Gibson Group News
Interview with MIG for Noreen Murrary Award Online
Watch/Listen to MIG discussing how philanphropic donations can make a huge difference to ambitious research projects.
We have a 6 month, fixed term PDRA position available in the group to start immediately.
The position will involve investigating the cryopreservation of tissue for transplantation, using our new technology inpsired by antifreeze glycoproteins. See our recent Nature Communications paper for background;
Deller, R.C., Vatish, M., Mitchell, D.A., Gibson, M.I., Nature Communications, 2014, 5, 3244, "Synthetic polymers enable non-vitreous cellular cryopreservation by reducing ice crystal growth during thawing" online link
Article Published in Chemical Science
With the increase in the number of pathogens displaying resistance to conventional antibiotics new tools are urgently required. To address this, the GibsonGroup have been developing polymers which specifcally target the toxins (which cause all the physical symptons) secreted by pathogenic bacteria with the aim of neutralizing them. This route does not kill the bacteria and hence should not apply evolutionary pressure, and hence not induce resistance. In this work, glycopolymers which are highly specific have been demonstrated - nearly all previous reports of glycopolymers only demonstrate affinity, but for real-world applications, these must be highly selective to reduce side-effects and to maximise efficacy. This work was conducted in collaboration with the Haddleton Group.
Read the paper here in Chemical Science. Glycopolymers with secondary binding motifs mimic glycan branching and display bacterial lectin selectivity in addition to affinity
In collaboration with Del Besra (Bham) and Liz Fullam (Life Science), we describe the design, synthesis and application of glycosylated nanoparticles for specific interaction with bacterial phenotypes. The nanoparticles have sugar on their surface which interest specifically with the FimH adhesion present on certain pathogenic strains of bacteria. In this paper we probe the role of the polymer coating on the optical outputs (colour change) of the nanoparticles, as the first steps towards a rapid point-of-care sensor for bacteria.
GibsonGroup in the Media
Our recent paper on cryopreservaiton of blood has attracted a lot of media attention:
Nature Communications Article Published
Research conducted by Rob (PhD student) in collaboration with Dan Mitchel (Warwick Med School) and Manu Vatish (Formally Warwick Med School and Coventry Hospital) has been published in Nature Communications.
A joint publication with Alison Rodger and Nicola Chmel has been published in The Analyst. This paper describe the use of poly(ethylene) fims to align small polar molecules for linear Dichroism spectroscopy.
Robert Deller (re)joins us as PDRA
Robert Deller is staying with us to work as PDRA, now his Thesis is submitted. He will continue our cryopreervation work and also new sensory systems. Good to have you back!