Latest Journal Publications
A clinical trial comparing parenteral oxytetracyline and enrofloxacin on time to recovery in sheep lame with acute or chronic footrot in Kashmir, IndiaJ Kaler, SA Wani, I Hussain, SA Beg, M Makhdoomi, ZA Kabli and LE Green Title: A clinical trial comparing parenteral oxytetracyline and enrofloxacin on time to recovery in sheep lame with acute or chronic footrot in Kashmir, India TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transitionHills CE, Siamantouras E, Smith SW, Cockwell P, Liu KK, Squires PE. Diabetologia. 2012 Jan 4. [Epub ahead of print] Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic isletsGary K Yang, Paul E Squires, Faming Tian, Timothy J Kieffer, Yin Nam Kwok, Nicholas Dale
Islets 2012, 4 (1) [Epub ahead of print] http://www.landesbioscience.com/journals/islets/article/19037/ A new broccoli × broccoli immortal mapping population and framework genetic map: tools for breeders and complex trait analysis.
The authors present a new broccoli x broccoli mapping population with a B. oleracea L. var. italica ‘intra-crop’ specific framework linkage map which offers a unique tool for broccoli research since previously published B. oleracea maps have been constructed using diverse crosses between morphotypes of B. oleracea. Quantitative trait loci for agronomically important broccoli traits were mapped using these resources. This population and associated linkage map will aid breeders to directly map agronomically important traits for the improvement of elite broccoli cultivars.
Locus-specific view of flax domestication historyFu Y-B, Diederichsen A, Allaby RG Fu, Diederichsen and Allaby establish that flax had multiple origins and that the stearoyl-acyl carrier protein desaturase locus was a likely focus of selection in all domestication pathways. Interestingly, the results suggest that selection for oil quality came before loss of shattering, similar to the case of grain size and shattering in cereals. TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition.
In this article we provide compelling evidence that TGF-β1-induced epithelial-to-mesenchymal transition (EMT) instigates a loss of E-cadherin mediated cell adhesion and ultimately of connexin led cell-to-cell communication in the proximal tubule under diabetic conditions; these changes occur ahead of overt signs of renal damage. Diabetologia. 2012 Jan 4. [Epub ahead of print] |
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Efforts to treat diabetes and its associated symptoms have focused on examining how pancreatic secretions are regulated and how they become disrupted in disease. One possible regulator is adenosine, a small molecule released by many parts of the body with multiple potent actions. In this paper, Prof Dale and his colleagues describe how novel enzyme-coated electrode biosensors were used to measure adenosine levels in cells of rodent pancreata to better understand the physiological significance of this mechanism in regulating pancreatic secretions.
Hills CE
