Skip to main content

Dr Tinevimbo Shiri

 

Title   

Research Fellow
 

Contact   

WMS - Warwick Clinical Trials Unit
University of Warwick
Coventry
CV4 7AL
Tel: 02476575266
Email: T.Shiri@warwick.ac.uk

Research Interests

My interests focus on applying and developing statistical and computational models to better understand the dynamics of infectious pathogens and disease control, and evaluating the effectiveness of health interventions.

Current Research

  1. Reviewing literature on the impact of childhood pneumococcal conjugate vaccines on the epidemiology of pneumococcal carriage and disease (see our Review on the indirect effects of paediatric pneumococcal conjugate vaccines on invasive pneumococcal disease, with author supplied Supplementary Appendix and Supplementary Table of Study Characteristics).
  2. Developing nuanced transmission models of pneumococcal carriage and disease, pneumococcal disease hospitalisations and assessing the cost-effectiveness of different vaccination strategies

Previous Research

  1. Quantifying respiratory syncytial virus infection kinetics from in vitro and in vivo infections, and determining antiviral efficacy from clinical trials data
  2. Modelling pneumococcal carriage transmission between mother-child pairs and assessing the impact of childhood pneumococcal conjugate vaccines on pneumococcal carriage transmission trends in rural and urban households

Biography

Tinevimbo joined the Warwick Medical School - Clinical Trials Unit in July 2015, having previously worked in the Respiratory and Meningeal Pathogens Research Unit (RMPRU) at the University of the Witwatersrand, South Africa and in the Physical Modelling in Biology, Immunology and Ecology (PHYMBIE) research group at Ryerson University, Toronto, Canada. He was awarded his PhD in Computational and Applied Mathematics in 2011 from the University of the Witwatersrand. His current role within the Clinical Trials Unit is to undertake intensive research on the cost-effectiveness of interventions targeted at infectious diseases in England (see MEMVIE (Mathematical & Economic Modelling for Vaccination and Immunisation Evaluation) projects). He jointly works with a multidisciplinary team of modellers (Profs. Matt J. Keeling and Graham Medley), health economists (Profs. Stavros Petrou and Jason Madan), systematic reviewers (Drs. Pamela Royle and Alex Tsertsvadze ), and epidemiologists (Prof. Noel McCarthy).

Publications

Journals
  • Nzenze, Susan A., von Gottberg, Anne, Shiri, Tinevimbo, van Niekerk, Nadia, de Gouveia, Linda, Violari, Avy, Nunes, Marta C., Madhi, Shabir A., 2015. Temporal changes in pneumococcal colonization in HIV-infected and HIV-uninfected mother-child pairs following transitioning from 7-valent to 13-valent pneumococcal conjugate vaccine, Soweto, South Africa. The Journal of Infectious Diseases, 212 (7), pp. 1082-1092, View
  • Kwatra, G., Adrian, P. V., Shiri, Tinevimbo, Buchmann, E. J., Cutland, C. L., Madhi, S. A., 2015. Natural acquired humoral immunity against serotype-specific group B Streptococcus rectovaginal colonization acquisition in pregnant women. Clinical Microbiology and Infection, 21 (6), pp. 568.e13-568.e21, View
  • Nzenze, S. A., Shiri, Tinevimbo, Nunes, M. C., Klugman, K. P., Kahn, K., Twine, R., de Gouveia, L., von Gottberg, A., Madhi, S. A., 2014. Temporal association of infant immunisation with pneumococcal conjugate vaccine on the ecology of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonisation in a rural South African community. Vaccine, 32 (42), pp. 5520-5530, View
  • Kwatra , Gaurav, Adrian, Peter V., Shiri, Tinevimbo, Buchmann, Eckhart J., Cutland, Clare L., Madhi, Shabir A., 2014. Serotype-specific acquisition and loss of group B streptococcus recto-vaginal colonization in late pregnancy. PLoS One, 9 (6), View
  • Shiri, Tinevimbo, Nunes, Marta C., Adrian, Peter V., Van Niekerk, Nadia, Klugman, Keith P., Madhi, Shabir A., 2013. Interrelationship of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus colonization within and between pneumococcal-vaccine naà¯ve mother-child dyads. BMC Infectious Diseases, 13, View
  • Shiri, Tinevimbo, Auranen, Kari, Nunes, Marta C., Adrian, Peter V., van Niekerk, Nadia, de Gouveia, Linda, von Gottberg, Anne, Klugman, Keith P., Madhi, Shabir A., 2013. Dynamics of pneumococcal transmission in vaccine-naive children and their HIV-infected or HIV-uninfected mothers during the first 2 years of life. American Journal of Epidemiology, 178 (11), pp. 1629-1637, View
  • Nzenze, Susan A., Shiri, Tinevimbo, Nunes, Marta C., Klugman, Keith P., Kahn, Kathleen, Twine, Rhian, de Gouveia, Linda, von Gottberg, Anne, Madhi, Shabir A., 2013. Temporal changes in pneumococcal colonization in a rural African community with high HIV prevalence following routine infant pneumococcal immunization. The Pediatric infectious disease journal, 32 (11), pp. 1270-1278, View
  • Nunes, Marta C., Shiri, Tinevimbo, van Niekerk, Nadia, Cutland, Clare L., Groome, Michelle J., Koen, Anthonet, von Gottberg, Anne, de Gouveia, Linda, Klugman, Keith P., Adrian, Peter V., Madhi, Shabir A., 2013. Acquisition of Streptococcus pneumoniae in pneumococcal conjugate vaccine-naà¯ve South African children and their mothers. The Pediatric infectious disease journal, 32 (5), pp. e192-205, View

View All Publications

Update your user profile on Ideate https://warwick.tribalhosted.co.uk