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Dr. Christophe Corre
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Dr. Christophe Corre
Royal Society Research Fellow
MSc (Nice), PhD (Exeter)
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Research Summary
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Bacterial signalling: new chemical keys to unlock the production of novel microbial antibiotics.
- Understanding the transcriptional regulation of antibiotic biosynthesis in actinomycete bacteria, from which more than 70% of clinically-approved antibiotics originate.
- Exploiting signalling molecules (microbial hormones) to induce production of novel antibiotics in the laboratory environment
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Selected Publications
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A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols.
C. Corre, S.W. Haynes, N. Malet, L. Song, and G.L. Challis. Chem. Commun., 2010, 46, 4079-4081.
Exploiting genomics for new natural product discovery in prokaryotes. C. Corre and G.L. Challis. In Comprehensive Natural Products Chemistry II Chemistry and Biology
Mander, L., Liu, H.-W., Eds.; Elsevier: Oxford, 2010; volume 2, pp.429-453.
New natural product biosynthetic chemistry from genome mining
C. Corre and G.L. Challis. Nat. Prod. Rep., 2009, 26, 977-986
2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining
C. Corre, L. Song, S. O'Rourke, K.F. Chater, G.L. Challis. Proc. Nat. Acad. Sci. USA. 2008, 105, 17510-17515.
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