Prof. David M. Haddleton

BSc, DPhil York

Head of Inorganic and Materials Section

Research Summary

New methods of polymer synthesis and catalysis. Specific interests include controlled polymerisation of acrylics and esters by organometallic initiators and catalysts, e.g. atom transfer living polymerisation, catalytic chain transfer polymerisation. Mechanisms of polymerisation and utilisation of this knowledge to design catalysts and organic polymers for specific commercial applications. Environmentally friendly polymerisation and use of biomimetic chemistry in this area.

Selected Publications

Tunable thermo-responsive polymer-protein conjugates via a combination of nucleophilic thiol-ene "click" and SET-LRP
 Jones Mathew W.; Gibson Matthew I.; Mantovani Giuseppe; Haddleton David M. POLYMER CHEMISTRY 2011, 2, 572-574, DOI: 10.1039/c0py00329h 

Synthesis and modification of thermoresponsive poly(oligo(ethylene glycol) methacrylate) via catalytic chain transfer polymerization and thiol-ene Michael addition
Soeriyadi Alexander H.; Li Guang-Zhao; Slavin Stacy; Haddleton David M. et al. POLYMER CHEMISTRY 2011, 2, 815-822 DOI: 10.1039/c0py00372g 

Glycopolymers via catalytic chain transfer polymerisation (CCTP), Huisgens cycloaddition and thiol-ene double click reactions
L. Nurmi, J. Lindqvist, R. Randev, J. Syrett and D. M. Haddleton, Chemical Communications, 2009, 19, 2727-2729

Advances in PEGylation of important biotech molecules: delivery aspects
S. M. Ryan, G. Mantovani, X. X. Wang, Haddleton, D. M. And D. J. Brayden, Expert Opinion on Drug Delivery, 2008, 5, 371-383

High-Affinity Glycopolymer Binding to Human DC-SIGN and Disruption of DC-SIGN Interactions with HIV Envelope Glycoprotein
Becer C. Remzi; Gibson Matthew I.; Geng Jin; Haddleton, David M. et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2010, 132, 15130-15132, DOI: 10.1021/ja1056714