Dr David J. Fox

B.A. D.Phil.

Research Summary

1) Medicinal chemistry - drug discovery, such as clinical candidate FX125L for inflammatory diseases such as for asthma and related conditions,  and the development of mechanistic probes for the discovery of new biological mechanisms.

Selected Publications

Mechanism of Catalytic Cyclohydroamination by Zirconium Salicyloxazoline Complexes
L. E. N. Allan, G. J. Clarkson, D. J. Fox, A. L. Gott, and P. Scott, '' J. Am. Chem. Soc., 2010, 132, 15308–15320. DOI: 10.1021/ja106588m

Highly potent, orally-available anti-inflammatory broad-spectrum chemokine inhibitors.
D.J. Fox, J. Reckless, H. Lingard, S. Warren and D.J. Grainger, ’ J. Med. Chem. 2009, 52, 3591–3595.

The lithiation and acyl transfer reactions of phosphine oxides, sulfides and boranes in the synthesis of cyclopropanes.
C. Clarke, D.J. Fox, D. Sejer Pedersen and S. Warren Org. Biomol. Chem. 2009, 7, 1329 - 1336.

An Investigation into the Tether Length and Substitution Pattern of Arene-Substituted Complexes for Asymmetric Transfer Hydrogenation of Ketones. F.K. Cheung, C. Lin, F. Minissi, A. Lorente, M.A. Graham, D.J. Fox and M. Wills, Org. Lett., 2007, 9, 4659-4662.