RESEARCH PROFILE

Research in this group centres on Ca2+ signalling in hepatocytes. In particular, we are interested in the role of Ca2+ efflux across the plasma membrane in hepatocyte Ca2+ signalling under both physiological and pathophysiological conditions.

RESEARCH PROJECTS

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SELECTED PUBLICATIONS

• Stratton, R. C., Squires, P.E. and Green, A.K.(2010) '17 -Estradiol Elevates cGMP and, via Plasma Membrane Recruitment of Protein Kinase GI , Stimulates Ca2+ Efflux from Rat Hepatocytes' Journal Of Biological Chemistry 285 (35), 27201 - 27212 (0021-9258)
• Marhl, M., Gosak, M., Perc, M., Dixon, C. J. and Green, A. K.(2008) 'Spatio-temporal modelling explains the effect of reduced plasma membrane Ca2+ efflux on intracellular Ca2+ oscillations in hepatocytes' Journal Of Theoretical Biology 252 (3), 419 - 426 (0022-5193)
• Pahle, J., Green A. K., Dixon C. J. and Kummer, U.(2008) 'Information transfer in signaling pathways: a study using coupled simulated and experimental data' BMC Bioinformatics 9 139 (1471-2105)
• Perc, M., Green, A. K., Dixon, C. J. and Marhl, M.(2008) 'Establishing the stochastic nature of intracellular calcium oscillations from experimental data' Biophysical Chemistry 132 (1), 33 - 38 (0301-4622)
• Stratton, R. et al.(2008) 'ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIa' Biochemical And Biophysical Research Communications 368 (4), 965 - 970 (0006-291X)

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Conferences