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Professor Dimitris Grammatopoulos


Dimitris Grammatopoulos

TITLE   


Professor of Molecular Medicine

Lead for Research Degrees (Translational and Systems Medicine)

CONTACT   


Metabolic & Vascular Health
University Hospital Coventry & Warwickshire
Clinical Sciences Building
Clinical Sciences Research Laboratories
Coventry
CV2 2DX
Tel: 024 7696 8661
Fax: 024 7657 4637
Email: D.Grammatopoulos@warwick.ac.uk

 


RESEARCH PROFILE


BASIC RESEARCH

CRH and its receptors as molecular transducers of the stress response in health and disease.

CRH receptors as a model to dissect GPCR signaling

Placental biology in metabolically compromised pregnancies

TRANSLATIONAL/CLINICAL RESEARCH

The HPA-stress axis and genetic risk of postnatal depression

Molecular non-invasive diagnosis of trisomy 21


RESEARCH GROUPS



BACKGROUND


MRC Visiting Fellow, Johns Hopkins, Baltimore 1996-1997

Wellcome Trust Career Development Fellow 1998-2003

Wellcome Trust University Award Senior Fellow 2003-2008

Professor of Molecular Medicine 2006-present

Fellow of the Royal College of Pathologists 2007

CURRENT RESEARCH PROJECTS


  • Identifying women at risk of postnatal depression (PND) by checking for specific genetic variants., Funded by: James Tudor Foundation, The, Project Start Date: 01/06/2014 Project End Date: 31/05/2016
  • A genetic test for pregnant women to be able to identify risk of developing post-natal depression. KTP with SWFT, with Dr Saverio Stranges MD, PhD - Health Sciences -, Funded by: Technology Strategy Board, Project Start Date: 01/02/2014 Project End Date: 31/01/2016

    View all Research Projects


SELECTED PUBLICATIONS


  • Grammatopoulos DK (2014) 'CRH-R splicing in estrogen-sensitive breat cancer. [Epub ahead of print]' Cell Cycle 13 (5), [article]
  • Yeung KY, Dickinson A, Donoghue JF, Polekhina G, Whote SJ, Grammatopoulos DK, McKenzie M, Johns TG, John JC (2014) 'The identification of mitochondrial DNA variants in glioblastoma multiforme' Acta Neuropathologica Communications 2 (1:1), [article]
  • Chen L, Lei K, Malawana J, Yulia A, Sooranna SR, Bennett PR, Liang Z, Grammatopoulos D, Johnson MR (2014) 'Cyclic AMP enhances progesterone action in human myometrial cells' Journal of Molecular Cell Biology 382 (1), 334 - 343 [article]
  • Sivakumar K, Bari MF, Adaikalakoteswari A, Guller S, Weickert MO, Randeva HS, Grammatopoulos DK, Bastie CC, Vatish M (2013) 'Elevated fetal adipsin/acylation-stimulating progein (ASP) in obese pregnance: novel placental secretion via Hofbauer cells' Journal Of Clinical Endocrinology And Metabolism 98 (10), 4113 - 4122 [article]
  • Engineer N, Darwin L, Nishigandh D, Ngianga-Bakwin K, Smith SC, Grammatopoulos DK (2013) 'Association of glucocorticoid and type 1 corticotropin-releasing hormone hormone receptors gene variants and risk for depression during pregnancy and post-partum' Journal of Psychiatric Research 47 (9), 1166 - 1173 [article]

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Conferences


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My Profile last updated: 02/06/2015

WCPRS/CWPS Funded PhD Studentship

CRH in the news

Lab news

Warwick-Monash Alliance

Joint Doctoral Programme in

Reproductive Biology and Metabolic disease

PhD positions available