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The positive-strand RNA viruses include a number of important human and veterinary pathogens including the picornaviruses (including enteroviruses and foot and mouth disease virus), hepatitis C virus, coronaviruses, caliciviruses (winter vomiting disease), dengue and yellow fever.  We study fundamental aspects of the biology of representative viruses within this group, with the long-term goal of understanding their replication, life cycle and evolution.  A better understanding of these characteristics will facilitate the development of novel therapeutic strategies to prevent or treat virus infection, as well as providing the essential insights into virus biology that will help our comprehension of future viral threats to human and animal health.

Our current research interest include:

1. the attachment and entry mechanism of enteroviruses
2. the replication of poliovirus
3. the role of cis-acting replication elements in the life-cycle of hepatitis C virus
4. the role of RNA structure in virus replication and evolution
5. the mechanism and consequences of virus recombination
   

This site contains details of our research activities and publications, funding, an overview of group membership, current vacancies and opportunities.  It also contains links to research resources, including bioinformatics software developed in-house and by our collaborators.  Some parts of the site are restricted to local access only.

Thank you for your interest in our research

David Evans 

See the lab refurbishment gallery ... it's now complete and occupied.  Though the air conditioning units still leak a bit ...