Dr. Andrew Marsh

B.Sc., Ph.D. (London), MRSC, CChem

Research Summary

Combining organic chemistry and molecular design in the synthesis of functional molecules. Understanding how the molecules we make interact with each other and with biological targets. Synthesis of heterocycles and nucleobase analogues that are able to self-assemble using hydrogen bonds and other non-covalent interactions. Discovery of protein targets for known bioactive molecules using phage display and affinity methods. Synthetic and biomolecular interactions using physico-chemical techniques including isothermal titration calorimetry, gel permeation chromatography and NMR methods.

Selected Publications

Using the DC-SIGN & Man₉(GlcNAc)₂ pairing to probe specificity in photochemical immobilization

A J Clark, S J Dilly, D Mitchell,* A Marsh* P C Taylor* Mol. Biosyst. 2011, 7, 116-118.

Personalized medicine - the impact on chemistry

J Watkins, A Marsh, P C Taylor, D R Singer, * Therapeutic Delivery 2010, 1, 651-665.

Apparent non-statistical binding in a ditopic receptor for guanosine
A Likhitsup, R J Deeth, S Otto, A Marsh* Org. Biomol. Chem. 2009, 2093-2103.

Rapid Identification of a Putative Interaction between β2-Adrenoreceptor Agonists and ATF4 using a Chemical Genomics Approach
S R Ladwa,* S J Dilly, A J Clark, A Marsh, P C Taylor* ChemMedChem, 2008, 3, 742-744. Featured cover art. DOI: 10.1002/cmdc.200890018.

A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery
S J Dilly, M J Bell, A J Clark, A Marsh,* R M Napier, M J Sergeant, A J Thompson, P C Taylor* Chem. Commun. 2007, 2808-2810.

Function and Stability of Abscisic Acid Acyl Hydrazone Conjugates by LC-MS2 of ex vivo Samples
T R Smith, A J Clark, R M Napier, P C Taylor, A J Thompson, A Marsh* Bioconjugate Chemistry, 2007, 1355-1359.

Concise Enantioselective Synthesis of Abscisic Acid and a New Analogue
TR Smith, AJ Clark, GJ Clarkson, PC Taylor, A Marsh* Org. Biomol. Chem. 2006, 4, 4186.

Novel Tertiary Amine Oxide Surfaces That Resist Nonspecific Protein Adhesion
Dilly SJ, Beecham MP, Brown SP, Griffin JM, Clark AJ, Griffin CD, Marshall J, Napier RM, Taylor PC, Marsh* A Langmuir 2006, 22, 8144.