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Further publications

Peter Winstanley



2009 Journals


  • Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., Hughes, D. A., Molyneux, M. E., Ward, S. A., Winstanley, P. A. and Lalloo, D. G. (2009) 'Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi', Malaria Journal, 8 (204), (1475-2875) [article]

2008 Journals


  • Ochong, E., Bell, D. J., Johnson, D. J., D' Alessandro, U., Mulenga, M., Muangnoicharoen, S., Van Geertruyden, J. -P., Winstanley, P. A., Bray, P. G., Ward, S. A. and Owen, A. (2008) 'Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate Drug Pressure', Antimicrobial Agents And Chemotherapy, 52 (11), 3883 - 3888 (0066-4804)
  • Bell, D. J., Nyirongo, S. K., Mukaka, M., Zijlstra, E. A., Plowe, C. V., Molyneux, M. E, Ward, S. A. and Winstanley, P. A. (2008) 'Sulfadoxine-pyrimethamine?based combinations for malaria : a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi', PLoS One, 3 (2), (1932-6203) [article]
  • Wootton, D. G., Opara, H., Biagini, G. A., Kanjala, M. K., Duparc, S., Kirby, P. L., Woessner, M., Neate, C., Nyirenda, M., Blencowe, H., Dube-Mbeye, Q., Kanyok, T., Ward, S., Molyneux, M., Dunyo, S. and Winstanley, P. A. (2008) 'Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap?) alone or with three different doses of artesunate for uncomplicated plasmodium falciparum malaria', PLoS One, 3 (3), (1932-6203) [article]

2007 Journals


  • Munir Pirmohamed, Kwame N Atuah, Alex N O Dodoo and Peter Winstanley (2007) 'Pharmacovigilance in developing countries', BMJ, 335 (0959-535X)
  • Bell DJ, Nyirongo S, Molyneux ME, Winstanley PA, Ward SA (2007) 'Practical hplc methods for the quantitative determination of common antimalarials in Africa', Journal Of Chromatography B, 847 231 - 236 (1570-0232)
  • Amin A, Walley T, Kokwaro G, Winstanley P.A, Snow R.W (2007) 'Commentary - reconciling national treatment policies and drug regulation in Kenya', Health Policy & Planning, - (0268-1080)

2006 Journals


  • Simpson JA, Hughes D, Manyando C, Bojang K, Aarons L, Winstanley PA, Edwards G, Watkins WM, Ward S (2006) 'Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone', British Journal Of Clinical Pharmacology, 61 289 - 300 (0306-5251)

2005 Journals


  • Alexis Nzila, Edwin Ochong, Eunice Nduati, Kokwaro Gilbert, Peter Winstanley, Steve Ward and Kevin Marsh (2005) 'Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet', Journal Of Infectious Diseases, 99 341 - 347 (0022-1899)

2004 Journals


  • Robert L. Clark, Tacey E.K. White, Sally Clode, Ian Gaunt, Peter Winstanley and Stephen Ward (2004) 'Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit', Journal Of Infectious Diseases, 71 80 - 94 (0022-1899)
  • Alloueche A, Bailey W, Barton S, Bwika J, Chimpeni P, Falade CO, Fehintola FA,Horton J, Jaffar S, Kanyok T, Kremsner PG, Kublin JG, Lang T, Missinou MA,Mkandala C, Oduola AM, Premji Z, Robertson L, Sowunmi A, Ward SA, Winstanley PA (2004) 'Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children - double-blind randomised controlled trial', Lancet, The, 363 1843 - 1848 (0140-6736)
  • Bates S.J, Winstanley P.A, Watkins W.M, Alloueche A, Bwika J, Happi T.C, Kremsner P.G, Kublin J.G, Premji Z, Sibley C.H (2004) 'Rare, highly pyrimethamine-resistant alleles of Plasmodium falciparum dihydrofolate reductase from five African sites', Journal Of Infectious Diseases, 190 1783 - 1792 (0022-1899)
  • Amin A, Hughes D, Marsh V, Abuya T, Kokwaro G, Winstanley P.A, Ochola S, Snow R.W (2004) 'The difference between effectiveness and efficacy of antimalarial drugs in Kenya', Tropical Medicine and International Health, 9 967 - 974 (1360-2276)

2003 Journals


  • Nzila A, Mberu E, Bray P, Kokwaro G, Winstanley P, Marsh K, Ward S (2003) 'Chemosensitization of Plasmodium falciparum by probenecid in vitro', Antimicrobial Agents And Chemotherapy, 47 2108 - 2112 (0066-4804)
  • Lochhead J, Movaffaghy A, Falsini B, Winstanley PA, Mberu EK, Riva CE, Molyneux, ME, Taylor TE, Harding SP (2003) 'The effect of quinine on the electroretinograms of children with pediatric cerebral malaria', Journal Of Infectious Diseases, 187 1342 - 1345 (0022-1899)
  • O'Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK (2003) 'Isoquine and related amodiaquine analogues - a new generation of improved 4-aminoquinoline antimalarials', Journal of Medicinal Chemistry, 46 4933 - 4945 (0022-2623)

2002 Journals


  • Kublin JG, Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, Martino LM, Mukadam RA, Rogerson SJ, Lescano AG, Molyneux ME, Winstanley PA, Chimpeni P, Taylor TE, Plowe CV (2002) 'Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria', Journal Of Infectious Diseases, 185 380 - 388 (0022-1899)
  • Sulo J, Chimpeni P, Hatcher J, Molyneux M.E, Taylor T, Marsh K, Watkins W, Winstanley PA (2002) 'Two-centre randomised trial of chlorproguanil-dapsone in uncomplicated falciparum malaria - effect of rapid elimination on frequency of treatment during 1 year follow-up', Lancet, The, 360 1136 - 1143 (0140-6736)

2001 Journals


  • Mutabingwa T, Nzila A, Mberu E, Nduati E, Winstanley P, Hills E, Watkins W (2001) 'Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania', Lancet, The, 358 1218 - 1223 (0140-6736)

2000 Journals


  • Nzila A, Nduati E, Mberu E, Sibley C, Monks S, Winstanley P.A, Watkins W.M (2000) 'Molecular evidence of greater selective pressure for drug resistance exerted by the long acting antifolate pyrimethamine/sulfadoxine compared with the shorter acting chlorproguanil-dapsone on Kenyan Plasmodium falciparum', Journal Of Infectious Diseases, 181 2023 - 2028 (0022-1899)
  • Crawley J, Waruiru C, Mithwani S, Mwangi I, Watkins W.M, Ouma D, Winstanley P.A, Peto T, Marsh K (2000) 'Effect of Phenobarbital on seizure frequency and mortality in childhood cerebral malaria', Lancet, The, 355 701 - 707 (0140-6736)
  • Nzila A, Mberu E, Sulo J, Dayo H, Winstanley P.A, Sibley C, Watkins W (2000) 'Towards an understanding of the mechanism ofpyrimethamine-sulfaxoxine resistance in Plasmodium falciparum - the genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites', Antimicrobial Agents And Chemotherapy, 44 991 - 996 (0066-4804)
  • Almond S, Szwandt S, Edwards G, Lee M, Bary M, Winstanley P.A (2000) 'The disposition of intravenous pyrimethamine in healthy normal volunteers', Antimicrobial Agents And Chemotherapy, 44 1691 - 1693 (0066-4804)
  • Maggs J, Bishop L, Edwards G, O?Neill P, Ward S, Winstanley P.A, Park B.K (2000) 'Biliary metabolites of b-artemether in rats - biotransformations of an antimalrial endoperoxide', Antimicrobial Agents And Chemotherapy, 28 209 - 217 (0066-4804)

1999 Journals


  • Kinyanjui S, Mberu E, Winstanley P.A, Jacobus D, Watkins W.M (1999) 'The antimalarial triazine WR99210 and the prodrug PS-15 - folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug', American Journal Of Tropical Medicine And Hygiene, 60 943 - 948 (0002-9637)
  • Paklah R, Lambert J, Ansko P, Winstanley P.A, Davies P, Kiivet R (1999) 'Comparative bioavailability of three different preparations of rifampicin', Journal Of Clinical Pharmacy And Therapeutics, 24 219 - 225 (0269-4727)

1998 Journals


  • Hariuki K, Winstanley P.A, Watkins W.M, Marsh K (1998) 'Quinine sensitivity of isolates of Plasmodium falciparum from the coast of Kenya', Antimicrobial Agents And Chemotherapy, 92 195 - 196 (0066-4804)
  • Nzila-Mouanda A, Mberu E.K, Sibley C.H, Plowe C.V, Winstanley P.A, Watkins W.M (1998) 'Kenyan Plasmodium falciparum field isolates - correlation between pyrimethamine and chlorcycloguanil activitiy in vitro and point mutations in the dihydrofolate reductase gene', Antimicrobial Agents And Chemotherapy, 42 164 - 169 (0066-4804)

1997 Journals


  • Winstanley P.A, Watkins W.M, Muhia d, Szwandt S, Amukoye E, Marsh K (1997) 'Chlorproguanil-dapsone for uncomplicated falciparum malaria in young children - pharmacokinetics and therapeutic range', British Journal Of Clinical Pharmacology, 91 322 - 327 (0306-5251)
  • Amukoye E, Winstanley P.A, Watkins W.M, Snow R.W, Hatcher J, Mosobo M, Ngumbao E, Lowe B, Ton M, Minyiri G, Marsh K (1997) 'Chorproguanil-dapsone - an effective treatment for uncomplicated falciparum malaria', Antimicrobial Agents And Chemotherapy, - 2261 - 2264 (0066-4804)
  • Plowe C.V, cortese J.F, Djimde A, Nwanyanwu O.C, Watkins W.M, Winstanley P.A, EstradaFranco J.G, Mollinedo R.E, Avila J.C, Cespedes J.L, Carter D, Doumbo O.K (1997) 'Mutations in Plasmodium falciparum dihdrofolate reductase and hihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulpadoxine use and resistance', Journal Of Infectious Diseases, 176 1590 - 1596 (0022-1899)
  • Pirmohamed M, Winstanley P.A (1997) 'Hepatitis B vaccine and neurotoxicity', Journal of Postgraduate Medicine, 73 462 - 463 (0022-3859)
  • Newton C.R.J.C, Chokwe T, Armstrong-Schellenberg J, Winstanley P.A, Forster D, Peshu N, Kirkham F.J, Marsh K (1997) 'Coma scales for children with severe falciparum malaria', Tropical Medicine and International Health, 91 161 - 166 (1360-2276)
  • Newton C.R.J.C, Warn P.A, Winstanley P.A, Peshu N, Snow R.W, Pasvol G, Marsh K (1997) 'Severe anaemia in children living in a malaria endemic area of Kenya', Tropical Medicine and International Health, 2 165 - 178 (1360-2276)
  • Hero M, Harding S.P, Riva C.E, Winstanley P.A, Peshu N, Marsh K (1997) 'Photographic and angiopathic characterization of the retina of Kenyan children with severe malaria', Parasitology Today, 115 997 - 1003
  • Watkins W.M, Mberu E.K, Winstanley P.A, Plowe C (1997) 'The efficacy of antifolate combinations in Africa - a predictive model based on pharmacodynamic and pharmacokinetic analyses', Parasitology Today, 13 459 - 464
  • Murphy S.A, Mberu E, Muhia D, English M, Crawley J, Waruiru C, Lowe B, Newton C, Winstanley P.A, Marsh K, Watkins W.M (1997) 'The disposition of intramuscular artemether in children with cerebral malaria - a preliminary study', Tropical Medicine and International Health, 91 331 - 334 (1360-2276)

1996 Journals


  • Kokwaro G, Edwards G, Ward S.A, Winstanley P.A, Marsh K, Watkins W.M (1996) 'Common antimalarial drugs do not affect metabolism of diazepam and desmethyldiazepam by human liver microsomes in-vitro', British Journal Of Clinical Pharmacology, 2 243 - 245 (0306-5251)
  • Waruiru C.M, Newton C.R.J.C, Forster D, New L, Winstanley P.A, Mwangi I, Marsh V, Winstanley M, Snow R.W, Marsh K (1996) 'Epileptic seizures and malaria Kenyan Children', American Journal Of Tropical Medicine And Hygiene, 90 152 - 155 (0002-9637)
  • Murphy S, English M, Waruiru C, Mwangi I, Amukoye E, Crawley J, Newton C, Winstanley P.A, Peshu N, Marsh K (1996) 'An open randomised trial of artemether versus quinine in the treatment of cerebral malaria in African children', British Journal Of Clinical Pharmacology, 90 298 - 301 (0306-5251)
  • Watkins W.M, Mungai M, Muhia D, Mberu E, Gahua S, Winstanley P.A, Gilks C, Nunn P (1996) 'Cutaneous hypersensitivity reactions to thiacetazone, HIV infection and thiacetazone concentrations in plasma', British Journal Of Clinical Pharmacology, 41 160 - 163 (0306-5251)
  • Bonington A, Davidson R, Winstanley P, Pasvol G (1996) 'Fatal quinine cardiotoxicity in the treatment of falciparum malaria', British Journal Of Clinical Pharmacology, 90 305 - 307 (0306-5251)

1995 Journals


  • Winstanley P.A, Mberu E.K, S\wandt I.S.F, Breckenridge A.M, Watkins W.M (1995) 'The in-vitro activity of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte colony-forming-units', Antimicrobial Agents And Chemotherapy, 39 948 - 952 (0066-4804)
  • Murphy S, Watkins W.M, Bray P, Lowe B, Winstanley P.A, Marsh K (1995) 'Parasite viability during the treatment of severe falciparum malaria - differential effects of artemether and quinine', American Journal Of Tropical Medicine And Hygiene, 53 303 - 305 (0002-9637)
  • Watkins W.M, Winstanley P.A, Mberu E.K, Kokwaro G, Murphy S.A, Newton C.R, Mwangi I, Forster D, Marsh K (1995) 'Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria', British Journal Of Clinical Pharmacology, 39 283 - 289 (0306-5251)
  • Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, Newton C, Winstanley P.A, Warn P, Peshu N (1995) 'Indicators of life-threatening malaria in African children', New England Journal Of Medicine, 332 1399 - 1404 (0028-4793)
  • Winstanley P.A, Khoo S, Szwandt I.S.F, Edwards G, Wilkins E, Tjia J, Coker R, McKane W, Beching N, Watkin S, Breckenridge A.M (1995) 'Marked variation in pyrimethamine disposition in aids patients treated for cerebral toxoplasmosis', Journal Of Antimicrobial Chemotherapy, 36 435 - 439 (0305-7453)

1994 Journals


  • Winstanley P.A, Mberu E, Watkins W.M, Murphy S.A, Lowe B, Marsh K (1994) 'Towards optimal parenteral quinine regimens for young children with cerebral malaria - unbound quinine concentratins following a simple loading dose regimen', Lancet, The, 88 577 - 580 (0140-6736)

1993 Journals


  • Snow R.W, Armstrong-Schellenberg J.R.M, Peshu N, Forster D, Newton C.R.J.C, Winstanley P.A, Mwangi I, Waruiru C, Warn P.A, Newbold C, Marsh K (1993) 'Periodicity and space-time clustering of severe childhood malaria on the coast of Kenya', Lancet, The, 97 386 - 390 (0140-6736)
  • Newton C.R.J.C, Winstanley P.A, Watkins W.M, Mwangi I.N, Waruiru C.M, Mberu E.K, Peshu N, Warn P.A, Marsh K (1993) 'Single dose intramuscular pyrimethamine-sufadoxine as an adjunct to quinine in the treatment of severe malaria - pharmacokinetcs and efficacy', Lancet, The, 87 207 - 210 (0140-6736)
  • Winstanley P.A, Newton C.R, Watkins W.M, Mberu E, Ward S.A, Warn P.A, Mwangi I, Waruiru C, Pasvol G, Warrell D.A, Marsh K (1993) 'Towards optimal parenteral quinine regimens for young children with cerebral malaria - importance of unbound quinine concentration', Lancet, The, 87 201 - 206 (0140-6736)

1992 Journals


  • Winstanley P.A, Newton C.R.J.C, Pasvol G, Kirkham F.J, Mberu E, Peshu N, Ward S.A, were J.B.O, Warrel D.A, Marsh K (1992) 'Prophylactic phenobarbitone in young children with severe falciparum malaria - pharmacokinetics and clinical effects', British Journal Of Clinical Pharmacology, 33 149 - 154 (0306-5251)
  • Snow R.W, Armstrong J.R.M, Forster D, Winstanley M.T, Marsh V.M, Newton C.R, Waruiru C, Mwangi I, Wnstanley P.A., Marsh K (1992) 'Childhood deaths in Africa - uses and limitations of verbal autopsies', Lancet, The, 340 351 - 355 (0140-6736)
  • Winstanley P.A, Watkins W.M, Newton C.R.J.C, Nevill C, Mberu E, Warn P.A, Waruiru C.M, Mwangi I.N, Warrell D.A, Marsh K (1992) 'The disposition of oral and intramuscular pyrimethamine-sulphoxadine in Kenyan children with high parasitaemia but clinically non-severe falciparum malaria', British Journal Of Clinical Pharmacology, 33 143 - 148 (0306-5251)

1991 Journals


  • Newton C.R.J.C, Kirkham F.K, Winstanley P.A, Pasvol G, Peshu N, Warrell D.A, Marsh K (1991) 'Intracranial pressure in African children with cerebral malaria', Lancet, The, 337 573 - 576 (0140-6736)
  • Pasvol G, Newton C.R.J.C, Winstanley P.A, Watkins W.M, Peshu N, Were J.B.O, Marsh K, Warrell D.A (1991) 'Quinine treatment of severe falciparum malaria in African children - A randomised comparison of three regimens', American Journal Of Tropical Medicine And Hygiene, 45 702 - 713 (0002-9637)
  • Mberu E.K, Ward S.A, Winstanley P.A, Watkins W.M (1991) 'Measurement of quinine in filter paper absorbed blood by high performance liquid chromatography', Journal Of Chromatography, 570 180 - 184

1990 Journals


  • Winstanley P.A, Simooya O, Kofi-Ekue J.M, Walker O, Salako L.A, Edwards G, Orme M.L?E, Breckenridge A.M (1990) 'The disposition of maodiaquine in Zambians and Nigerians with malaria', British Journal Of Clinical Pharmacology, 29 695 - 701 (0306-5251)
  • Walley T, Winstanley P.A, Roberts D, Grimmer M, Orme M.L?E, Breckenridge A.M (1990) 'Adverse effects of captopril in hospital outpatients with hypertension', Postgraduate Medical Journal, 66 106 - 109 (0032-5473)
  • Winstanley P.A, Coleman J.W, Maggs J.M, Breckenridge A.M, Park B.K (1990) 'The toxicity of amodiaquine and its principal metabolites towards mononuclear leukocytes and granulocyte-monocyte colony formingunits', British Journal Of Clinical Pharmacology, 29 479 - 485 (0306-5251)

1989 Journals


  • Winstanley P.A., Irvin L.E, Smith J.C, Orme M.L?E, Breckenridge A.M (1989) 'Adverse drug reactions - a hospital pharmacy-based reporting scheme', British Journal Of Clinical Pharmacology, 28 113 - 117 (0306-5251)

1988 Journals


  • Winstanley P.A, Edwards G, Curtis C.G, Orme M.L?E, Powell G.M, Breckenridge A.M (1988) 'Tissue distribution and excretion of amodiaquine in the rat', Journal Of Pharmacy And Pharmacology, 40 343 - 349

1987 Journals


  • Roberts D.H, Tsao Y, Grimmer S.F.M, Winstanley P.A, Orme M.L?E, Breckenridge A.M (1987) 'Haemodynamic effects of atenolol, labetalol, pindlol and captopril; a comparison in hypertensive patients with special reference to changes in limb blood flow, heart rate and left verntricular function', British Journal Of Clinical Pharmacology, 24 153 - 172 (0306-5251)
  • Winstanley P.A, Manning A.S.P, Lintott D, Axon A.T.R (1987) 'Endoscopic retrograde cholangiopancreatography in pancreatitis with persistent or recurrent pain', British Journal Of Clinical Pharmacology, 1 407 - 412 (0306-5251)
  • Winstanley P.A., Edwards G, Orme M.L?E, Breckenridge A.M (1987) 'Effect of doze size on amodiaquine pharmacokinetics after oral administration', European Journal Of Clinical Pharmacology, 33 331 - 333 (0031-6970)
  • Winstanley P.A, Edwards G, Orme M.L?E, Breckenridge A.M (1987) 'The disposition of amodiaquine in man after oral administration', British Journal Of Clinical Pharmacology, 23 1 - 7 (0306-5251)

1986 Journals


  • Winstanley PA, Manning AP, Lintott DJ, Axon AT (1986) 'Endoscopic retrograde cholangio-pancreatography in pancreatitis with persistent or recurrent pain', Lancet, The, 1 407 - 412 (0140-6736)
  • Hatton C, Peto T, Bunch C, Pasvol G, Russel S, Singer C Edwards G, Winstanley P.A (1986) 'Frequency of severe neutropaenia associated with amodiaquine prophylaxis against malaria', Lancet, The, 1 411 - 413 (0140-6736)
  • Juby L, Axon A.T.R, Wright V, Winstanley P.A, Rothwell J (1986) 'Abnormal small intestinal permeability in patients taking mefanamic acid', British Journal Of Rheumatology, 25 226 - 227 (0263-7103)

1985 Journals


  • Winstanley P.A., Tjia J, Back D.J, Hobson D, Breckenridge A.M (1985) 'Lack of effect of highly purified subunit influenza vaccine on theophylline metabolism', British Journal Of Clinical Pharmacology, 20 47 - 53 (0306-5251)
  • Winstanley P.A, Ellis W.R, Hamilton I, Lintott D, Axon A.T.R (1985) 'Medium term complications of endoscopic biliary sphincterotomy', Gut, 26 730 - 733 (0017-5749)

1984 Journals


  • Winstanley PA, Young JB, Axon AT, Brownjohn AM, Cooper EH (1984) 'Renal proximal tubular dysfunction in Crohn's disease (Letter to BMJ)', BMJ, 288 1612 - 1613 (0959-535X)
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