RESEARCH PROFILE

The overall research interest of the laboratory is the regulation of fatty acid metabolism in health and disease, with particular emphasis on the changes related to insulin resistance and type-2 diabetes.

• The role of fatty acids in the control of insulin secretion, and disruption of insulin signalling
• Structure-function relationships of carnitine palmitoyltransferase 1 (CPT 1) and acetyl-CoA carboxylase 2 (ACC-2) with particular reference to the role of malonyl-CoA in the regulation of the intracellular content of long-chain acyl-CoA esters and products of their metabolism to complex lipids, in relation to the aetiology of insulin resistance and apoptosis
• The role of different diacylglycerol acyltransferases in the control, and cellular trafficking, of triacylglycerol in lipoprotein-secretory tissues
• The effects on acute hepatic insulin sensitivity of recurrent high-glycaemic intake

RESEARCH PROJECTS

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SELECTED PUBLICATIONS

• Moran, C.N., et al. (2011) 'Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors' Proceedings Of The Nutrition Society (OCE2), [article]
• Zammit, V. A. (2009) 'Recent drug development for diabetes and obesity' Primary Health Care 19 (6), 32 - 35
• Jenei, Z. A., Borthwick, K., Zammit, V. A. and Dixon, A. M. (2009) 'Self-association of transmembrane domain 2, but not TM1, in carnitine palmitoyltransferase 1A: role of GxxxG(A) motifs' Journal Of Biological Chemistry 284 (11), 6988 - 6997
• Arduini, A., Bonomini, M., Savica, V., Amato, A. and Zammit, V. (2008) 'Carnitine in metabolic disease: potential for pharmacological intervention' Pharmacology & Therapeutics 120 (2), 149 - 156
• Barwell, N. D., Malkova, D., Moran, C. N., Cleland, S. J., Packard, C. J., Zammit, V. A. and Gill, J. M. R. (2008) 'Exercise training has greater effects on insulin sensitivity in daughters of patients with type-2 diabetes than in women with no family history of diabetes' Diabetologia 51 (10), 1912 - 1919

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