Chemistry

Chemistry

Dr. Claudia Blindauer

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Dr. Claudia A. Blindauer
Associate Professor of Chemistry

Dipl.-Chem., PhD University of Basel, Switzerland

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Research Summary
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Inorganic biochemistry of metal-binding proteins from a variety of organisms including mammals, invertebrates, plants, and bacteria, with the aim to contribute to the understanding of mechanisms of metal ion homeostasis. Protein structure, dynamics of metal uptake and release, and biomolecular interactions are studied using recombinant protein expression and purification, multinuclear NMR, mass spectrometry, optical spectroscopies and multi-elemental analysis.
Selected Publications
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A molecular mechanism for modulating plasma Zn speciation by fatty acids.
J. Lu, A. J. Stewart, D. Sleep, P. J. Sadler, T. J. T. Pinheiro, and C. A. Blindauer. J. Am. Chem.Soc. 2012, 134, 1454–1457. DOI: 10.1021/ja210496n.
Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms.
O. I. Leszczyszyn, S. Zeitoun-Ghandour, S. R. Stürzenbaum and C. A. Blindauer. Chem. Commun., 2011, 47, 448-450. DOI: 10.1039/C0CC02188A.
The isolated Cys2His2 site in EC metallothionein mediates metal-specific protein folding.
O. I. Leszczyszyn, C. R. J. White and C. A. Blindauer, Mol. BioSyst. 2010, 6, 1592-1603.

Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more.
C. A. Blindauer, O. I. Leszczyszyn, Nat. Prod. Rep. 2010, 27, 720-741.

Structure, Properties, and Engineering of the Major Zinc Binding Site on Human Albumin.
C.A. Blindauer, I. Harvey, K.E. Bunyan, A.J. Stewart, D. Sleep, D.J. Harrison, S. Berezenko, P.J. Sadler, J. Biol. Chem. 2009, 284, 23116-23124.
Page contact: Giovanni Costantini Last revised: Mon 30 Jan 2012
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