Dr Manuela Tosin

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Dr Manuela Tosin

Laurea in Chemistry (cum laude), University of Padova (Italy); PhD, University College Dublin (Ireland); MRSC.

Assistant Professor of Organic Chemistry 

Research Summary

Development of chemical probes/tools aiming at (i) uncovering the details of complex mechanisms involved in natural product biosynthesis; (ii) generating novel natural products of improved pharmacological activity; (iii) exploring new sources of natural products.
Selected Publications

Insights into Lasalocid A Ring Formation by Chemical Chain Termination in vivo. M. Tosin*, L. Smith, P. F. Leadlay. Angew. Chem. Int. Ed. 2011, 50, 11930-11933.

In vivo Trapping of Polyketide Intermediates from an Assembly Line Synthase using Malonyl-Carba(dethia)-N-Acetyl Cysteamines. M. Tosin*, Y. Demdychuk, J. S. Parascandolo, C. Blasco Per, F. J. Leeper, P. F. Leadlay. ChemComm 2011, 47, 3460-3462.

Synthetic Chain Terminators Off-Load Intermediates from a Type I Polyketide Synthase. M. Tosin*, L. Betancor, E. Stephens, W. M. A. Li, J. B. Spencer, P. F. Leadlay. ChemBioChem 2010, 11, 539-546.

Insights into Protein-Protein and Enzyme-Substrate Interactions in Modular Polyketide Synthases. L. Tran, R. W. Broadhurst, M. Tosin, A. Cavalli, K. J. Weissman. Chem. Biol. 2010, 17, 705-716.

In vitro Reconstruction of Tetronate RK-682 Biosynthesis. Y. Sun, F. Hahn, Y. Demdychuk, J. Chettle, M. Tosin, H. Osada, P. F. Leadlay. Nature Chem. Biol. 2010, 6, 99-101.

Malonyl carba(dethia)- and Malonyl oxa(dethia)-Coenzyme A as Tools for Trapping Polyketide Intermediates. M. Tosin*, D. Spiteller, J. B. Spencer. ChemBioChem 2009, 10, 1714-1723.