Chemistry

Chemistry

Greg Challis

challis.jpg

Prof. Gregory L. Challis
Professor of Chemical Biology

BSc, DPhil, FRSC, FSB

Group
Site

 

Contact
Details

spacer.jpg
Research Summary
grey-line-1.jpg

Natural products chemistry and biology, including isolation and structure determination of new bioactive natural products, genomics and genetics of natural product biosynthesis, enzymology of natural product biosynthesis, chemical synthesis of bioactive natural products and intermediates in their biosynthesis, genetic manipulation of bioactive natural product biosynthesis pathways to produce new analogues, molecular mechanism of action of bioactive natural products and their biological function. A highly multidisciplinary approach to these problems is taken encompassing high field NMR spectoscopy, mass spectrometry, HPLC, organic synthesis, bioinformatics, microbiological methods, molecular genetic manipulation, recombinant protein overproduction and purification, and enzyme assay development.
Selected Publications
grey-line-1.jpg
Regio- and stereodivergent antibiotic oxidative carbocyclizations catalyzed by Rieske oxygenase-like enzymes.
P.K. Sydor, S. M. Barry, O.M. Odulate, F. Barona-Gomez, S.W. Haynes, C. Corre, L. Song, and G.L. Challis. Nat. Chem. 2011, 3, 388-392.

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.
L. Laureti, L. Song, S. Huang, C. Corre, P. Leblond, G.L. Challis and B. Aigle. Proc. Natl. Acad. Sci. USA, 2011, 108, 6258-6263.

AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.
S. Schmelz, N. Kadi, S.A. McMahon, L. Song, D. Oves-Costales, M. Oke, H. Liu, K.A. Johnson, L.G. Carter, C.H. Botting, M.F. White, G.L. Challis, J.H. Naismith. Nat. Chem. Biol. 2009, 5, 174-182.

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining.
C. Corre, L. Song, S. O'Rourke, K.F. Chater, G.L. Challis. Proc. Natl. Acad. Sci. USA. 2008, 105, 17510-17515.

A new family of ATP-dependent oligomerization-macrocyclization biocatalysts.
N. Kadi, D. Oves-Costales, F. Barona-Gomez and G.L. Challis. Nat. Chem. Biol. 2007, 3, 652-656.

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining.
S. Lautru, R.J. Deeth, L.M. Bailey, and G.L. Challis. Nat. Chem. Biol. 2005, 1, 265-269.
Page contact: Emily Harding Last revised: Sat 30 Apr 2011
Back to top of page
 

Web site search

People search

News

News.