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GibsonGroup in Angewandte Chemie

The GibsonGroup's latest research into the use of biomaterials to increase the availability of donor cells has been published in Angewandte Chemie. Donor cells (e.g blood, bone marrow) are crucial to modern healthcare but due to their short shelf life they must be frozen using organic solvents as 'antifreezes'. The Gibson group has pionnered the use of synthetic polymers which inhibit ice crystal growth and their application to cryopreservation. In this work, a collaboraiton with Prof. Steve Armes at Sheffield, the team used biomimetic block copolymer micelles to provide a hydrated 'matrix' around the cells, which in combination with ice inhibiting polymers enable succesful cryopreservation of red blood cells. This is the first example of a cryopreservation system using entirely synthetic polymer materials, providing control and additional functionality into the system. Post-thawing, the micelles warm up, and become 'worm-like' which enabled the direct formation of a hydrogel, which is of interest for tissue engineering.

Read the paper here

Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells

Fri 29 Jan 2016, 10:28 | Tags: PolymerChem people publications MatPolymers ChemBio