Prof. Mike Shipman

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Prof. Mike Shipman
Professor of Synthetic Chemistry

B.Sc., Ph.D. (London), MRSC, CChem

Head of Department

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Research Summary
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Development of new methods for the construction of organic compounds and their use in the preparation of a diverse range of functional molecules. These include: the preparation of anticancer and antibiotic natural products and the study of their mode of action; the synthesis and evaluation of new materials that act as molecular switches; the development of new chemistry for the rapid and efficient assembly of organic molecules. Much of our work involves the use and/or study of strained heterocyclic ring systems.
Selected Publications
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Aziridine Scaffolds for the Detection and Quantification of Hydrogen-Bonding Interactions through Transition-State Stabilization
L. Giordano, C.T. Hoang, M. Shipman, J.H.R. Tucker, T.R. Walsh, Angew. Chem. Int. Ed. 2011, 50, 741-744.

Tetrahydroxanthones by Sequential Pd-Catalyzed C−O and C−C Bond Construction and Use in the Identification of the “Antiausterity” Pharmacophore of the Kigamicins  
P. A. Turner, E. M. Griffin, J. L. Whatmore, M. Shipman, Org. Lett. 2011, 13, 1056-1095.

Synthesis and Functionalization of 3-Alkylidene-1,2-diazetidines Using Transition Metal Catalysis
M. J. Brown, G. J. Clarkson, G. G. Inglis, M. Shipman, Org. Lett. 2011, 13, 1686-1689.

Rapid Synthesis of 1,3,4,4-Tetrasubstituted β-Lactams from Methyleneaziridines Using a Four-Component Reaction
C.C.A. Cariou, G.J. Clarkson, M. Shipman, J. Org. Chem. 2008, 73, 9762-9764.