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Dr David Fox

Dr David J. Fox

Associate Professor

B.A. D.Phil.





Research Summary

Synthetic organic and medicinal chemistry

- Drug Discovery for inflammatory diseases, such as for asthma, and degenerative and metabolic diseases.

- Synthetic methodology including asymmetric and catalytic reactions, kinetics and DFT modelling.

Selected Publications
Perryman, Michael S.; Harris, Matthew E.; Foster, Jade L.; Joshi, Anushka; Clarkson, Guy J.; Fox, David J. Chem Commun., 2013, 49, 10022-10024. DOI:10.1039/c3cc46070c This paper was highlighted in Synfacts 2014, 10, 175. DOI:10.1055/s-0033-1340532

Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study Morrill, Louis C.; Douglas, James; Lebl, Tomas; Slawin, Alexandra M. Z.; Fox, David J.; Smith, Andrew D. Chemical Science, 2013, 4, 4146-4155. DOI:10.1039/c3sc51791h

Iron/Tetramethylethylenediamine-Catalyzed Ambient-Temperature Coupling of Alkyl Grignard Reagents and Aryl Chlorides Rushworth, Philip J.; Hulcoop, David G.; Fox, David J. J. Org. Chem., 2013, 78, 9517-9521. DOI: 10.1021/jo4016612

Highly potent, orally-available anti-inflammatory broad-spectrum chemokine inhibitors
D.J. Fox, J. Reckless, H. Lingard, S. Warren and D.J. Grainger, J. Med. Chem. 2009, 52, 3591–3595. DOI: 10.1021/jm900133w

Mechanism of Catalytic Cyclohydroamination by Zirconium Salicyloxazoline Complexes
L. E. N. Allan, G. J. Clarkson, D. J. Fox, A. L. Gott, and P. Scott, J. Am. Chem. Soc., 2010, 132, 15308–15320. DOI: 10.1021/ja106588m