Gibson Group News
GibsonGroup work on Front cover of Biomaterials Science
Our recent paper describing the synthesis and testing of new antifreeze-protein mimetic polymers has been highlighted on the front cover of the RSC journal Biomaterials Science.
And the paper here
Carbohydrate Research Paper Published
Our latest paper probing the biological function and utility of glycosylated (sugar-functionalized) materials have been published in Carbohydrate Research, in a special issue on Nanomaterials. This work seeks to understand the potential therapeutic use of glucose-functional nanoparticles/polymers. Glucose polymers and particles have been indicated to be useful as alternatives to PEGylation, but there remains unsolved questions about their unwanted interactions with other biological systems; particularly the immune system, but also cell-surface glucose transporters (on every cell in your body!). Here we investigated how glucose materials interact with red blood cells (the cell they are most likely to encoutner when applied therapeutically). We found no evidence for either binding nor aggutination, suggesting the materials are biocompatible, at least in this model.
This work was conducted in collaboration with Gemma Davies
Matt Gibson discusses antifreeze proteins in COSMOS magazine
Matt was recently invited to discuss an exciting area of reserach for the Australian science Magazine, COSMOS. IN this Matt summarised a recent report which found that antifreeze proteins appear to not only modulate the growth of ice, but also sugars. This finding has both interesting applications in controlled crystal polymorph, for example, but also in explaining how antifreeze proteins differentiate between water, ice and sugar, which are all chemically very similar, in that they present surfaces rich in hydroxyl groups.
Matt Gibson Interviewed in Chem. Eng. News
The Group's work on antifreeze protein-mimetic polymers to enhance cellular cryopreservation has been featured in the American Chemical Society's magazine Chemical and Engineering News.
Read the full story here (login required)
New Lab photos online
Paper published in Biomaterials Science
Our latest paper has been published in Biomaterials science, in Collaboration with Steve Edmonson, Manchester Uni. This papers describes the fabrication of carbohydrate (glycan) coated glass slides using thiol-ene chemistry (sometimes call thiol-ene click). A key challenge in assembling carbohydrates onto surfaces is ensuring their presentation and connectivity (i.e orientation) and mimimising the synthetic steps required. Thiolyated sugars are widely used to attached to gold surfaces for SPR, but this can be very expensive. Our approach involves coating glass slides with acrylates to enable conjguation of the sugars, which can then be applied to conventional microarrays.
Read the paper here
ACS Macro Letters Paper Published
Our latest paper on developing new biosensors for carbohydrate binding toxins has been published in ACS Macroletters, based on work by Sarah-Jane.
In this work we study the effect of the polymer spacer - between the biosensory unit (gold nanoparticle) and bio-recognition unit (carbohydrate). We show that the polymer length must be just right; not too long. Not too short. This ensures stability in complex media (saline etc) and but also ensures that upon binding we see a rapid colour change from red to blue. These partilces may find use in point-of-care diagnostics in low resource environments.
Read the paper here http://pubs.acs.org/doi/abs/10.1021/mz5004882
Biomaterials Science Paper Published
Our new paper described the synthesis and testing of new ice-inhibiting cryoprotective polymers has been published in the RSC Journal Biomaterials Science. This paper describes the study of poly(ampholytes), mixed charge polymers, which can slow ice growth. This is only the second ever class of polymers with definate IRI activity.
Read the paper here.