Organic Synthesis: Mechanism and Applications

We are interested in synthetic and mechanistic organic chemistry. Our research covers a range of subjects, generally in these areas:

- Synthetic drug discovery, lead optimisation and development. The development of mechanistic probes for the discovery of new biological mechanisms and natural product synthesis. Discovery and development of FX125L (with Funxional Therapeutics) and new pro-autophagy agents (with TCP innovations).

- Asymmetric and catalytic reaction discovery and development. Mechanistic investigation and optimisation using kinetics and computation. We are interested in carbon-carbon bond formation and reduction using 1st and 2nd row transition metal catalysts (Fe, Cu, Ru) and organocatalysts. Translational synthesis, extending and improving existing methodology for the creation of new medicinal compounds and synthetic routes (with GSK).

For more information click these links:

Medicinal chemistry 

Mechanistic catalysis 

Mechanism modelling

	David Fox at the biotech blog DrugBaron on how to improve drug discovery here.
	David Fox at The Huffington Post on "olympicene" here.