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Prof. Peter O'Connor

Peter B. O

Prof. Peter O'Connor

Professor of Analytical Chemistry

Ph.D. Cornell University, Ithaca, NY, USA

B.Sc. University of North Texas, Denton, Tx, USA

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Research Summary
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Improving the performance and applications of Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometers. We work collaboratively with other research groups to demonstrate the effectiveness of higher specification FTICR mass spectrometry in specific applications. Particular focus in recent years has been on fundamental studies of the mechanism of electron capture dissociation, FTICR instrument design, post-translational modification analysis of proteins and peptides, deamidation and isomerization of aspartic acid residues in peptides and proteins, etc.

Selected Publications
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1. Wei, J.; Antzutkin, O. N.; Filippov, A. V.; Iuga, D.; Lam, P. Y.; Barrow, M. P.; Dupree, R.; Brown, S. P.; O'Connor, P. B., Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State NMR and Ultra-High Resolution FTICR-MS. Biochemistry 2016, 55 (14), 2065-2068.

2. Simon, H. J.; van Agthoven, M. A.; Lam, P. Y.; Floris, F.; Chiron, L.; Delsuc, M. A.; Rolando, C.; Barrow, M. P.; O'Connor, P. B., Uncoiling collagen: a multidimensional mass spectrometry study. Analyst 2016, 141 (1), 157-165.

3. Agthoven, M. A. v.; Chiron, L.; Coutouly, M.-A.; Wootton, C. A.; Soulby, A.; Wei, J.; Barrow, M. P.; Delsuc, M.-A.; Rolando, C.; O'Connor, P. B., Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with Cytochrome c. Anal Chem 2016, 88 (8), 4409-4417.

4. Wootton, C. A.; Sanchez-Cano, C.; Liu, H.-K.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B., Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry. Dalton Transactions 2015, 44 (8), 3624-3632.

5. Soulby, A. J.; Heal, J. W.; Barrow, M. P.; Roemer, R. A.; O'Connor, P. B., Does deamidation cause protein unfolding? A top-down tandem mass spectrometry study. Protein Science 2015, 24 (5), 850-860.