Tripathi

Job Title

Associate Professor

Department

WMS - Translational Medicine

Phone

024 7696 8590

G.Tripathi@warwick.ac.uk

Biography

Dr. Gyanendra Tripathi graduated with MSc in Biotechnology from Indian Institute of Technology, Mumbai, India (1993) and completed his PhD on, Regulation of genes involved in the synthesis of biodegradable biolpolymer, polyhydroxy butyrate, in 1998 from National Chemical Laboratory, India on a Council of Scientific and Industrial Research Fellowship. In 1999 he moved to University of Aberdeen, and did his first postdoctoral training on, transcriptional regulation of Gcn4 in Candida albicans. Later in 2002 he moved to Babraham Institute, Cambridge to work on mouse transgenics and IGF signalling. He was appointed as RCUK academic fellow at University of Warwick in 2005. Currently he holds the position of Associate Professor at Warwick Medical School, University of Warwick and is part of Diabetes and Metabolism research theme.

Pushpakom, S. P., Adaikalakoteswari, Antonysunil, Owen, A., Back, D. J., Tripathi, Gyanendra, Kumar, Sudhesh, McTernan, P. G., Pirmohamed, M., 2018. Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro. Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease, 15 (3), pp. 233-242
Jackisch, Laura, Kumsaiyai, W., Moore, Jonathan D., Al-Daghri, N. M., Kyrou, Ioannis, Barber, T. M., Randeva, Harpal S., Kumar, Sudhesh, Tripathi, Gyanendra, McTernan, P. G., 2018. Differential expression of Lp-PLA2 in obesity, type 2 diabetes and the influence of lipids. Diabetologia, 61, pp. 1155-1166
Martinez de la Escalera Clapp, Lucia, Kyrou, Ioannis, Vrbikova, Jana, Hainer, Voitech, Sramkova, Petra, Fried, Martin, Piya, Milan K., Kumar, Sudhesh, Tripathi, Gyanendra, McTernan, P. G., 2017. Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery. BMC Medicine, 15 (1)
Hu, Jiamiao, Kyrou, Ioannis, Tan, Bee K., Dimitriadis, Georgios K., Ramanjaneya, Manjunath, Tripathi, Gyanendra, Patel, Vanlata H., James, Sean G., Kawan, Mohamed, Chen, Jing, Randeva, Harpal S., 2016. Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes. Endocrinology, 157 (5), pp. 1881-1894
Perry, David, Paulose Nadappuram, Binoy, Momotenko, Dmitry, Voyias, Philip D., Page, Ashley M., Tripathi, Gyanendra, Frenguelli, Bruno G., Unwin, Patrick R., 2016. Surface charge visualization at viable living cells. Journal of the American Chemical Society, 138 (9), pp. 3152-3160
Adaikalakoteswari, Antonysunil, Finer, Sarah, Voyias, Philip D., McCarthy, Ciara M., Vatish, Manu, Moore, Jonathan D., Smart-Halajko, Melissa, Bawazeer, Nahla M., Al-Daghri, Nasser M., McTernan, P. G., Kumar, Sudhesh, Hitman, Graham A., Saravanan, Ponnusamy, Tripathi, Gyanendra, 2015. Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clinical Epigenetics, 7 (1), pp. 1-14
Al-Disi, Dara, Al-Daghri, Nasser, Khan, Nasiruddin, Alfadda, Assim, Sallam, Reem, Alsaif, Mohammed, Sabico, Shaun, Tripathi, Gyanendra, McTernan, P. G., 2015. Postprandial effect of a high-fat meal on endotoxemia in Arab women with and without insulin-resistance-related diseases. Nutrients, 7 (8), pp. 6375-6389
Antonysunil, Adaikalakoteswari, Vatish, Manu, Lawson, Alexander, Wood, Catherine, Sivakumar, Kavitha, McTernan, P. G., Webster, Craig, Anderson, Neil, Yajnik, Chittaranjan S., Tripathi, Gyanendra, Saravanan, Ponnusamy, 2015. Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white caucasians living in the UK. Nutrients, 7 (4), pp. 2401-2414
Reddy, Narendra Lakshmana, Peng, C., Carreira, C., Halder, L., Hattersley, John G., Piya, Milan K., Tripathi, Gyanendra, Randeva, Harpal S., Casanueva, F. F, McTernan, P. G., Kumar, Sudhesh, Barber, T. M., 2015. Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Clinical Endocrinology, 82 (6), pp. 831-837
Al-Daghri, Nasser M., Al-Attas, Omar S., Alokail, Majed S., Alkharfy, Khalid M., Yousef, Mansour, Vinodson, Benjamin, Amer, Osama E., Alnaami, Abdullah M., Sabico, Shaun, Tripathi, Gyanendra, Piya, Milan K., McTernan, P. G., Chrousos, George P., 2014. Maternal inheritance of circulating irisin in humans. Clinical Science, 126 (12), pp. 837-844
Antonysunil, Adaikalakoteswari, Jayashri, Ramamurthy, Sukumar, Nithya, Venkataraman, Hema, Pradeepa, Rajendra, Gokulakrishnan, Kuppan, Anjana, Ranjit, McTernan, P. G., Tripathi, Gyanendra, Patel, Vinod, Kumar, Sudhesh, Mohan, Viswanathan, Saravanan, Ponnusamy, 2014. Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovascular Diabetology, 13 (1), pp. 1-7
Reddy, Narendra Lakshmana, Jones, Terence A., Wayte, Sarah C., Adesanya, Oludolapo, Sankar, Sailesh, Yeo, Yen C., Tripathi, Gyanendra, McTernan, P. G., Randeva, Harpal S., Kumar, Sudhesh, Hutchinson, Charles E., Barber, T. M., 2014. Identification of brown adipose tissue using MR imaging in a human adult with histological and immunohistochemical confirmation. The Journal of Clinical Endocrinology & Metabolism, 99 (1), pp. E117-E121
Piya, Milan K., Harte, A. L., Sivakumar, Kavitha, Tripathi, Gyanendra, Voyias, Philip D., James, S., Sabico, Shaun, Al-Daghri, Nasser M., Saravanan, Ponnusamy, Barber, T. M., Kumar, Sudhesh, Vatish, Manu, McTernan, P. G., 2014. The identification of irisin in human cerebrospinal fluid : influence of adiposity, metabolic markers, and gestational diabetes. AJP : Endocrinology and Metabolism, 306 (5), pp. E512-E518
Harte, A. L., Tripathi, G. N., Piya, Milan K., Barber, Thomas, Clapham, J. C., Al-Daghari, N., Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NFêB as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status and TNFá. Obesity, 21 (11), pp. 2322-2330
Harte, A. L., Tripathi, Gyanendra, Piya, Milan K., Barber, T. M., Clapham, John C., Al-Daghri, Nasser, Al-Disi, Dara, Kumsaiyai, Warunee, Saravanan, Ponnusamy, Fowler, Anne E., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2013. NF?B as a potent regulator of inflammation in human adipose tissue, influenced by depot, adiposity, T2DM status, and TNFa. Obesity research, 21 (11), pp. 2322-23300
Saboor Aftab, S. A., Reddy, Narendra Lakshmana, Owen, N. L., Pollitt, R., Harte, A. L., McTernan, P. G., Tripathi, Gyanendra, Barber, T. M., 2013. Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene manifesting clinically as osteogenesis imperfecta. Endocrinology, Diabetes & Metabolism Case Reports
Youssef-Elabd, Elham M., McGee, Kirsty C., Tripathi, Gyanendra, Al-Daghri, Nasser M., Abdalla, Mohga S., Sharada, Hayat M., Ashour, Esmat, Amin, Ashraf I., Ceriello, Antonio, O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., Harte, Alison L., 2012. Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro. Journal of Nutritional Biochemistry, Vol.23 (No.1), pp. 39-50
Harte, A. L., Varma, Madhusudhan C., Tripathi, Gyanendra, McGee, K. C., Al-Daghri, Nasser M., Al-Attas, Omar S., Sabico, Shaun, O'Hare, J. Paul, Ceriello, Antonio, Saravanan, Ponnusamy, Kumar, Sudhesh, McTernan, P. G., 2012. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care, Vol.35 (No.2), pp. 375-382
Metcalfe, David, Harte, Alison L., Aletrari, Mina Olga, Al Daghri, Nasser M., Al Disi, Dara, Tripathi, Gyanendra, McTernan, P. G., 2012. Does endotoxaemia contribute to osteoarthritis in obese patients?. Clinical science, Volulme 123 (11), pp. 627-34
Schisano, Bruno, Harte, Alison L., Lois, Konstantinos, Saravanan, Ponnusamy, Al-Daghri, Nasser M., Al-Attas, Omar S., Knudsen, Lotte B., McTernan, P. G., Ceriello, Antonio, Tripathi, Gyanendra, 2012. GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress. Regulatory Peptides, Vol.174 (No.1-3), pp. 46-52
Harte, Alison L., da Silva, Nancy F., Miller, Michelle A., Cappuccio, Francesco, Kelly, Ann M., O'Hare, J. Paul, Barnett, Anthony H., Al-Daghri, Nasser M., Al-Attas, Omar S., Alokail, Majed S., Sabico, Shaun, Tripathi, Gyanendra, Bellary, Srikanth, Kumar, Sudhesh, McTernan, P. G., 2012. Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus. Experimental Diabetes Research, Vol.2012
McGee, K. C., Shahmanesh, Mohsen, Boothby, Meg, Nightingale, Peter, Gathercole, Laura L., Tripathi, Gyanendra, Harte, Alison L., Shojaee-Moradie, Fariba, Umpleby, A Margot, Das, Satyajit, Al-Daghri, Nasser M., McTernan, P. G., Tomlinson, Jeremy W., 2011. Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones. Antiviral Therapy, 17 (3), pp. 495-507
Schisano, B., Tripathi, Gyanendra, McGee, K. C., McTernan, P. G., Ceriello, Antonio, 2011. Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells. Diabetologia, Vol.54 (No.5), pp. 1219-1226
Shirihai, Orian S., McGee, K. C., Harte, Alison L., da Silva, Nancy F., Al-Daghri, Nasser M., Creely, Steven J., Kusminski, Christine M., Tripathi, Gyanendra, Levick, Paul L., Khanolkar, Manish, Evans, Marc, Chittari, Madhu V., Patel, Vinod, Kumar, Sudhesh, McTernan, P. G., 2011. Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NF?B and JNK in human abdominal subcutaneous adipocytes. PLoS One, Vol.6 (No.6)
Alhusaini, S., McGee, K. C., Harte, A. L., McTernan, P. G., Kumar, Sudhesh, Tripathi, Gyanendra, 2010. Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress. Biochemical and Biophysical Research Communications, Vol.397 (No.3), pp. 472-478
Ramanjaneya, Manjunath, Chen, Jing, Brown, James E. P., Tripathi, Gyanendra, Hallschmid, Manfred, Patel, Suketu, Kern, Werner, Hillhouse, Edward W., Lehnert, Hendrik, Tan, Bee K., Randeva, Harpal S., 2010. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology, Vol.151 (No.7), pp. 3169-3180
Harte, A. L., da Silva, Nancy F., Creely, Steven J., McGee, K. C., Billyard, Thomas, Youssef-Elabd, Elham M., Tripathi, Gyanendra, Ashour, Esmat, Abdalla, Mohga S., Sharada, Hayat M., Amin, Ashraf I., Burt, Alastair D., Kumar, Sudhesh, Day, Christopher Paul, McTernan, P. G., 2010. Elevated endotoxin levels in non-alcoholic fatty liver disease. Journal of Inflammation, Vol.7
Al-Attas, Omar S., Al-Daghri, Nasser M., Alokail, Majed S., Alfadda, Assim, Bamakhramah, Ahmed, Sabico, Shaun, Pritlove, D. C., Harte, A. L., Tripathi, Gyanendra, McTernan, P. G., Kumar, Sudhesh, Chrousos, George P., 2010. Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs : the influence of circulating adiponectin. European Journal of Endocrinology, Vol.163 (No.4), pp. 601-607
Tripathi, Gyanendra, Salih, D. A. M., Drozd, A. C., Cosgrove, R. A., Cobb, L. J., Pell, J. M., 2009. IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo. The FASEB Journal, Vol.23 (No.8), pp. 2616-2626

Schisano, B., Tripathi, Gyanendra, Harte, A. L., McTernan, P. G., Knusden, L., Ceriello, Antonio, 2010. Liraglutide down regulates endoplasmic reticulum stress in human endothelial cells exposed to hyperglycaemia. 46th Annual Meeting of the European Association for the Study of Diabetes (EASD), Stockholm, Sweden, September 20-24, 2010, Published in Diabetologia, pp. S518-S518
Langowska, M., Alhusaini, S., McGee, K. C., Harte, A. L., McTernan, P. G., Kumar, Sudhesh, Tripathi, Gyanendra, 2010. Endoplasmic reticulum stress induced by hyperglycaemia and saturated fatty acids is alleviated by salicylates in cultured primary human adipocytes. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, Sweden, September 20-24, 2010, Published in Diabetologia
McGee, K. C., Tripathi, Gyanendra, Creely, S. J., Harte, A. L., Langowska, M., da Silva, N. F., Brown, A., Oscarsson, J., Clapham, J,, Kumar, Sudhesh, McTernan, P. G., 2010. Metabolic endotoxaemia as a mediator of mitochondrial dysfunction in human adipose tissue, alleviated by salicylate. 46th Annual Meeting of the European Association for the Study of Diabetes (EASD), Stockholm, Sweden, September 20-24, 2010, Published in Diabetologia, pp. S285-S285
Harte, A. L., Youssef-Elabd, E. M., McGee, K. C., Tripathi, Gyanendra, Abdalla, M. S., Sharada, H. M., Ashour, E., Amin, A. I., O'Hare, J. Paul, Kumar, Sudhesh, McTernan, P. G., 2010. Acute and chronic saturated fatty acid treatment as a key instigator of the TLR mediated inflammatory response in human adipose tissue in vitro. 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, Sweden, 20-24 Sep 2010, Published in Diabetologia
Alhusaini, S., Lois, Konstantinos, McGee, K. C., McTernan, P. G., Kumar, Sudhesh, Tripathi, Gyanendra, 2009. Endoplasmic stress is induced by lipopolysaccharides and high glucose and is alleviated by salicylates in cultured primary human adipocytes. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, SEP 30-OCT 02, 2009, Published in Diabetologia, pp. S51-S51
Schisano, Bruno, Radford, C. R., Harte, A. L., Tripathi, Gyanendra, McTernan, P. G., Ceriello, Antonio, 2009. A novel role for p53 in the regulation of oxidative stress in vascular cells in response to glucose fluctuation. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, SEP 30-OCT 02, 2009, Published in Diabetologia, pp. S501-S501
Tripathi, Gyanendra, Kusminski, C. M., Harte, A. L., McGee, K. C., O'Hare, J. Paul, McTernan, P. G., Kumar, Sudhesh, 2008. Obesity is associated with activation of innate immune pathway and ER stress in human abdominal subcutaneous adipose tissue. 43rd Annual Meeting of the European Association for the Study of Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S315-S315
Hill, M. J., McGee, K. C., Boothby, M., Higgins, P., Kusminski, C. M., Harte, A. L., Tripathi, Gyanendra, Gathercole, L. L., Kumar, Sudhesh, Shahmanesh, Mohsen, McTernan, P. G., 2007. The effect of HIV status and the impact of ARV therapy on mitochondrial metabolism in human adipose tissue. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, September 18-21, 2007, Published in Diabetologia, pp. S313-S313
McTernan, P. G., Hardo, F. J., Baker, A. R., McGee, K. C., Tripathi, Gyanendra, Creely, S. J., da Silva, N. F., Kumar, Sudhesh, Clapham, J. C., 2006. Expression of mitochondrial genes related to energy homoeostasis are dysregulated in obesity and type 2 diabetes. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen, Denmark, 14-17 Sep 2006, Published in Diabetologia, pp. 333-334

Title	Funder	Award start	Award end
The role of vitamin D deficiency in pregnant women and its association with gestational diabetes mellitus and impact on inflammation	King Saud University	30 Sep 2013	30 Sep 2017
The origins of inflammation in human adipocytes	King Saud University	01 Oct 2011	30 Sep 2015
Role of Endoplasmic Reticulum stress in inflammation, insulin resistance and Diabetes in cultured primary human adipocytes	Astrazeneca AB	01 Jul 2011	30 Jun 2015
King Saudi University Grant	King Saud University	01 Oct 2010	30 Sep 2014
Summer studentship (Alice Murphy): Regulation of endoplasmic reticulum stress pathways in human adipocytes	Society for Endocrinology	01 Jul 2013	31 Dec 2013
Role and regulation of inducible nitric oxide synthase (iNOS or NOS2) in diabetes	AstraZeneca	01 Feb 2011	31 Jan 2012
Novo Nordisk Continuation	Novo Nordisk A/S	01 Mar 2010	30 Sep 2010