Prof. Peter Sadler

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Prof. Peter J. Sadler
Professor of Chemistry

MA, DPhil (Oxon), FRS, FRSE

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Research Summary
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Chemistry of metals in medicine (bioinorganic chemistry, inorganic chemical biology and medicine). Design and chemical mechanism of action of therapeutic metal complexes, including organometallic arene anticancer complexes, photoactivated metal anticancer complexes (for photochemotherapy), metallomacrocycles as antivirals and stem-cell-mobilising agents, and metalloantibiotics. Besides synthesis of co-ordination complexes, research involves studies of interactions with targets such as RNA, DNA and proteins, and often industrial and international interdisciplinary collaborations.
Selected Publications
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Catalytic organometallic anticancer complexes.
S.J. Dougan, A. Habtemariam, S.E. McHale, S.Parsons, P.J. Sadler, Proc. Natl. Acad. Sci. USA. 2008, 105, 11628-11633

A potent cytotoxic photoactivated platinum complex.
F.S. Mackay, J.A. Woods, P. Heringová, J. Kaspárková, A.M. Pizarro, S.A. Moggach, S. Parsons, V. Brabec, P.J. Sadler, Proc. Natl. Acad. Sci. USA. 2007, 104, 20743-20748.

Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity.
F. Wang, A. Habtemariam, E.P.L. van der Geer, R. Fernández, M. Melchart, R.J. Deeth, R. Aird, S. Guichard, F.P.A. Fabbiani, P. Lozano-Casal, I.D.H. Oswald, D.I. Jodrell, S. Parsons, P.J. Sadler, Proc. Natl. Acad. Sci. USA. 2005, 102, 18269-18274.

Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme.
T.M. Hunter, I.W. McNae, X. Liang, J. Bella, S. Parsons, M.D. Walkinshaw, P.J. Sadler, Proc. Natl. Acad. Sci. USA. 2005, 102, 2288-2292.