Gibson Group News
Dr Matt Gibson Awarded PAT 'Young Talent' Award 2015
At the 13th PAT (Polymers for Advanced Technology) conference, in HongZhou (China) Matt was awarded the Young Talent award for outstanding research for an academic < 40 years old. He was selected from a shortlist of 5, including academics from USA, Europe and China.
Matt also delivered an invited lecture at the meeting.
Tom Congdon becomes a Dr!
Tom Congdon, co-supervised by Dr R. Notman has become the 4th member of the group to pass his PhD viva. His Thesis focussed on the synthesis and application of polymeric ice recrystalisation inhibitors; inspired by how antifreeze glycoproteins function. Tom also made signficant contributions to the design of new thermoresponsive polymers based upon intrinsically biocompatible scaffolds - namely carbohydrates and poly(vinyl alcohol)
Read some of this papers here;
Congdon, T., Shaw P., Gibson, 2015, Polymer Chemistry, 'Thermoresponsive, Well-defined, poly(vinyl alcohol) co- polymers' Accepted Link
Congdon, TR, Wilmet, C., Williams, R., Polt, J., Lilliman, M., and Gibson, M.I., Eur. Polym. J., 2015, 62, 352 - 362, "Functionalised Carbohydrate-Centred Oligomers and Polymers. Thermoresponsivity, Lectin Binding and Degradability"
Congdon, TC, Notman, R., Gibson, MI, Biomacromolecules, 2013, 14, 1578 - 1586 "Antifreeze (Glyco)Protein Mimetic Behaviour of Poly(vinyl alcohol): Detailed Structure-Ice Recrystallisation Inhibition Activity Study" link
Deller, R.C., Congdon, T., Sahid, M., Morgan, M., Vatish, M., Mitchell, D.A., Notman, R., Gibson, M.I., Biomater. Sci., 2013, 1, 478 - 485 "Ice recrystallisation inhibition by polyols: comparison of molecular and macromolecular inhibitors and role of hydrophobic units" Link
Paper Accepted in RSC Advances
Our latest paper has been accepted in RSC Advances. This paper describes our attempts to specfically identifiy lectins associated with bacterial infection and virulence. Lectins are proteins which bind glycans, but are famously promiscuous - any lectin can bind a range of sugars, and vice versa, making sensing them challenging. Current methods rely on protemics (e.g. expensive mass spec) or antibody based strategies - neitehr of these are useful for point of care diagnostics. Here we take an approach inspired by Tongues - these only have 5 different inputs, but can discriminate between a range of tastes by a combination of multiplexing (measuring relative response of each input) and training. Using just 3 simple monosaccharide surfaces we could profile and identify between 5 lectins which all 'bind' galactose. This includes the cholera toxin and a surrogate for ricin - a potential biological warefare agent.
Read the paper here:
Discrimination between Lectins with Similar Specificities by Ratiometric Profiling of Binding to Glycosylated Surfaces; A Chemical ‘Tongue’ Approach
Matt Gibson interviewed for BBC radio
As part of his appearance at the Cheltenham festival of Science, Matt was interviewed by BBC radio Gloucester. Tune in later this week to hear the interview. (including the important of a Gin and Tonic to understand the challenges of cryopreserving human tissue..)
Paper published in Polymer Chemistry
Our latest paper has been published in the RSC Journal Polymer Chemistry. 'Thermoresponsive, well-defined, poly(vinyl alcohol) co-polymers'
This papers builds on our previous work in the design and application of biologically-responsive polymers. Most responsive polymers are based on polymers which are assumed to be biocompatiable, but are not used clinically. PVA (poly(vinylalcohol)) however, is widely used in healthcare settings such as eye drops, or pharmaceutical coatings. Therefore, we set out to modify this to make it environmentally responsive (in this case temperatur). Using RAFT polymerization, we made a library of well-defined PVA's and then modifed them with ester side chains, enabling us to precisely control the transition temperature. We think that by basing this on such a well-known and biocompatible polymer we might be able to aid translation of responsive polymers
Read the paper here;
Matt speaks at the Cheltenham Festival of Science
Matt Gibson gave a lecture at the Cheltenham Festival of Science (one of the biggest such festivals in the UK). His talk was entitled 'How to Freeze a Human'. In this, he explored the concept of cryopreservation - freezing of tissue and the challenges around this. This included a discussion of just how complex water and ice are - including demonstrations from smashing frozen bananas to using a hammer to nucleate (promote) ice formation...
Robert Deller wins best Thesis Prize
Robert Deller (Now PDRA in Bristol) won the Chemistry Department Prize for best Thesis, at the annual postgraduate sympoisum. His Thesis was entitled 'The investigation and application of ice recrystalisation inhibitors as novel cryoprotectants for biological materials'. Rob was co-supervised by Dr Daniel Mitchell (Warwick Medical School) and Dr Manu Vatish (Now Oxford).
PhDs Available now!
See the advert here