, Singer DRJ. Prolonged stability of brain natriuretic peptide: importance for non-invasive assessment of cardiac function in clinical practice. Clin Sci (Lond). 1998 Sep;95(3):235-9.

Singer DRJ, Markandu ND, Buckley MG, Miller MA, Sagnella GA, MacGregor GA. Contrasting endocrine responses to acute oral compared with intravenous sodium loading in normal humans. Am J Physiol. 1998 Jan;274(1 Pt 2):F111-9. 

Missouris CG, Barley J, Jeffery S, Carter ND, Singer DRJ, MacGregor GA. Genetic risk for renal artery stenosis: association with deletion polymorphism in angiotensin 1-converting enzyme gene. Kidney Int. 1996 Feb;49(2):534-7.

Sagnella GA, Markandu ND, Buckley MG, Miller MA, Blackwood A, Singer DRJ, MacGregor GA. Hormonal and renal responses to neutral endopeptidase inhibition in normal humans on a low and on a high sodium intake. Eur J Clin Invest. 1995 Mar;25(3):165-70.

Ationu A, Burch M, Singer D, De Leval M, Whitehead B, Carter N. Ventricular expression and circulating levels of insulin-like growth factor I in heart transplant recipients. Clin Sci (Lond). 1995 Jul;89(1):53-7.

Wolfensberger TJ, Singer DRJ, Freegard T, Markandu ND, Buckley MG, MacGregor GA. Evidence for a new role of natriuretic peptides: control of intraocular pressure. Br J Ophthalmol. 1994 Jun;78(6):446-8.

Ationu A, Hassall C, Moules E, Patton M, Singer DRJ, Burnstock G, Carter ND. Secretion of atrial and brain natriuretic peptides from human cardiac atrial explants in culture: effect of dynorphin. Cardioscience. 1994 Jun;5(2):81-5.

Singer DRJ, Markandu ND, Buckley MG, Miller MA, Sagnella GA, Lachno DRJ, Cappuccio FP, Murday A, Yacoub MH, MacGregor GA. Blood pressure and endocrine responses to changes in dietary sodium intake in cardiac transplant recipients. Implications for the control of sodium balance. Circulation. 1994 Mar;89(3):1153-9.

Singer DRJ, Markandu ND, Morton JJ, Miller MA, Sagnella GA, MacGregor GA. Angiotensin II suppression is a major factor permitting excretion of an acute sodium load in humans. Am J Physiol. 1994 Jan;266(1 Pt 2):F89-93.

Ationu A, Hassall C, Moules E, Patton M, Singer DRJ, Burnstock G, Carter ND. Secretion of atrial and brain natriuretic peptides from human cardiac atrial explants in culture: effect of dynorphin. Cardioscience. 1994 Jun;5(2):81-5.

Ationu A, Hassall CJ, Moules E, Mascaro G, Carter ND, Burnstock G, Singer DRJ. Expression of insulin-like growth factor-1 by human ventricular explants in culture. J Hum Hypertens. 1993 Aug;7(4):407-9.

Ationu A, Sorensen K, Whitehead B, Singer D, Burch M, Carter ND. Ventricular expression of brain natriuretic peptide gene following orthotopic cardiac transplantation in children--a three year follow up. Cardiovasc Res. 1993 Dec;27(12):2135-9.

Ationu A, Hassall CJ, Moules E, Mascaro G, Carter ND, Burnstock G, Singer DRJ. Expression of insulin-like growth factor-1 by human ventricular explants in culture. J Hum Hypertens. 1993 Aug;7(4):407-9.

Ationu A, Singer DRJ, Smith A, Elliott M, Burch M, Carter ND. Studies of cardiopulmonary bypass in children: implications for the regulation of brain natriuretic peptide. Cardiovasc Res. 1993 Aug;27(8):1538-41.

Ationu A, Sorensen K, Whitehead B, Singer D, Carter N. Ventricular expression and circulating levels of immunoreactive dynorphin in heart transplant recipients. Clin Sci (Lond). 1993 Jul;85(1):1-4.

Ationu A, Burch M, Singer D, Littleton P, Carter N. Cardiac transplantation affects ventricular expression of brain natriuretic peptide. Cardiovasc Res. 1993 Feb;27(2):188-91.

Ationu A, Singer DRJ, Smith A, Elliott M, Burch M, Carter ND. Studies of cardiopulmonary bypass in children: implications for the regulation of brain natriuretic peptide. Cardiovasc Res. 1993 Aug;27(8):1538-41.

Sagnella GA, Markandu ND, Buckley MG, Singer DRJ, MacGregor GA. Atrial natriuretic peptide-cyclic GMP relationships in normal humans: effects of dietary sodium intake. Clin Sci (Lond). 1993 Jul;85(1):13-7.

Sagnella GA, Markandu ND, Buckley MG, Singer DRJ, MacGregor GA. Relationships between circulating ANP, cyclic GMP and sodium excretion in normal human subjects. J Hum Hypertens. 1993 Apr;7(2):181-2.

Buckley MG, Sethi D, Markandu ND, Sagnella GA, Singer DRJ, MacGregor GA. Plasma concentrations and comparisons of brain natriuretic peptide and atrial natriuretic peptide in normal subjects, cardiac transplant recipients and patients with dialysis-independent or dialysis-dependent chronic renal failure. Clin Sci (Lond). 1992 Oct;83(4):437-44.

Sagnella GA, Singer DRJ, Markandu ND, Buckley MG, MacGregor GA. Is atrial natriuretic peptide-guanosine 3',5' cyclic monophosphate coupling a determinant of urinary sodium excretion in essential hypertension? J Hypertens. 1992 Apr;10(4):349-54.

Singer DRJ, Markandu ND, Buckley MG, Miller MA, Sagnella GA, MacGregor GA. Dietary sodium and inhibition of neutral endopeptidase 24.11 in essential hypertension. Hypertension. 1991 Dec;18(6):798-804.

Sagnella GA, Markandu ND, Buckley MG, Miller MA, Singer DRJ, Cappuccio FP, MacGregor GA. Atrial natriuretic peptides in essential hypertension: basal plasma levels and relationship to sodium balance. Can J Physiol Pharmacol. 1991 Oct;69(10):1592-600.

Singer DRJ, Shirley DG, Markandu ND, Miller MA, Buckley MG, Sugden AL, Sagnella GA, MacGregor GA. How important are suppression of aldosterone and stimulation of atrial natriuretic peptide secretion in the natriuretic response to an acute sodium load in man? Clin Sci (Lond). 1991 Apr;80(4):293-9.

Cappuccio FP, Markandu ND, Sagnella GA, Singer DRJ, Buckley MG, Miller MA, MacGregor GA. Effects of amlodipine on urinary sodium excretion, renin-angiotensin-aldosterone system, atrial natriuretic peptide and blood pressure in essential hypertension. J Hum Hypertens. 1991 Apr;5(2):115-9.

Buckley MG, Sagnella GA, Markandu ND, Singer DRJ, MacGregor GA. N-terminal pro atrial natriuretic peptide in human plasma. Am J Hypertens. 1990 Dec;3(12 Pt 1):933-5.

Sagnella GA, Markandu ND, Buckley MG, Miller MA, Singer DRJ, MacGregor GA. Plasma atrial natriuretic peptide, aldosterone, and plasma renin activity responses to gradual changes in dietary sodium intake. Am J Hypertens. 1990 Nov;3(11):863-5.

Buckley MG, Sagnella GA, Markandu ND, Singer DRJ, MacGregor GA. Concentrations of N-terminal ProANP in human plasma: evidence for ProANP (1-98) as the circulating form. Clin Chim Acta. 1990 Oct 31;191(1-2):1-14.

Sagnella GA, Singer DRJ, Markandu ND, MacGregor GA, Shirley DG, Tremblay J, Hamet P. Atrial natriuretic peptide--cyclic GMP coupling and urinary sodium excretion during acute volume expansion in man. Can J Physiol Pharmacol. 1990 Apr;68(4):535-8.

Singer DRJ, Banner NR, Cox A, Patel N, Burdon M, Buckley MG, MacGregor GA, Yacoub MH. Response to dynamic exercise in cardiac transplant recipients: implications for control of the sodium regulatory hormone atrial natriuretic peptide. Clin Sci (Lond). 1990 Feb;78(2):159-63.

Buckley MG, Sagnella GA, Markandu ND, Singer DRJ, MacGregor GA. Immunoreactive N-terminal pro-atrial natriuretic peptide in human plasma: plasma levels and comparisons with alpha-human atrial natriuretic peptide in normal subjects, patients with essential hypertension, cardiac transplant and chronic renal failure. Clin Sci (Lond). 1989 Nov;77(5):573-9.

Singer DRJ, Markandu ND, Buckley MG, Miller MA, Sugden AL, Sagnella GA, MacGregor GA. Prolonged decrease in blood pressure after atrial natriuretic peptide infusion in essential hypertension: a new anti-pressor mechanism? Clin Sci (Lond). 1989 Sep;77(3):253-8.

Sagnella GA, Markandu ND, Buckley MG, Miller MA, Singer DRJ, MacGregor GA. Hormonal responses to gradual changes in dietary sodium intake in humans. Am J Physiol. 1989 Jun;256(6 Pt 2):R1171-5.

Shore AC, Markandu ND, Sagnella GA, Singer DRJ, Forsling ML, Buckley MG, Sugden AL, MacGregor GA. Endocrine and renal response to water loading and water restriction in normal man. Clin Sci (Lond). 1988 Aug;75(2):171-7.

Sagnella GA, Markandu ND, Buckley MG, Shore AC, Sugden AL, Singer DRJ, MacGregor GA. Plasma atrial natriuretic peptide in essential hypertension. Comparison with normotensive subjects and effects of changes in dietary sodium intake. Am J Hypertens. 1988 Apr;1(2):112-8.

Singer DRJ, Sagnella GA, Markandu ND, Buckley MG, MacGregor GA. Atrial natriuretic peptide, blood pressure, and age. Lancet. 1987 Dec 12;2(8572):1394-5.

Singer DRJ, Shore AC, Markandu ND, Buckley MG, Sagnella GA, MacGregor GA. Dissociation between plasma atrial natriuretic peptide levels and urinary sodium excretion after intravenous saline infusion in normal man. Clin Sci (Lond). 1987 Sep;73(3):285-9.

Sagnella GA, Markandu ND, Buckley MG, Singer DRJ, Sugden AL, Shore AC, MacGregor GA. Plasma atrial natriuretic peptide in essential hypertension: effects of changes in dietary sodium. Br Med J (Clin Res Ed). 1987 Aug 15;295(6595):417-8.

Singer DRJ, Dean JW, Buckley MG, Sagnella GA, MacGregor GA. Secretion of atrial natriuretic peptide from the heart in man. Br Heart J. 1987 Jul;58(1):24-8.

Singer DRJ. Atrial natriuretic peptides: clues to their physiological and clinical importance. Postgrad Med J. 1987 Jan;63(735):1-4.

Singer DRJ, Buckley MG, Macgregor GA, Khaghani A, Banner NR, Yacoub MH. Raised concentrations of plasma atrial natriuretic peptides in cardiac transplant recipients. Br Med J (Clin Res Ed). 1986 Nov 29;293(6559):1391-2.