Recent results in the area of asymmetric catalysis using organometallic catalysts, particularly for asymmetric transfer hydrogenation of ketones and imines. We study the versatility and the kinetics of the reactions, and are always seeking new applications.

For examples of applications of the tethered complexes by other academic groups see:

Su, Y.; Tu, Y-Q.; Gu, P. Org. Lett. 2014, 16, 4204-4207. An application to the synthesis of gamma-lactones via reduction of an in situ-generated ketone.

Mangion, I. K.; Cheng-yi Chen, C.-y.; Li, H.; Maligres, P.; Chen, Y.; Christensen, M.; Cohen, R.; Jeon, I.; Klapars, A.;
Krska, S.; Nguyen, H.; Reamer, R. A.; Sherry, B. D.; Zavialov, I. Org. Lett., 2014, 16, 2310–2313. An application to reduction of a C=NH bond leading to a pharmaceutical target molecule.

For our work see the publications list for the references and more information. Selected examples are shown.

ref 124

ref 122

ref 120

ref115

ref 114

reference 78

reference 82

reference 92

reference 103

reference 97.

reference 80

reference 98

reference 94

references 46 and 71