Dr. Matthew I. Gibson

MChem(Hons) and Ph.D (Dunelm)

Research Summary

Design of membrane-interacting macromolecules to aid in cryopreservation, specific membrane disruption or to trigger cellular uptake. We are also developing environmentally responsive polymers and nanoparticles as well as (glyco)polymers for targetted delivery of therapeutics and to prevent/treat infection. The work is highly interdisciplinary crossing the boundaries of fundamental organic and polymer chemistry with the life sciences

Selected Publications

Degradable Thermoresponsive Polymers which Display Redox-Responsive LCST Behaviour
Phillips, D.J., Gibson, M. I.,Chemical Communications, 2012,48 1054 - 1056.

The critical importance of size on thermoresponsive nanoparticle transition temperatures: gold and micelle-based polymer nanoparticles
Ieong, N.S., Bebis, K., Daniel, L. E., O'Reilly, R.K., Gibson, M. I., Chemical Communications, 2011, 47, 11627 - 11629.

Optimised ‘Click’ Synthesis of Glycopolymers with mono/di and trisaccharides
Vinson, N., Gou, Y., Bercer, C. R., Haddleton, D. M., Gibson, M. I., Polymer Chemistry, 2011, 2, 107 - 113,

High Affinity Glycopolymer Binding to Human DC-SIGN and Disruption of DC-SIGN Interactions with HIV Envelope Glycoprotein
Bercer, C. R., Gibson, M. I., Ilyas, R., Geng, J., Wallis, R., Mitchel, D. A., Haddleton, D. M., Journal of the American Chemical Society, 2010, 132, 15130-15132

Size Dependant LCST Transitions of Polymer-Coated Gold Nanoparticles: Co-operative Aggregation and Surface Assembly
Gibson, M.I., Paripovic, D., Klok, H.-A., Advanced Materials, 2010, 22, 4721- 4725

Slowing the Growth of Ice with Synthetic Macromolecules: Beyond Antifreeze(glyco) Proteins
Gibson, M.I., Polymer Chemistry, 2010, 1, 1141-1152, Featured on the Front Cover