Chemistry of metals in medicine (bioinorganic chemistry, inorganic chemical biology and medicine). Design and chemical mechanism of action of therapeutic metal complexes, including organometallic arene anticancer complexes, photoactivated metal anticancer complexes (for photochemotherapy), metallomacrocycles as antivirals and stem-cell-mobilising agents, and metalloantibiotics. Besides synthesis of co-ordination complexes, research involves studies of interactions with targets such as RNA, DNA and proteins, and often industrial and international interdisciplinary collaborations.
The Potent Oxidant Anticancer Activity of Organoiridium Catalysts.
Z. Liu, I. Romero-Canelón; B. Qamar, J.M.Hearn, A. Habtemariam, N.P.E. Barry, A.M. Pizarro, G.J. Clarkson, P.J. Sadler
De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
Y. Zhao, N.J. Farrer, H. Li, J.S. Butler, R.J. McQuitty, A. Habtemariam, F. Wang, P.J. Sadler
Angew. Chem. Int. Ed.2013, 52, 13633-13637.
Challenges for Metals in Medicine: How Nanotechnology May Help to Shape the Future
N.P.E. Barry, P.J. Sadler
ACS Nano 2013, 7, 5654-5659.
Next generation metal anticancer complexes: Multi-targeting via redox modulation
I. Romero-Canelón, P.J. Sadler
Inorg. Chem. 2013, 52, 12276–12291.
Cancer chemistry: designing new drugs for cancer treatment.
A.M. Pizarro, P.J. Sadler
Ch.15 pp 438-460. Biologically targeted agents from bench to besideM. Khan, P.J.Sadler, A.M. Pizarro, S. Pelengaris. Ch.16, pp 461-508 in The Molecular Biology of Cancer. A bridge from bench to bedside. S, Pelengaris and M. Khan eds., 2nd ed. Wiley-Blackwell, 2013
Metal–DNA Coordination Complexes
A.M. Pizarro, N.P.E. Barry, P.J. Sadler
In: Jan Reedijk and Kenneth Poeppelmeier, editors. Comprehensive Inorganic Chemistry II, Vol 3. Oxford: Elsevier; 2013, p. 751-784.
Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes.
Z. Liu, R.J. Deeth, J.S. Butler, A. Habtemariam, M.E. Newton, P.J. Sadler
Angew. Chem. Int. Ed. 2013, 52, 4194-4197.
Tryptophan Switch for a Photoactivated Platinum Anticancer Complex.
J.S. Butler, J.A. Woods, N.J Farrer, M.E. Newton, P.J. Sadler
J. Am. Chem. Soc. 2012, 134, 16508-16511.
Two-photon-activated ligand exchange in platinum(II) complexes.