Publications
Professor Donald RJ Singer
RESEARCH PRESENTATIONS
Presentations at National and International Conferences including meetings of the: American Society for Hypertension (New York and San Francisco), American Society for Nephrology (Washington), American Heart Association Council for High Blood Pressure Research (Chicago), American Heart Association Scientific Sessions (New Orleans, Dallas, Atlanta, Anaheim, Chicago), AHA Meeting on Vascular and Myocardial Aspects of Ischaemic Disease (Lake Tahoe, Nevada), British Geriatric Society, British Hypertension Society, British Pharmacology Society, British Cardiac Society, Congresses of the European Association of Clinical Pharmacology and Therapeutics (Florence, Budapest), European Federation of Internal Medicine (Florence, Brussels, Edinburgh, Berlin), European Society of Cardiology (Berlin, Stockholm, Barcelona, Vienna, Stockholm, Paris), European Cardiovascular and Cardiac Research Society (Holland), European Dialysis and Transplant Association (Brussels), European Microcirculation Society (Cambridge, Exeter), European Society for Clinical Pharmacology (Florence), European Society for Hypertension (Milan), Finnish Medical Association (Helsinki), French Hypertension Society (Paris), Gordon Conference - Angiotensin II (Aussois, Ventura), Hellenic Hypertension Society (Athens), International Conference on Salt (Kyoto), International Society for Hypertension (Heidelberg, Kyoto, Montreal, Melbourne, Madrid, Glasgow, Amsterdam), International Society for Pharmacovigilance (Rheims), International Society for Transplantation (Barcelona), International Union of Physiology Societies (Copenhagen), London Hypertension Society, Medical Research Society, Microcirculation Society (Durham, New Hampshire), National Cardiology Association of Thailand, Physiology Society, World Pharmacology Congress (Copenhagen, Montreal).
PUBLICATIONS
Blood pressure, the kidney and natriuretic peptides
1. MacGregor, GA, Sagnella, GA, Markandu, ND, Shore, AC, Buckley, MG, Cappuccio, FP & Singer, DRJ. Raised plasma levels of atrial natriuretic peptide in subjects with untreated essential hypertension. J Hypertension 1986;4(suppl 6):S567-569.
2. Sagnella, GA, Markandu, ND, Buckley, MG, Singer, DRJ, Sugden, AL, Shore, AC & MacGregor, GA. Plasma atrial natriuretic peptide in essential hypertension: effect of changes in dietary sodium. Br Med J 1987;295:417-418.
3. Singer, DRJ, Shore, AC, Markandu, ND, Buckley, MG, Sagnella, GA & MacGregor, GA. Dissociation between plasma atrial natriuretic peptide levels and urinary sodium excretion after intravenous saline infusion in normal man. Clin. Sci. 1987;73:285-289.
4. Singer, DRJ. Atrial natriuretic peptides: clues to their physiological and clinical importance. (Editorial) Postgrad Med J 1987;293:1391-1392.
5. Shore, AC, Markandu, ND, Sagnella, GA, Singer, DRJ, Forsling, ML, Buckley, MG, Sugden, AL & MacGregor, GA. The endocrine and renal response to water loading and water restriction in normal man. Clin Sci 1988;75:171-177.
6. Sagnella, GA, Markandu, ND, Buckley, MG, Shore, AC, Sugden, AL, Singer, DRJ & MacGregor, GA. Plasma atrial natriuretic peptides in essential hypertension - comparison with normal subjects and effects of changes in dietary sodium intake. Am J Hypertension 1988;1:112-118.
7. Hla-Yee-Yee, Shirley, DG, Singer, DRJ, Markandu, ND, Jones, BE & MacGregor, GA. Renal lithium clearance in essential hypertension J Hypertension 1989;7:955-960.
8. Sagnella, GA, Markandu, ND, Buckley, MG, Miller, MA, Singer, DRJ & MacGregor, GA. Hormonal responses to gradual changes in dietary sodium intake in man. Am J Physiol 1989;256:R1171-R1175.
9. Sagnella, GA, Singer, DRJ, Markandu, ND, MacGregor, GA, Shirley, DG, Tremblay, J & Hamet, P. Atrial natriuretic peptide, cyclic GMP coupling and urinary sodium excretion during acute volume expansion in man. Can J Phys Pharm 1990;68:535.
10. Sagnella, GA, Markandu, ND, Buckley, MG, Miller, MA, Singer, DRJ, & MacGregor, GA. Plasma atrial natriuretic peptide, aldosterone and plasma renin activity responses to gradual changes in dietary sodium intake. Am J Hypertension 1990;3:863-865.
11. Buckley, MG, Sagnella, GA, Markandu, ND, Singer, DRJ & MacGregor, GA. N-terminal pro-atrial natriuretic peptide in human plasma. Am J Hypertension 1990;3:933-935.
12. Buckley MG, Sagnella GA, Markandu ND, Singer DRJ, MacGregor GA. Concentrations of N-terminal ProANP in human plasma: evidence of ProANP (1-98) as the circulating form. Clinica Chimica Acta 1990; 191: 1-14.
13. Sagnella, GA, Markandu, ND, Singer, DRJ and MacGregor, GA. Kinetics of renal sodium excretion during changes in dietary sodium intake in man - an exponential process? Clinical & Experimental Hypertension - Theory and Practice 1990;12:171-178
14. Singer, DRJ, Shirley, DG, Markandu, ND, Miller, MA, Buckley, MG, Sugden, AL, Sagnella, GA, MacGregor, GA. How important are suppression of aldosterone and stimulation of atrial natriuretic peptide secretion in the natriuretic response to an acute sodium load in man? Clinical Science 1991; 80: 293-299.
15. Sagnella, GA, Singer, DRJ, Markandu, ND, Buckley, MG, MacGregor, GA. Atrial natriuretic peptide-cyclic GMP relationships in normal humans: effects of dietary sodium intake. Clin Sci 1993;85:13 - 17.
16. Sagnella, GA, Markandu, ND, Buckley, MG, Singer, DRJ, MacGregor, GA. Relationships between circulating ANP, cyclic GMP and sodium excretion in normal human subjects. J. Human Hypertension 1993;7:181-2.
17. Singer, DRJ, Markandu, ND, Morton, JJ, Miller, J.A., Sagnella, GA & MacGregor, GA. Angiotensin II is a major factor permitting excretion of an acute sodium load in man. Am J Physiol 1994;266:F89-F93.
18. Wolfensberger, TJ, Singer, DRJ, Freegard, T, Markandu, ND, Buckley, MG, MacGregor, GA. Evidence for a new role of natriuretic peptides: control of intraocular pressure. Br J Ophthalmol 1994;78:446-448.
19. Singer, DRJ, Markandu, ND, Buckley, MG, Miller, MA, Sagnella, GA. Contrasting endocrine responses to acute oral compared with intravenous sodium loading in normal man. American Journal of Physiology 1998;274:F111-119.
20. Sagnella GA, Markandu ND, Buckley MG, Miller MA, Singer DRJ, Cappuccio FP, MacGregor GA. Atrial natriuretic peptides in essential hypertension: basal plasma levels and relationship to sodium balance. Can.J. Physiol. Pharmacol. 1991;69:1592-1600.
21. Sagnella, GA, Singer, DRJ, Markandu, ND, Buckley, MG, MacGregor, GA. Is atrial natriuretic peptide-guanosine 3',5' cyclic monophosphate coupling a determinant of urinary sodium excretion in essential hypertension? J Hypertension 1992;10:349-354.
22. Bath, PMW, Cappuccio, FP, Singer, DRJ, Markandu, ND, MacGregor, GA. A high salt intake causes an increase in platelet size: a further risk factor for vascular disease? NMCD 1995;5:71-74.
23. Sagnella, GA, Markandu, ND, Onipinla, AK, Chelliah, R, Singer, DRJ, MacGregor, GA. Plasma and urinary nitrate in essential hypertension. Journal of Human Hypertension 1997; 11:587-588.
Therapeutics and blood pressure
24. Cappuccio, FP, Markandu, ND, Singer, DRJ, Beynon, G, Smith, S & MacGregor, GA. Does oral calcium supplementation lower blood pressure? A double blind study. J Hypertension 1987;5:67-71.
25. MacGregor, GA, Markandu, ND, Singer, DRJ, Cappuccio, FP, Shore, AC & Sagnella, GA. Moderate sodium restriction with converting enzyme inhibitor in essential hypertension. British Medical Journal 1987;294:531-534.
26. Singer, DRJ, Markandu, ND, Shore, AC & MacGregor, GA. Captopril and nifedipine in combination for moderate to severe essential hypertension. Hypertension 1987;9:629-633.
27. Singer, DRJ, Markandu, ND, Shore, AC & MacGregor, GA. Nifedipine and acebutolol in combination for moderate to severe essential hypertension. J Human Hypertension 1987;1:31-37.
28. MacGregor GA, Markandu ND, Singer DRJ. Diuretics and calcium antagonists in hypertension. British Journal of Clinical Practice - Symposium Supplement 1988;60:58-9
29. MacGregor, GA, Markandu, ND, Sagnella, GA, Singer, DRJ & Cappuccio, FP. Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension. Lancet 1989;ii:1244-1247.
30. Singer, DRJ, Markandu, ND, Furnival, L, Khoshnodi, L & MacGregor, GA. Moderate sodium restriction, converting enzyme inhibition and thiazide diuretic in the management of essential hypertension. J Cardiovasc Pharmacol 1989;13:(Suppl 3):S5-.
31. Singer, DRJ, Markandu, ND, Miller, MA, Sugden, AL & MacGregor, GA. Potassium channel stimulation in normal subjects and in patients with essential hypertension: an acute study with cromakalim ( BRL 34915). J Hypertension 1989;7 (suppl 6):S294-295.
32. Singer, DRJ, Markandu, ND, Sagnella, GA & MacGregor, GA. Prolonged decrease in blood pressure after atrial natriuretic peptide infusion in essential hypertension: a new anti-pressor mechanism? Clin Sci 1989;77:253-258
33. Singer, DRJ, Markandu, ND, Sugden, AL & MacGregor, GA. A comparison of the acute effects of cicletanine and bendrofluazide on urinary electrolytes and plasma potassium in essential hypertension. Eur J Clin Pharmacol 1990;39:227-232.
34. Singer, DRJ, Controlling hypertension: how far have we progressed? (Editorial). Br J Hosp Med 1990;44:159.
35. Singer, DRJ, Markandu, ND, Sugden, AL. Miller, MA & MacGregor, GA. Sodium restriction in hypertensive patients treated with a converting enzyme inhibitor and a thiazide. Hypertension 1991;17:798-803.
36. Singer, DRJ, Markandu, ND, Buckley, MG, Miller, MA, Sagnella, GA, MacGregor, GA. Dietary sodium and inhibition of neutral endopeptidase 24.11 in essential hypertension. Hypertension 1991;18:798-804.
37. Cappuccio FP, Markandu ND, Singer DRJ, Buckley MG, Miller MA, Sagnella GA, MacGregor GA. A double-blind crossover study of the effect of concomitant diuretic therapy in hypertensive patients treated with amlodipine. Am. J. Hypertension 1991; 4: 297-302.
38. Cappuccio FP, Markandu ND, Sagnella GA, Singer DRJ, Buckley MG, Miller MA, MacGregor GA. Effects of amlodipine on urinary sodium excretion, renin-angiotensin-aldosterone system, atrial natriuretic peptide and blood pressure in essential hypertension. J. Human Hypertension 1991; 5: 115-119.
39. Cappuccio FP, Markandu ND, Sagnella GA, Singer DRJ, Miller MA, Buckley MG, MacGregor GA. Acute and sustained changes in sodium balance during nifedipine treatment in essential hypertension. Am. J. Med. 1991;91:233-238.
40. Sagnella, GA, Markandu, ND, Singer, DRJ, Buckley, MG, Miller, MA & MacGregor, GA. Humoral effects of perindopril in essential hypertension. Eur J Clin Pharmacol 1991;41:625-626.
41. Singer, DRJ, Markandu, ND, Cappuccio, FP & MacGregor, GA. Studies of captopril alone and in combination with the benzothiazepine diltiazem or the dihydropyridine nifedipine in essential hypertension. J Cardiovasc Pharmacol 1991;18(Suppl 9):S51-S54.
42. Cappuccio, FP, Markandu, ND, Singer, DRJ, Crane, M, Carney, C, MacGregor, GA. Double-blind comparison between nifedipine and amlodipine for the treatment of essential hypertension. J Human Hypertension 1992; 7:365-368.
43. Cappuccio, FP, Markandu, ND, Singer, DRJ, MacGregor, GA. Amlodipine and lisinopril in combination for the treatment of essential hypertension: efficacy and predictors of response. J Hypertension 1993;11:839-847.
44. Missouris, CG, Cappuccio, FP , Markandu, ND, Singer, DRJ, MacGregor, GA. Double-blind crossover study of once daily nifedipine coat-core in essential hypertension. J Human Hypertension 1994;8:289-292.
45. Sagnella, GA, Markandu, ND, Buckley, MG, Miller, MA, Blackwod, A, Singer, DRJ, MacGregor, GA. Hormonal and renal responses to neutral endopeptidase inhibition in normal humans on a low and on a high sodium intake. Eur J Clin Invest 1995;25:165-170.
46. Singer, DRJ, Markandu, ND, Cappuccio, FP, Miller, MA, Sagnella, GA, MacGregor, GA. Reducing salt intake when on a converting enzyme inhibitor: as effective for hypertension as adding a thiazide. Hypertension 1995;25:1042-44.
47. Singer, DRJ, Jenkins, GH. Hypertension in heart transplant recipients. Annual of Cardiac Surgery 1996;:89-100.
48. Singer, DRJ, Jenkins, GH. Hypertension in transplant recipients. J Human Hypertension 1996;10:395-402.
49. Jenkins, GH, Singer, DRJ. Hypertension in thoracic transplant recipients. J Human Hypertension 1998;12:813-823.
50. Singer. DRJ. Hypertension in heart transplantation. Current Opinion in Organ Transplantation 1999;4:234-240.
51. Singer, DRJ. Managing high blood pressure: new challenges for the GP. NHS Doctor and Commissioning GP. 1999:
52. Singer, DRJ, Antonios, TFT. Hypertension: how low should our target pressure be? Insight from the UKPDS and HOT trials. European Journal of Internal Medicine 1999;10:3-5.
Circulation
53. Jones, CJH, Singer, DRJ, Watkins, N, MacGregor, GA & Caro, CG. Abnormal arterial flow pattern in untreated essential hypertension: possible link with the development of atherosclerosis. Clin Sci 1990;78:431-435.
54. McKinnon, W, Poston, L, Singer, DRJ, MacGregor, GA. Resistance artery morphology in essential hypertension and in normal subjects. J Human Hypertension 1994;8:623-62.
55. Singer, DRJ, Missouris, CG, Jeffery, S. Angiotensin converting enzyme polymorphism: what to do about all the confusion? Circulation 1996:94;236-239.
56. Missouris, CG , Barley, J, Jeffery, S, Singer, DRJ, Carter, ND, GA, MacGregor. Genetic risk for renal artery stenosis: association with deletion polymorphism in angiotensin 1-converting enzyme gene. Kidney International 1996;49:534-537.
57. Singer, DRJ, Sagnella, GA, Markandu, ND, Missouris, CG, McKinnon, WR, Knock, GA, Poston, L, MacGregor, GA. Glucose Metabolism and Resistance Arteries In Essential Hypertension. Nutrition Metabolism & Cardiovascular Diseases. 1997;7:326-330.
58. Singer, DRJ, Missouris, CG. Management of angina pectoris in primary care. Journal of the Association of Primary Care Groups. 1999:
59. Singer, DRJ. Lipids and anti-oxidants: new hopes for prevention of coronary heart disease. European Journal of Internal Medicine 1999;10:188-190.
60. Antonios, TFT, Rattray, FE, Singer, DRJ, Markandu, ND, Mortimer, PS, MacGregor, GA. Maximisation of skin capillaries during intra-vital video-microscopy: comparison between venous congestion, reactive hyperaemia and core heat load tests. Clinical Science 1999;97:523-8
61. Antonios TFT, Singer DRJ, Markandu ND, Mortimer PS, MacGregor GA. Structural skin capillary rarefaction in essential hypertension. Hypertension 1999;33:998-1001.
62. Antonios, TFT, Singer, DRJ, Mortimer, P, MacGregor, GA. Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality. Hypertension. 1999;34:655-8.
63. Buckley MG, Jenkins GH, Mitchell AG, Yacoub MH, Singer DRJ. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci. 2000;99:467-72.
64. Antonios, TF, Kaski, JC, Hasan, K, Brown, SJ, Singer, DRJ. Rarefaction of skin capillaries in patients with anginal chest pain and normal coronary angiograms. Eur Heart J 2001; 22:1144-8.
65. WE Harrison , AJ Mellor, J Clark, DRJ Singer Vasodilator pre-treatment of human radial arteries: comparison of effects of phenoxybenzamine vs. papaverine on norepinephrine-induced contraction in vitro. Eur Heart J 2001;22: 2209-2216.
66. Missouris, CG, Kalaitzidis, RG, Parchure, N, Ziakka, S, Ward, D, Singer, DRJ. Coronary heart disease in the statin and aspirin era: are results of clinical trials being put into practice? Eur J Int Med 2001;12:490-495.
67. Singer, DRJ, Singh, N. Left ventricular mass, arterial compliance and high risk of coronary heart disease in South Asians. International Journal of Cardiology 2002;(in press)
68. Singer, DRJ, Hasan, K. Central retinal vein occlusion: thrombophilia and other risk factors. Eur J Int Med 2002;(in press).
69. Singh N, Prasad S, Singer DR, MacAllister RJ. Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. Clin Sci. 2002;102:595-600.
70. Singh N, Graves J, Taylor P, MacAllister RJ, Singer D. Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects. Cardiovasc Res. 2002;56:118-25.
71. Antonios TF, Rattray FM, Singer DR, Markandu ND, Mortimer PS, MacGregor GA. Rarefaction of skin capillaries in normotensive offspring of individuals with essential hypertension. Heart. 2003;89:175-8.
72. Hussain MB, Singhal S, Markus HS, Singer DR. Abnormal vasoconstrictor responses to angiotensin II and noradrenaline in isolated small arteries from patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Stroke. 2004;35:853-8.
73. Kelsall CJ, Chester AH, Amrani M, Singer DRJ. C-type natriuretic peptide relaxes human coronary artery bypass grafts preconstricted by endothelin-1. Ann Thorac Surg. 2005;80:1347-51.
Ventricular hypertrophy, cardiac failure and transplantation
74. Singer, DRJ, Buckley, MG, MacGregor, GA, Khagani, A, Banner, NR and Yacoub, MH. Raised plasma atrial natriuretic peptides in cardiac transplant recipients. Br Med J 1986;293:1391-2.
75. Singer, DRJ, Dean , JW, Buckley, MG & MacGregor, GA. Secretion of atrial natriuretic peptides from the heart in man. Br Heart J 1987;58:24-28.
76. Buckley, MG, Sagnella, GA, Markandu, ND, Singer, DRJ and MacGregor, GA. Immunoreactive N-terminal pro-atrial natriuretic peptide in human plasma: plasma levels and comparisons with alpha-human atrial natriuretic peptide in normal subjects, patients with essential hypertension, cardiac transplant and chronic renal failure. Clin Sci 1989;77:573-579.
77. Singer, DRJ, Banner, NR, Cox, A, Patel, N, Burdon, M, Buckley, MG, MacGregor, GA & Yacoub, MH. Response to dynamic exercise in cardiac transplant recipients: implications for control of the sodium regulatory hormone atrial natriuretic peptide. Clin Sci 1990;78:159-163.
78. Buckley, MG, Sethi, D, Markandu, ND, Sagnella, GA, Singer DRJ, MacGregor, GA. Plasma concentrations and comparisons of brain natriuretic peptide and atrial natriuretic peptide in normal subjects, cardiac transplant recipients and patients with chronic renal failure. Clin Sci 1992;83:437-444.
79. Ationu, A, Singer, DRJ, Burch, M, Middleton, P, Carter, ND. Cardiac transplantation affects ventricular expression of brain natriuretic peptide. Cardiovascular Research 1993; 27:188-191.
80. Ationu, A, Sorensen, K, Whitehead, B, Singer, DRJ, Carter, ND.Ventricular expression of immunoreactive dynorphin in heart transplant recipients. Clinical Science 1993;85:1-4.
81. Singer, DRJ, Ationu A, Hassall, CJS, Mascaro, G, Treasure, T, Murday, A, Burnstock, G, Carter, ND. Secretion of insulin-like growth factor-1 from human heart. J Human Hypertension 1993:7:407-409.
82. Ationu, A, Singer, DRJ, Burch, M, Carter, ND. Studies of cardiopulmonary bypass: implications for the regulation of brain natriuretic peptide. Cardiovascular Research 1993; 27:1538-
83. Ationu, A, Sorensen, K, Whitehead, B, Singer, D, Burch, M, Carter, ND. Ventricular expression of brain natriuretic peptide following orthotopic transplantation in children - a three year follow up. Cardiovascular Research 1993;27:2135-2139.
84. Singer, DRJ, Markandu, ND, Buckley, MG, Miller, MA, Sagnella, GA, Lachno, DR, Cappuccio, FP, Murday, A, Yacoub, MH, MacGregor, GA. Blood pressure and endocrine responses to changes in dietary sodium intake in cardiac transplant recipients: implications for the control of sodium balance. Circulation 1994;89:1153-1159.
85. Ationu, A, Hassall, C, Moules, E, Patton, M, Singer, DRJ,Burnstock, G, Carter, ND. Secretion of atrial and brain natriuretic peptides from human cardiac atrial explants in culture: effect of dynorphin. Cardioscience 1994;5:81-85.
86. Ationu, A, Burch, M, Singer, D, de Leval, M, Whitehead, B, Carter, N. Ventricular expression and circulating levels of insulin-like growth factor 1 in heart transplant recipients. Clinical Science 1995;89:53-57.
87. Missouris, CG, Forbat, SM, Singer, DRJ, Markandu, ND, Underwood, R, MacGregor, GA. Echocardiography overestimates left ventricular mass: a comparative study with magnetic resonance imaging in patients with hypertension. J Hypertension 1996;14:1005-1010.
88. G H Jenkins, L A Grieve, M H Yacoub, D R J Singer Effect of Simvastatin on Ejection Fraction in Cardiac Transplant Recipients. Am J Cardiology 1996;78:1453-1456.
89. Jenkins GH, Parry DS, Foulsham L, Yacoub MH, Singer DRJ. Is cardiac reinnervation in heart transplant recipients functionally significant? Insight from studies of diurnal blood pressure variability and cardiac mass. Transplantation Proceedings 1997;29:571.
90. Buckley, MG, Marcus, N, Yacoub, MY, Singer, DRJ. Prolonged stability of the cardiac peptide BNP: importance for non-invasive assessment of cardiac function in clinical practice. Clinical Science 1998;95:235-239.
91. Missouris, CG, Grouzmann, E, Buckley, MG, Barron, J, MacGregor, GA, Singer, DRJ. How does treatment influence endocrine mechanisms in acute severe heart failure? Effects on cardiac natriuretic peptides, the renin system, neuropeptide Y and catecholamines. Clinical Science 1998;94:591-599.
92. Buckley, MG, Yacoub, MH, Singer, DRJ. Investigation of the plasma concentrations and circulating forms of BNP & ANP in orthotopic cardiac transplant recipients. J Human Hypertension 1998;12:825-6.
93. Missouris, CG, Singer, DRJ. Left ventricular hypertrophy. Hellenic Medical Journal 1999;
94. Levy T, Jenkins GH, Walker S, Grieve L, Webb C, Buckley MG, Singer DR, Paul V. Does the mechanism of action of biatrial pacing for atrial fibrillation involve changes in cardiac haemodynamics? Assessment by Doppler echocardiography and natriuretic peptide measurements. Europace. 2000;2:127-35.
95. Missouris, CG, Swift, PA, Singer DRJ. Cocaine use and acute left ventricular dysfunction. Lancet 2001;357:1586.
96. VF Puddy, VF, Amirmansour C, Williams AF, Singer DRJ. Plasma brain natriuretic peptide as a predictor of haemodynamically significant patent ductus arteriosus in preterm infants Clinical Science 2002; 103:75-7.
Renal pathophysiology
97. Singer, DRJ, Miller, JDB, Smith G. Lymphangioma of kidney. Scottish Med J 1983;28:293-294.
98. Singer, DRJ, Jenkins, AP, Gupta, S & Evans, DJ. Minimal change nephropathy in a patient with the acquired immunodeficiency syndrome. Br Med J 1985;291:868.
99. Singer, DRJ. Interpretation of tests of renal function. Maternal and Child Health. 1985;10:47-54.
100. Singer, DRJ, Venning, MC, Lockwood, CM & Pusey, CD. Cryoglobulinaemia: clinical features and response to treatment. Ann Med Int (Paris) 1986:137:251-253.
101. Singer, DRJ & Evans, DJ. Isolated granulomatous nephritis and sarcoidosis. Clin Nephrol 1986:26:250-256.
102. Singer, DRJ, Roberts, B & Cohen, J. Infective complications of plasma exchange. A prospective study. Arthritis & Rheumatism 1987;30:443-447.
103. Singer, DRJ, Simpson, JG, Catto, GD & Johnston, AW. Drug-associated granulomatous interstitial nephritis. Am J Kidney Diseases 1988;11:357-359.
104. Hla-Yee-Yee, Shirley, DG, Singer, DRJ, Markandu, ND, Buckley, MG, Sugden, AL, Miller, MA, Jones, BE & MacGregor, GA. Lack of effect of dietary potassium on renal lithium clearance in man. Scand J Clin Lab Invest 1990;50:379-384.
105. Shirley, DG, Singer, DRJ, Sagnella, GA, Buckley, MG, Miller, MA, Markandu, ND & MacGregor, GA. The effect of a single test dose of lithium carbonate on sodium and potassium excretion in man. Clin Sci 1991;81:59-63.
106. Frankel, A, Singer, DRJ, Winearls, CG, Evans, DJ, Rees, AJ & Pusey, CD. Type II essential mixed cryoglobulinaemia presentations, treatment and outcome in 13 patients. Quart. J Med. 1992;82:101-124.
107. Saggar-Malik, AK, Missouris, CG, Gill, JS, Singer, DRJ, Markandu, ND, MacGregor, GA. Increased left ventricular mass in subjects with autosomal dominant polycystic kidney disease. Br Med J 1994;309:1617-1618.
108. Folkerd, E, Singer, DRJ, Cappuccio, FP, Markandu, ND, Sampson, B, MacGregor, GA. Clearance of endogenous lithium in man: effects of dietary salt and comparison with exogenous lithium clearance. Am J Physiol 1995;268:F718-F722.
Other editorials & reviews
109. Blickle, JF & Singer, DRJ. History and aims of AEMIE, the European Association of Internal Medicine. Eur J Int Med 1989;1:5-8.
110. Singer, DRJ. Single European Act: potential effects on European health care after 1992. Eur J Int Med 1990;1:206-209.
111. Singer, DRJ. European Health Agora. Hospital Update 1992;18:83-84.
112. Munasinghe, TJK, Singer DRJ. Costs and prevention of adverse drug reactions. Eur J Int Med 2001; 12:403-405.
113. Triay J, Singer DRJ. Medical student exchange between St. George's Hospital in London and l'Hopital Saint-Louis in Paris. Eur. J. Intern. Med.. 2001;12:529-531.
114. Singer, DRJ, Kite, A. Management of hypertension in peripheral arterial disease: does the choice of drugs matter? European Journal of Vascular and Endovascular Surgery. 2008;35;701-708. doi:10.1016/j.ejvs.2008.01.007
115. Donald RJ Singer. Nine decades for the Fellowship of Postgraduate Medicine. Postgraduate Medical Journal. 2008;84:2. doi:10.1136/pgmj.2007.067017
116. Donald RJ Singer. Personalised Medicines. Pharmacology Matters special issue: Celebrating Charles Darwin. 2009;2(3):13. ISSN No: 1757-8175
117. Donald R J Singer, Michael Hulse. International Hippocrates prize for poetry and medicine. Postgrad Medical Journal. 2010;86:66-67. doi:10.1136/pgmj.2010.097527
118. DRJ Singer and M Hulse. The art of medicine. Poetry, medicine, and the International Hippocrates Prize. The Lancet 2010;375:976-977.
119. Singer, DRJ, Hulse, MW. Hippocrates Prize Awards. Postgrad Medical Journal.2010;86:(in press).
120. Hulse, MH, Singer, DRJ. Poetry and medicine. Lapidus Journal. 2010:(November:in press).
121. Singer, DRJ. Finding a niche with personalized generics: opportunities from systems-based therapeutic delivery in hypertension. Therapeutic Delivery 2010;1(5);683-691 (doi: 10.4155/tde.10.67)
122. Watkins J, Marsh A, Taylor PC, Singer, DRJ. Personalized medicine: the impact on chemistry. Therapeutic Delivery 2010;1(5);651-665 (doi: 10.4155/tde.10.64)
123. DRJ Singer. Pharmacology of the future: a clinical perspective. Pharmacology Matters special issue: Pharma Futures. 2011;4(1):9-11. ISSN No: 1757-8175
124. DRJ Singer. Research and clinical application for personalized medicine. Public Service Review. October 2011;(in press).
Books, Chapters in books, Editing of Proceedings
125. Singer, DRJ, Fallon, TJ, Schulenburg, WE, Boyd, AS, Cohen, J & Williams, G. Cytomegalovirus (CMV) retinitis in a renal transplant recipient with recurrent opportunist infection: treatment with foscarnet and CMV hyperimmune globulin. Proceedings of the European Dialysis and Transplant Association. 1985;22:645-650.
126. Singer, DRJ, Shore, AC, Markandu, ND, Sagnella, GA, MacGregor, GA. Plasma immunoreactive atrial natriuretic peptide levels during and after intravenous saline in normal man. Biologically Active Atrial Peptides, Raven Press Ltd, New York, 1988.
127. Spencer, S, Sagnella, GA, Markandu, ND, Miller, MA, Buckley, MG, Sugden, AL, Singer, DRJ & MacGregor, GA. Plasma atrial natriuretic peptide in chronic renal failure and effects of changes in dietary sodium intake. Progress in atrial peptide research. Vol III: American Society of Hypertension Symposium Series. ed BM Brenner & JH Laragh, Raven Press Ltd, New York, 1989.
128. Singer, DRJ, Markandu, ND, Cappuccio, FP & MacGregor, GA. Converting enzyme inhibition: additive effects of moderate sodium restriction in essential hypertension. In: Current Advances in ACE Inhibition 2. MacGregor GA and Sever PS, eds. Churchill Livingstone (Edinburgh London Melbourne and New York) 1991.
129. Cappuccio FP, Markandu ND, Singer DRJ, MacGRegor GA. Converting enzyme inhibitor, calcium antagonist and thiazide diuretic in combination: a rational approach to the treatment of hypertension. In: Current Advances in ACE Inhibition 2. MacGregor GA and Sever PS, eds. Churchill Livingstone (Edinburgh London Melbourne and New York) 1991.
130. Singer, DRJ & MacGregor, GA. Atrial natriuretic peptide and the pathophysiology of chronic renal disease. Chapter in "Advances in Nephrology" Ed AEG Raine Oxford University Press , 1992.
131. Singer, DRJ. Clinical relevance of atrial natriuretic peptide. In “Experimental hypertension and therapeutic progress: vasodilatation and beyond”. Festschrift for Professor S Kazda. Editors: Garthoff, B, Knorr, AM, Busse, W-D, Seuter, F, Springer Verlag, Berlin, 1995.
132. Singer, DRJ. Introduction to New themes in hypertension. re Proceedings of the Sixth Annual Symposium of the London Hypertension Society. J Human Hypertension 1995;9:634-4.
133. Singer, DRJ & Hughes, AD. Introduction to New themes in hypertension. re Proceedings of the Seventh Annual Symposium of the London Hypertension Society. J Human Hypertension 1996;10:375-6.
134. Singer, DRJ, Cappuccio, FP, Hughes, AD. New themes in hypertension: introduction. Journal of Human Hypertension 1997; 11:551-552.
135. Singer, DRJ, Yacoub, MH. Hypertension in transplant recipients: introduction. Journal of Human Hypertension 1998 (in press)
136. Singer, DRJ, Cappuccio, FP, Hughes, AD. New themes in hypertension. 9th Annual Symposium of the London Hypertension Society. Journal of Human Hypertension 1999 (in press)
137. Singer, DRJ, Cappuccio, FP, Hughes, AD. Carter, ND. New themes in hypertension. 10th Annual Symposium of the London Hypertension Society. Journal of Human Hypertension 2000;14:359.
138. Singer, DRJ, Cappuccio, FP, Hughes, AD. New themes in hypertension. 11th Annual Symposium of the London Hypertension Society. NMCD 2000;10:223.
139. Singer, DRJ, Cappuccio, FP, Hughes, AD. New horizons in hypertension. 12th Annual Symposium of the London Hypertension Society. NMCD 2001;11:.
140. Pocket Prescriber. TRJ Nicolson. Ed. DRJ Singer. 244 pages, Hodder Arnold, London 2004 ISBN 034081151X
141. Pocket Prescriber. TRJ Nicolson. Ed. DRJ Singer. 240 pages, Hodder Arnold, London October, 2006 ISBN 0340939079
142. TRJ Nicholson, A Gunarathne, DRJ Singer. Pocket Prescriber 2010. Hodder Education November, 2009.
143. TRJ Nicholson, A Gunarathne, DRJ Singer. Pocket Prescriber 2010. Mobile version - www.skyscape.com June, 2010.
144. Donald R J Singer, Michael Hulse. International Hippocrates prize for poetry and medicine. Postgrad Medical Journal. 2010;86:66-67. doi:10.1136/pgmj.2010.097527
145. DRJ Singer and M Hulse. The art of medicine. Poetry, medicine, and the International Hippocrates Prize. The Lancet 2010;375:976-977.
146. Singer, DRJ, Hulse, MW. Hippocrates Prize Awards. Postgrad Medical Journal.2010;86:(in press).
147. Hulse, MH, Singer, DRJ. Poetry and medicine. Lapidus Journal. 2010:(November:in press).
148. Singer, DRJ. Finding a niche with personalized generics: opportunities from systems-based therapeutic delivery in hypertension. Therapeutic Delivery 2010;1(5);683-691 (doi: 10.4155/tde.10.67)
149. Watkins J, Marsh A, Taylor PC, Singer, DRJ. Personalized medicine: the impact on chemistry. Therapeutic Delivery 2010;1(5);651-665 (doi: 10.4155/tde.10.64)
150. TRJ Nicholson and DRJ Singer. Pocket Prescriber 2011. Hodder Education Published: February, 2011.
Correspondence and short reports
151. Singer, DRJ. Candidiasis complicating cimetidine treatment. Lancet 1981;ii:1047.
152. Singer, DRJ & Cohen, J. Safety of plasma exchange. Lancet 1982;ii:1462.
153. Singer, DRJ, Fallon, TJ, Schulenburg,WE, Williams, G & Cohen, J. Foscarnet for cytomegalovirus retinitis. Ann Int Med 1985;103:962.
154. Singer, DRJ & Almdal, TP. Potential route of transmission of HTLV III infection. J Infection 1986;12:86-87.
155. Singer, DRJ & MacGregor, GA. Angio-neurotic oedema associated with two angiotensin converting enzyme inhibitors. Br Med J 1986;293:124.
156. Singer, DRJ, Shore, AC, Markandu, ND, Buckley, MG & MacGregor, GA. Atrial natriuretic peptide levels in treated congestive heart failure. Lancet 1986;i:851.
157. Singer, DRJ, Sagnella, GA, Markandu, ND, Buckley, MG, & MacGregor, GA. Atrial natriuretic peptide, blood pressure and age. Lancet 1987;ii:1394-1395.
158. Cappuccio, FP, Singer, DRJ & MacGregor, GA. The effects of thiazides plus calcium channel blockers. JAMA 1990;264:971-972.
159. Singer, DRJ, Cappuccio, FP & MacGregor, GA. Efficacy of nifedipine in combination treatments for angina. Lancet 1991;338:1535-1536.
160. Missouris, CG, Singer, DRJ, Hanson, P, Sever, P, MacGregor, GA. Unusual stress fracture in a cricketer. Lancet 1993;342:1152.
161. Antonios, T, Millard, J, Wilson, A, Singer, DRJ, MacGregor, GA. Unusual tracheal tumour. Postgraduate Medical Journal 1994;70:910-912.
162. Missouris, CG, Singer, DRJ, Redwood. Angina complicating radiotherapy. Lancet 1996;347:408.
163. Missouris CG, Forbat S, Singer DRJ, Underwood SR, MacGregor GA. Does echocardiography over-estimate left ventricular mass? J Hypertension 1997 12: 213-214.
164. Singer DRJ, Missouris CG, Jeffery S. ACE*D and cardiovascular disease. Circulation 1997;96:1051-2.
165. Missouris CG, Forbat S, Underwood SR, MacGregor GA, Singer DRJ. Measurement of LV mass in man J Hypertension 1998;16:257-8.
166. Singer, DRJ. The hormonal control of blood pressure following thermal injury in children. British Journal of Intensive Care 1998;8:63.
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International seminars & lectures in Australia (Perth), China (Changchun, Shanghai), Czech Republic (Prague), Finland (Helsinki), France (Nancy, Reims), Holland (Maastricht, Rotterdam), Hungary (Budapest, Pecs), Iceland (Reykjavik), Italy (Florence, Naples), Germany (Berlin), Greece (Athens), Japan (Tokyo, Osaka, Hirakata, Nagoya), Morroco (Fes), Switzerland (Lausanne), Thailand, USA (Boston, Salt Lake City, Stanford)
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