Professor Christopher Dowson
Professor of Microbiology
Email: C.G.Dowson@warwick.ac.uk
Phone: 024 765 23534
Office: IBRB2.24
Dowson webpage
Research Clusters
Warwick Centres and GRPs
Health GRP (AMR theme co-lead)
Warwick Antimicrobial Interdisciplinary Centre (WAMIC)
Warwick Antimicrobial Screening Facility
Sir Howard Dalton Centre for Translational Mechanistic Enzymology (Co-Director)
Vacancies and Opportunities
For postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.
Research Interests
Professor Chris G Dowson has, for many years, examined the emergence and evolution of antibiotic resistance across a wide range of bacteria. His recent focus has been to better understand how penicillin targets bacteria. This began during his postdoctoral time at the University of Sussex, in the laboratory of Professor Spratt (1986-1990) and subsequently with his Lister Institute Centenary Fellowship (1991-1996). He currently holds a personal chair at Warwick University and is a past member of the Medical Research Council Infections and Immunity Board. He has established the Sir Howard Dalton Centre HDC for Translational Mechanistic Enzymology, the Warwick Antimicrobial Interdisciplinary Centre WAMIC, location of the Medicines Discovery Catapult MDC Laboratory facility at Warwick and has been involved with philanthropic research fundraising regionally across Warwickshire for the past 16 years with the Medical and Life Sciences Research Fund MLSRF and the national antibiotic discovery charity Antibiotic Research UK ANTRUK.
Chris' research has been funded by BBSRC, EPSRC, MRC, NIH, Wellcome Trust, smaller charities and industry. It is highly collaborative, involving teams of biologists, chemists, engineers and physicists across universities in the UK SWON Alliance CA, CHN Accelerate CHUNK US, SA H3D, EU, AUS to help drive innovations from this research forward to a commercial outcome, which includes the development and use of high throughput biochemical assays and structural determination using the XChem platform at Diamond Light source and virtual reality to visualise antibiotic: target protein interactions. Industry partners past and present include AstraZeneca, Basilea, BicycleTx, Cubist, LifeArc, Merck, Novartis, Novobiotic, GSK and supported recently in AMR SME engagement with the Medicines Discovery Catapult MDC at Warwick and currently the Antimicrobial Screening Facility at Warwick. He is currently engaged in the open source antibiotics discovery program and helping to develop and influence global AMR discovery policy and training for the next generation of AMR leaders. This has leapt forward with a £1.5M donation from the GB Sasakawa Foundation to drive UK-Japan collaboration to tackle AMR. This award will support two policy fellows, one from UKHSA the 'Dame Sally Davies Fellowship' and another NCGM, Tokyo the 'Mr Yasuhisa Shinozaki Fellowship' plus four science programs arising from the GBSF/HDC Tokyo workshop March 2024
Research: Technical Summary
The development of new reagents and new assays are crucial underpinning technologies enabling a multi-target focus to antibiotic discovery, with priorities in peptidoglycan biosynthesis and protein biosynthesis (aminoacyl tRNA synthetases, aaRS). The focus of my research is peptidoglycan biosynthesis as an enduringly attractive target or antibiotic discovery, including the multi-targeting of penicillin-binding proteins and Mur ligases.
I am a Co-Director of the Sir Howard Dalton Centre for Translational Mechanistic Enzymology. The Centre brings takes an interdisciplinary approach to drive innovative solutions for antimicrobial discovery, and build research and training capacity to address the global challenge of antimicrobial resistance:
- Enzymology: Protein production, substrate synthesis, kinetic characterisation, developing probe compounds, assay development, High-throughput screening and inhibitor discovery
- Structural Biology: X-Ray Crystallography, NMR, High Resolution Imaging (Electron Microscopy, Cryo-Electron Microscopy, Light Microscopy
- Computational Modelling: Systems modelling and structure-based modelling to develop mechanistic insights
- Professor in Microbiology, Warwick University 2000-
- Reader in Microbiology, Warwick University 1996-1999
- Lister Institute (Centenary) Research Fellow, Sussex University 1991-1996
- Postdoctoral Research Fellow, Sussex University 1986- 1990
- PhD Microbiology, Bath University 1987
- BSc (hons) Applied Biology, Bath University 1982
- Stefanini, Irene, Stoakes, Emily, Wu, Houdini H. T., Xu-McCrae, Li, Hussain, Abid, Moat, John, Dowson, Christopher G., David, Miruna D., Constantinidou, Chrystala, 2022. Genomic assembly of clinical Candida glabrata (Nakaseomyces glabrata) isolates reveals within-species structural plasticity and association with In Vitro antifungal susceptibility. Microbiology Spectrum, 10 (6)
- Dowson, Amanda J., Lloyd, Adrian J., Cuming, Andrew C., Roper, David I., Frigerio, Lorenzo, Dowson, Christopher G., 2022. Plant peptidoglycan precursor biosynthesis : conservation between moss chloroplasts and Gram-negative bacteria. Plant Physiology, 190 (1), pp. 165-179
- Newman, Hector, Krajnc, Alen, Bellini, Dom, Eyermann, Charles J., Boyle, Grant A., Paterson, Neil G., McAuley, Katherine E., Lesniak, Robert, Gangar, Mukesh, von Delft, Frank, Brem, Jürgen, Chibale, Kelly, Schofield, Christopher J., Dowson, Christopher G., 2021. High-throughput crystallography reveals boron-containing inhibitors of a Penicillin-binding protein with di- and tricovalent binding modes. Journal of Medicinal Chemistry, 64 (15), pp. 11379-11394
- Tran, Wendy, Kusay, Ali S., Hawkins, Paige M. E., Cheung, Chen-Yi, Nagalingam, Gayathri, Pujari, Venugopal, Ford, Daniel J., Stoye, Alexander, Ochoa, Jessica L., Audette, Rebecca E., Hortle, Elinor, Oehlers, Stefan H., Charman, Susan A., Linington, Roger G., Rubin, Eric J., Dowson, Christopher G., Roper, David I., Crick, Dean C., Balle, Thomas, Cook, Gregory M. et al (Select to open full list), 2021. Synthetic sansanmycin analogues as potent mycobacterium tuberculosis translocase I inhibitors. Journal of Medicinal Chemistry, 64 (23), pp. 17326-17345
- Klug, Dana M., Idiris, Fahima I. M., Blaskovich, Mark A. T., von Delft, Frank, Dowson, Christopher G., Kirchhelle, Claas, Roberts, Adam P., Singer, Andrew C., Todd, Matthew H., 2021. There is no market for new antibiotics : this allows an open approach to research and development. Wellcome Open Research, 6
- Cama, J., Leszczynski, R., Tang, P. K., Khalid, A., Lok, V., Dowson, Christopher G., Ebata, A., 2021. To push or to pull? In a post-COVID world, supporting and incentivizing antimicrobial drug development must become a governmental priority. ACS Infectious Diseases, 7 (8), pp. 2029-2042
- Aggarwal, Surya D., Lloyd, Adrian J., Yerneni, Saigopalakrishna S., Narciso, Ana Rita, Shepherd, Jennifer, Roper, David I., Dowson, Christopher G., Filipe, Sergio R, Hiller, N Luisa, 2021. A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in Streptococcus pneumoniae. Proceedings of the National Academy of Sciences of the United States of America, 118 (14)
- York, Anna, Lloyd, Adrian J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen, Fritz, Konstantin, Fülöp, Vilmos, Dowson, Christopher G., Khalid, Syma, Roper, David I., 2021. Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane. Structure, 29 (7), pp. 731-742
- Kidd, Sarah L., Fowler, Elaine, Reinhardt, Till, Compton, Thomas, Mateu, Natalia, Newman, Hector, Bellini, Dom, Talon, Romain, McLoughlin, Joseph, Krojer, Tobias, Aimon, Anthony, Bradley, Anthony, Fairhead, Michael, Brear, Paul, Díaz-Sáez, Laura, McAuley, Katherine, Sore, Hannah F., Madin, Andrew, O'Donovan, Daniel H., Huber, Kilian V. M. et al (Select to open full list), 2020. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical Science, 11 (39), pp. 10792-10801
- Styles, Kathryn, Thummeepak, Rapee, Leungtongkam, Udomluk, Smith, Sophie, Christie, Gabrielle S., Millard, Andrew D., Moat, John, Dowson, Christopher G., Wellington, Elizabeth M. H., Sitthisak, Sutthirat, Sagona, Antonia P., 2020. Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii. Antibiotics, 9 (4)
- Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I., Dowson, Christopher G., 2020. Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11), pp. 5034-5048
- Jacques, Laura C., Panagiotou, Stavros, Baltazar, Murielle, Senghore, Madikay, Khandaker, Shadia, Xu, Rong, Bricio-Moreno, Laura, Yang, Marie, Dowson, Christopher G., Everett, Dean B., Neill, Daniel R., Kadioglu, Aras, 2020. Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. Nature Communications, 11 (1)
- Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, Calvopiña, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J., Brem, Jürgen, 2019. Profiling interactions of vaborbactam with metallo-ß-lactamases. Bioorganic & Medicinal Chemistry Letters, 29 (15), pp. 1981-1984
- Massarweh, Ahmad, Bosco, Michael, Chantret, Isabelle, Léger, Thibaut, Jamal, Layla, Roper, David I., Dowson, Christopher G., Busca, Patricia, Bouhss, Ahmed, Gravier-Pelletier, Christine, Moore, Stuart E. H., 2019. Bacterial lipid II analogs : novel in vitro substrates for mammalian oligosaccharyl diphosphodolichol diphosphatase (DLODP) activities. Molecules, 24 (11)
- Bellini, Dom, Koekemoer, Lizbé, Newman, Hector, Dowson, Christopher G., 2019. Novel and improved crystal structures of H. influenzae, E. coli and P. aeruginosa penicillin-binding protein 3 (PBP3) and N. gonorrhoeae PBP2 : toward a better understanding of ß-Lactam target-mediated resistance. Journal of Molecular Biology, 431 (18), pp. 3501-3519
- Cain, Ricky, Salimraj, Ramya, Punekar, Avinash S., Bellini, Dom, Fishwick, Colin W. G., Czaplewski, Lloyd, Scott, David J., Harris, Gemma, Dowson, Christopher G., Lloyd, Adrian J., Roper, David I., 2019. Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase. Journal of Medicinal Chemistry, 62 (21), pp. 9703-9717
- Hind, Charlotte K., Dowson, Christopher G., Sutton, J. Mark, Jackson, Thomas, Clifford, Melanie, Garner, R. Colin, Czaplewski, Lloyd, 2019. Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens. Antimicrobial Agents and Chemotherapy, 63
- Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P., Aimon, Anthony, Amitai, Gabriel, Bellini, Dom, Bennett, James, Fairhead, Michael, Fedorov, Oleg, Gabizon, Ronen, Gan, Jin, Guo, Jingxu, Plotnikov, Alexander, Reznik, Nava, Ruda, Gian Filippo, Díaz-Sáez, Laura et al (Select to open full list), 2019. Rapid covalent-probe discovery by electrophile-fragment screening. Journal of the American Chemical Society, 141 (22), pp. 8951-8968
- Hu, Qingfeng, Yu, Yan, Gu, Dongshi, Xie, Li, Chen, Xingrou, Xu, Ning, Ruan, Jennifer Jin, Dowson, Christopher G., Ruan, Benfang Helen, 2019. Precise Measurement of Time Dependent Cell Growth and Detection of Partial Drug Resistance in Infectious Microbial. ACS Infectious Diseases, 5 (7), pp. 1252-1263
- Hrast, Martina, Jukic, Marko, Patin, Delphine, Tod, Julie, Dowson, Christopher G., Roper, David I., Barreteau, Hélène, Gobec, Stanislav, 2018. In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB. Chemical Biology & Drug Design, 91 (6), pp. 1101-1112
- Punekar, Avinash S., Samsudin, Firdaus, Lloyd, Adrian J., Dowson, Christopher G., Scott, David J., Khalid, Syma, Roper, David I., 2018. The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization. The Cell Surface, 2, pp. 54-66
- Ratamero, Erick Martins, Bellini, Dom, Dowson, Christopher G., Römer, Rudolf A., 2018. Touching proteins with virtual bare hands : visualizing protein?drug complexes and their dynamics in self-made virtual reality usinggaming hardware. Journal of Computer-Aided Molecular Design, 32 (6), pp. 703-709
- Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G., Lewandowski, Józef R., 2018. Structural studies suggest aggregation as one of the modes of action for teixobactin. Chemical Science, 9 (47), pp. 8850-8859
- Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian J., Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G., Sadler, P. J., 2018. Biguanide iridium(III) complexes with potent antimicrobial activity. Journal of Medicinal Chemistry, 61 (16), pp. 7330-7344
- Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, Ko?mrlj, Janez, Dowson, Christopher G., 2017. Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127, pp. 223-234
- Sychantha, David, Jones, Carys S., Little, Dustin J., Moynihan, Patrick J., Robinson, Howard, Galley, Nicola F., Roper, David I., Dowson, Christopher G., Howell, P. Lynne, Clarke, Anthony J., 2017. In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). PLOS Pathogens, 13 (10)
- Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, Fülöp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S., Roper, David I., 2017. Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1)
- Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata, Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J., 2017. Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8
- Kuroki, Agnès, Sangwan, Parveen, Qu, Yue, Peltier, Raoul, Sanchez-Cano, Carlos, Moat, John, Dowson, Christopher G., Williams, Elizabeth G. L., Locock, Katherine E. S., Hartlieb, Matthias, Perrier, Sébastien, 2017. Sequence control as a powerful tool for improving the selectivity of antimicrobial polymers. ACS Applied Materials & Interfaces, 9 (46), pp. 40117-40126
- Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng-Ruh, Linington, Roger G., Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J., 2017. Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.. Nature Communications, 8
- Dowson, Christopher G., O'Reilly, Steven, 2016. DNA methylation in fibrosis. European Journal of Cell Biology, 95 (9), pp. 323-330
- Araújo, Carlos Leonardo de A., Dias, Larissa M., Veras, Adonney A. O., Alves, Jorianne T. C., Cavalcante, Ana Lídia Q., Dowson, Christopher G., Azevedo, Vasco, Ramos, Rommel T. J., Silva, Artur, Carneiro, Adriana R., 2016. Whole-genome sequence of Corynebacterium pseudotuberculosis 262 biovar equi isolated from cow milk. Genome Announcements, 4 (2)
- Nelson, E Andrea, Wright-Hughes, Alexandra, Brown, Sarah, Lipsky, Benjamin A, Backhouse, Michael, Bhogal, Moninder, Ndosi, Mwidimi, Reynolds, Catherine, Sykes, Gill, Dowson, Christopher G., Edmonds, Michael, Vowden, Peter, Jude, Edward B., Dickie, Tom, Nixon, Jane, 2016. Concordance in diabetic foot ulceration : a cross-sectional study of agreement between wound swabbing and tissue sampling in infected ulcers. Health Technology Assessment, 20 (82)
- Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G., Sadler, P. J., 2016. Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1), pp. 395-404
- Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A., Besra, Gurdyal S., 2016. Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6
- Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh et al (Select to open full list), 2015. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6, pp. 1-11
- Rushton, Laura, Sass, Andrea, Baldwin, Adam, Dowson, Christopher G., Donoghue, Denise, Mahenthiralingam, Eshwar, 2013. Key role for efflux in the preservative susceptibility and adaptive resistance of burkholderia cepacia complex bacteria. Antimicrobial Agents and Chemotherapy, 57 (7), pp. 2972-2980
- Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I., Dowson, Christopher G., 2013. Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. ACS Chemical Biology, 8 (10), pp. 2157-2163
- Dobrzanska, Dorota A., Cooper, A. (Amy), Dowson, Christopher G., Evans, Stephen D., Fox, David J., Johnson, Benjamin R., Biggs, Caroline I., Randev, Rajan, Stec, Helena M., Taylor, Paul C., Marsh, Andrew, 2013. Oxidation of tertiary amine-derivatized surfaces to control protein adhesion. Langmuir, 29 (9), pp. 2961-2970
- Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I., Dowson, Christopher G., 2013. Adenosine Tetraphosphoadenosine drives a continuous ATP-release assay for Aminoacyl-tRNA synthetases and other Adenylate-forming enzymes. ACS Chemical Biology, 8 (10), pp. 2157-2163
- Castro, Thiago L. P., Seyffert, Nubia, Ramos, Rommel T. J., Barbosa, Silvanira, Carvalho, Rodrigo D. O., Pinto, Anne Cybelle, Carneiro, Adriana Ribeiro, Silva, Wanderson Marques, Pacheco, Luis G. C., Downson, Christopher G., Schneider, Maria P. C., Miyoshi, Anderson, Azevedo, V. (Vasco), Silva, Artur, 2013. Ion torrent-based transcriptional assessment of a Corynebacterium pseudotuberculosis equi strain reveals denaturing high-performance liquid chromatography a promising rRNA depletion method. Microbial Biotechnology, 6 (2), pp. 168-177
- Ruane, Karen M., Lloyd, Adrian J., Fülöp, Vilmos, Dowson, Christopher G., Barreteau, Hélène, Boniface, Audrey, Dementin, Sébastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Gobec, Stanislav, Dessen, Andréa, Roper, David I., 2013. Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. Journal of Biological Chemistry, 288 (46)
- Dobrzanska, Dorota A., Cooper, Amy L., Dowson, Christopher G., Evans, Stephen D., Haynes, Tommy, Johnson, Benjamin R. G., Stec, Helena M., Taylor, Paul C., Marsh, Andrew, 2012. Protein-adhesive and protein-resistant functionalized silicon surfaces. Langmuir
- Hassan, S. S., Schneider, M. P. C., Ramos, R. T. J., Carneiro, A. R., Ranieri, A., Guimaraes, L. C., Ali, A., Bakhtiar, S. M., Pereira, U. d. P., dos Santos, A. R., Soares, S. d. C., Dorella, F., Pinto, A. C., Ribeiro, D., Barbosa, M. S., Almeida, S., Abreu, V., Aburjaile, F., Fiaux, K., Barbosa, E. et al (Select to open full list), 2012. Whole-Genome Sequence of Corynebacterium pseudotuberculosis Strain Cp162, Isolated from Camel. Journal of Bacteriology, Vol. 194 (No. 20), pp. 5718-5719
- Viguetti, S. Z., Pacheco, L. G. C., Santos, L. S., Soares, S. C., Bolt, F., Baldwin, Adam, Dowson, Christopher G., Rosso, M. L., Guiso, N., Miyoshi, A., Hirata, R., Mattos-Guaraldi, A. L., Azevedo, V., 2012. Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil. Epidemiology and Infection, 140 (4), pp. 617-620
- Pacheco, Luis G. C., Castro, Thiago L. P., Carvalho, Rodrigo D. O., Moraes, Pablo M., Dorella, Fernanda A., Carvalho, Natália B., Slade, Susan E., Scrivens, James H., Feelisch, Martin, Meyer, Roberto, Miyoshi, Anderson, Oliveira, Sérgio C., Dowson, Christopher G., Azevedo, Vasco, 2012. A role for sigma factor sE in corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress. Frontiers in Microbiology, 3
- McDowell, A. (Andrew), Gao, Anna, Barnard, E. (Emma), Fink, Colin, Murray, Philip I., Dowson, Christopher G., Nagy, I. (István), Lambert, Peter A., Patrick, Sheila, 2011. A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens. Microbiology, Vol.157 (No.7), pp. 1990-2003
- Pacheco, Luis G. C., Slade, Susan E., Seyffert, Núbia, Santos, Anderson R., Castro, Thiago L. P., Silva, Wanderson M., Santos, Agenor V., Santos, Simone G., Farias, Luiz M., Carvalho, Maria A. R., Pimenta, Adriano M. C., Meyer, Roberto, Silva, Artur, Scrivens, James H., Oliveira, Sérgio C., Miyoshi, Anderson, Dowson, Christopher G., Azevedo, Vasco, 2011. A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis. BMC Microbiology, Vol.11
- Hattersley, John G., Pérez-Velázquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim, Evans, Neil D., 2011. Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2), pp. 70-80
- Bugg, Tim, Braddick, Darren, Dowson, Christopher G., Roper, David I., 2011. Bacterial cell wall assembly : still an attractive antibacterial target. Trends in Biotechnology, Vol.29 (No.4), pp. 167-173
- Drevinek, Pavel, Baldwin, Adam, Lindenburg, Laurens, Joshi, Lovleen Tina, Marchbank, Angela, Vosahlikova, Sarka, Dowson, Christopher G., Mahenthiralingam, Eshwar, 2010. Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping. Journal of Clinical Microbiology, Vol.48 (No.1), pp. 34-40
- Hall, Aron J., Cassiday, Pamela K., Bernard, Kathryn A., Bolt, Frances, Steigerwalt, Arnold G., Bixler, Danae, Pawloski, Lucia C., Whitney, Anne M., Iwaki, M., Baldwin, Adam, Dowson, Christopher G., Komiya, Takako, Takahashi, Motohide, Hinrikson, Hans P., Tondella, Maria L., 2010. Novel Corynebacterium diphtheriae in domestic cats. Emerging Infectious Diseases, Vol.16 (No.4)
- Bolt, Frances, Cassiday, Pamela, Tondella, Maria Lucia, DeZoysa, Aruni, Efstratiou, Androulla, Sing, Andreas, Zasada, Aleksandra, Bernard, Kathryn, Guiso, Nicole, Badell, Edgar, Rosso, Marie-Laure, Baldwin, Adam, Dowson, Christopher G., 2010. Multilocus sequence typing identifies evidence for recombination and two distinct lineages of corynebacterium diphtheriae. Journal of Clinical Microbiology, Vol.48 (No.11), pp. 4177-4185
- Aaron, Shawn D., Vandemheen, Katherine L., Ramotar, Karam, Giesbrecht-Lewis, Tracy, Tullis, Elizabeth, Freitag, Andreas, Paterson, Nigel, Jackson, Mary, Lougheed, M. Diane, Dowson, Christopher G., Kumar, Vijay, Ferris, Wendy, Chan, Francis, Doucette, Steve, Fergusson, Dean, 2010. Infection with transmissible strains of pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. JAMA: The Journal of the American Medical Association, Vol.304 (No.19), pp. 2145-2153
- Clarke, Thomas B., Kawai, Fumihiro, Park, Sam-Yong, Tame, Jeremy R. H., Dowson, Christopher G., Roper, David I., 2009. Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4. Biochemistry, Vol.48 (No.12), pp. 2675-2683
- Waine, David J., Honeybourne, David, Smith, E. Grace, Whitehouse, Joanna L., Dowson, Christopher G., 2009. Cross-sectional and longitudinal multilocus sequence typing of Pseudomonas aeruginosa in cystic fibrosis sputum samples. Journal of Clinical Microbiology, Vol.47 (No.11), pp. 3444-3448
- Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G., Bugg, Tim, 2009. Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9), pp. 3443-3455
- Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim, Levesque, Roger C., 2009. Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2), pp. 263-272
- Ward, Philip N., Holden, Matthew T. G., Leigh, James A., Lennard, Nicola, Bignell, Alexandra, Barron, Andy, Clark, Louise, Quail, Michael A., Woodward, John, Barrell, Bart G., Egan, Sharon A., Field, Terence R., Maskell, Duncan, Kehoe, Michael, Dowson, Christopher G., Chanter, Neil, 2009. Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis. BMC Genomics, Vol.10
- Dumville, Jo C., Worthy, Gill, Bland, J. Martin, Cullum, Nicky, Dowson, Christopher G., Iglesias, Cynthia, Mitchell, Joanne L., Nelson, E. Andrea, Soares, Marta O., Torgerson, David J., 2009. Larval therapy for leg ulcers (VenUS II): randomised controlled trial. British Medical Journal, Vol.338
- Spilker, Theodore, Baldwin, Adam, Bumford, Amy, Dowson, Christopher G., Mahenthiralingam, Eshwar, LiPuma, John J., 2009. Expanded multilocus sequence typing for Burkholderia species. Journal of Clinical Microbiology, Vol.47 (No.8), pp. 2607-2610
- Rose, Helen, Baldwin, Adam, Dowson, Christopher G., Mahenthiralingam, Eshwar, 2009. Biocide susceptibility of the Burkholderia cepacia complex. Journal of Antimicrobial Chemotherapy, Vol.63 (No.3), pp. 502-510
- Vanlaere, Elke, Baldwin, Adam, Gevers, Dirk, Henry, Deborah, De Brandt, Evie, LiPuma, John J., Mahenthiralingam, Eshwar, Speert, David P., Dowson, Christopher G., Vandamme, Peter, 2009. Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp nov and Burkholderia lata sp nov.. International Journal of Systematic and Evolutionary Microbiology, Vol.59 (Part 1), pp. 102-111
- Baldwin, Adam, Loughlin, Michael, Dr., Caubilla-Barron, Juncal, Kucerova, Eva, Manning, Georgina, Dowson, Christopher G., Forsythe, S. J. (Steve J.), 2009. Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes. BMC Microbiology, Vol.9 (Article 223)
- Holden, Matthew T. G., Hauser, Heidi, Sanders, Mandy, Ngo, Thi Hoa, Cherevach, Inna, Cronin, Ann, Goodhead, Ian, Mungall, Karen, Quail, Michael A., Price, Claire, Rabbinowitsch, Ester, Sharp, Sarah, Croucher, Nicholas J., Chieu, Tran Bich, Mai, Nguyen Thi Hoang, Diep, To Song, Chinh, Nguyen Tran, Kehoe, Michael, Leigh, James A., Ward, Philip N. et al (Select to open full list), 2009. Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. PLOS One, Vol.4 (No.7)
- Vanlaere, Elke, LiPuma, John J., Baldwin, Adam, Henry, Deborah, De Brandt, Evie, Mahenthiralingam, Eshwar, Speert, David, Dowson, Christopher G., Vandamme, Peter, 2008. Burkholderia latens sp nov., Burkholderia diffusa sp nov., Burkholderia arboris sp nov., Burkholderia seminalis sp nov and Burkholderia metallica sp nov., novel species within the Burkholderia cepacia complex. International Journal of Systematic and Evolutionary Microbiology, Vol.58 (Part 7), pp. 1580-1590
- Drevinek, Pavel, Baldwin, Adam, Dowson, Christopher G., Mahenthiralingam, Eshwar, 2008. Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia. BMC Microbiology, Vol.8 (No.44)
- Baldwin, Adam, Mahenthiralingam, Eshwar, Drevinek, Pavel, Pope, Chris, Waine, David J., Henry, Deborah A., Speert, David P., Carter, Phil, Vandamme, Peter, LiPuma, John J., Dowson, Christopher G., 2008. Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing. Journal of Clinical Microbiology, Vol.46 (No.1), pp. 290-295
- Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I., Dowson, Christopher G., 2008. Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10), pp. 6402-6417
- Waine, David J., Honeybourne, David, Smith, E. Grace, Whitehouse, Joanna L., Dowson, Christopher G., 2008. Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa. Journal of Clinical Microbiology, Vol.46 (No.10), pp. 3491-3493
- Marttinen, Pekka, Baldwin, Adam, Hanage, William P., Dowson, Christopher G., Mahenthiralingam, Eshwar, 2008. Bayesian modeling of recombination events in bacterial populations. BMC Bioinformatics, Vol.9 (No.421)
- De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G., Bugg, Tim, 2008. Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50), pp. 34571-34579
- Moore, Lisa J., Gilbey, Andrea M., Dowson, Christopher G., Pridmore, Alison C., Dower, Steven K., Read, Robert C., 2007. Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics. Journal of Antimicrobial Chemotherapy, 59 (1), pp. 35-42
- Baldwin, Adam, Mahenthiralingam, Eshwar, Drevinek, Pavel, Vandamme, Peter, Govan, John R., Waine, David J., LiPuma, John J., Chiarini, Luigi, Dalmastri, Claudia, Henry, Deborah A., Speert, David P., Honeybourne, David, Maiden, Martin C. J., Dowson, Christopher G., 2007. Environmental Burkholderia cepacia complex isolates in human infections. Emerging Infectious Diseases, Vol.13 (No.3), pp. 458-461
- Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G., Weiser, Jeffrey N., 2007. Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PLoS Pathogens, Vol.3 (No.8), pp. 1073-1081
- Waine, David J., Henry, Deborah A., Baldwin, Adam, Speert, David P., Honeybourne, David, Mahenthiralingam, Eshwar, Dowson, Christopher G., 2007. Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis. Journal of Cystic Fibrosis, Vol.6 (No.3), pp. 215-219
- Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G., Bugg, Tim, 2007. Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16), pp. 4654-4656
- Dalmastri, Claudia, Baldwin, Adam, Tabacchioni, Silvia, Bevivino, Annamaria, Mahenthiralingam, Eshwar, Chiarini, Luigi, Dowson, Christopher G., 2007. Investigating Burkholderia cepacia complex populations recovered from Italian maize rhizosphere by multilocus sequence typing. Environmental Microbiology, Vol.9 (No.7), pp. 1632-1639
- Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G., Weiser, Jeffrey N., 2007. Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PL o S Pathogens, Vol.3 (No.8), pp. 1073-1081
- Tötemeyer, Sabine, Sheppard, Mark, Lloyd, Adrian, Roper, David I., Dowson, Christopher G., Underhill, David, Murray, Peter, Maskell, Duncan, Bryant, Clare, 2006. IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. Journal of Immunology, Vol.176 (No.8), pp. 4804-4810
- Mahenthiralingam, Eshwar, Baldwin, Adam, Drevinek, Pavel, Vanlaere, Elke, Vandamme, Peter, LiPuma, John J., Dowson, Christopher G., 2006. Multilocus sequence typing breathes life into a microbial metagenome. PLoS One, Vol.1 (No.1)
- 'Schouten, James A., 'Bagga, Sangeev, 'Lloyd, Adrian J., 'De Pascale, Gianfranco, 'Dowson, Christopher G., 'Roper, David I., 'Bugg, Timothy D. H., 2006. 'Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.. Molecular BioSystems, 2 (10), pp. 484-491
- Smith, Edward M., Green, Laura E., Medley, Graham, Bird, H. E., Fox, L. K., Schukken, Y. H., Kruze, J. V., Bradley, Andrew J., Zadoks, Ruth N., Dowson, Christopher G., 2005. Multilocus sequence typing of intercontinental bovine Staphylococcus aureus isolates. Journal of Clinical Microbiology, Vol.43 (No.9), pp. 4737-4743
- Dougan, Gordon, Dowson, Chris, Overington, John, 2019. Meeting the discovery challenge of drug-resistant infections : progress and focusing resources. Next Generation Antibiotic Discovery Symposium, Jan 2018, Published in Drug Discovery Today, pp. 452-461
- Bernard, K., Schindle, S., Burdz, T., Wiebe, D., Reimer, A., Dowson, Christopher G., Bolt, F., Baldwin, Adam, 2009. The use of a multi locus sequence typing scheme to characterize Canadian isolates of Corynebacterium diphtheriae. 26th International Congress of Chemotherapy and Infection, Toronto, Canada, June 18-21, 2009, Published in International Journal of Antimicrobial Agents, pp. S11-S11
- Bearup, Daniel James, Evans, Neil D., Dowson, Christopher G., Chappell, M. J. (Michael J.), 2009. Use of structural identifiability analysis to inform experimental design for enzyme kinetics. The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008, Published in 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book
- Gardner, J. W., Apostolidou, A., Cole, Marina, Dowson, Christopher G., Edmunds, S., Sehra, G., 2007. Towards a low-cost optical iriosensor system for biomedical immunoassay applications. 5th IASTED International Conference on Biomedical Engineering, Innsbruck, Austria, 14-16 Feb 2007, Published in Proceedings of the Fifth IASTED International Conference on Biomedical Engineering, pp. 277-282
- Yates, J. W. T., Gardner, J. W., Chappell, M. J. (Michael J.), Bolt, F., Beeby, L., Dowson, Christopher G., 2003. Chemical sensor screening of blood samples : robust analysis via data set reduction. 5th IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, 21-23 Aug 2003, Published in Modellling and Control in Biomedical Systems 2003 (including Biology Systems), pp. 289-294
- Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian, Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G., Sadler, P. J., 2018. Data for Biguanide iridium(III) complexes with potent antimicrobial activity. School of Chemistry, University of Warwick
- Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G., Lewandowski, Józef R., 2018. Data for Structural studies suggest aggregation as one of the modes of action for teixobactin. Department of Chemistry, University of Warwick
- Dumville, J. C., Worthy, G., Soares, M. O., Bland, J. M., Cullum, N., Dowson, Christopher G., Iglesias, C., McCaughan, D., Mitchell, J. L., Nelson, E. A., Torgerson, D. J., 2009. VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers. Health Technology Assessment
- Holden, Matthew T. G., Seth-Smith, Helena M. B., Crossman, Lisa C., Sebaihia, Mohammed, Bentley, Stephen D., Cerdeno-Tarraga, Ana M., Thomson, Nicholas R., Bason, Nathalie, Quail, Michael A., Sharp, Sarah, Cherevach, Inna, Churcher, Carol, Goodhead, Ian, Hauser, Heidi, Holroyd, Nancy, Mungall, Karen, Scott, P. D. (Paul D.), Walker, Danielle, White, Brian, Rose, Helen et al (Select to open full list), 2009. The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. Journal of Bacteriology, American Society for Microbiology, pp. 261-277
- Holden, Matthew T. G., Seth-Smith, Helena M. B., Crossman, Lisa C., Sebaihia, Mohammed, Bentley, Stephen D., Cerdeno-Tarraga, Ana M., Thomson, Nicholas R., Bason, Nathalie, Quail, Michael A., Sharp, Sarah, Cherevach, Inna, Churcher, Carol, Goodhead, Ian, Hauser, Heidi, Holroyd, Nancy, Mungall, Karen, Scott, P. D. (Paul D.), Walker, Danielle, White, Brian, Rose, Helen et al (Select to open full list), 2009. Author's correction to The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. Journal of Bacteriology, American Society for Microbiology, pp. 2907-2907
- Mahenthiralingam, Eshwar, Baldwin, A. (Adam), Dowson, Christopher G., 2008. Burkholderia cepacia complex bacteria : opportunistic pathogens with important natural biology. Journal of Applied Microbiology, Wiley-Blackwell Publishing Ltd, pp. 1539-1551
- Nelson, E. A., O'Meara, S., Craig, D, Iglesias, C., Golder, S, Dalton, J, Claxton, K, Bell-Syer, S.E.M., Jude, E, Dowson, Christopher G., Gadsby, Roger, O'Hare, J. Paul, Powell, John, 2006. A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers. Health Technology Assessment, NIHR Health Technology Assessment programme, pp. 1-+
- Gardner, J. W., Hines, E.L., Dowson, Christopher G., 2004. Smelling illness. Ingenia
Title | Funder | Award start | Award end |
---|---|---|---|
Antimicrobial Resistance: Breakthrough Compound Discovery through Mechanistic Studies combined with Bicycle Technology and Target Validation - BBSRC Prosperity Partnership Full Stage - March 2023 | BBSRC | 15 Nov 2023 | 14 Nov 2026 |
MEDICAL RESEARCH FOUNDATION NATIONAL PHD TRAINING PROGRAMME IN ANTIMICROBIAL RESISTANCE RESEARCH - A-code | Medical Research Foundation | 01 Oct 2017 | 30 Sep 2025 |
Healthcare Associated Infections and Antimicrobial Resistance at Imperial College | National Institute for Health Research (NIHR DoH) | 01 Apr 2020 | 31 Mar 2025 |
Enabling public and private partnership platforms to accelerate antibiotic discovery linked to 72691 | Rosalind Franklin Institute | 21 Jul 2022 | 20 Nov 2024 |
Sulbactam cefepime | ANTRUK Enterprises Limited | 02 Jan 2020 | 31 Mar 2024 |
Developing mechanistic understanding to improve the activity of bicyclic peptides as novel antimicrobials | MRC | 13 Sep 2021 | 12 Sep 2023 |
BBSRC Mid-range Equipment ALERT 2021 Application - November 2021 | BBSRC | 01 Aug 2022 | 31 Jul 2023 |
MRC UK China Hubs | MRC | 01 Jan 2019 | 31 Mar 2022 |
CoA: CHNUK: Integrated platforms from science to policy in response to antibacterial resistance; linked to Ideate 58956 | UK Research and Innovation | 01 Jul 2020 | 30 Sep 2021 |
CoA: [Mechanistic understanding of cell wall biosynthesis to combat antimicrobial resistance: Cell Wall AMR]; linked to Ideate 46475 | UK Research and Innovation | 01 Mar 2021 | 28 Aug 2021 |
Mechanistic understanding of cell wall biosynthesis to combat antimicrobial resistance: Cell Wall AMR | MRC | 01 Jul 2015 | 28 Aug 2021 |
19 Alert mid-range Equipment Initiative: equipment to upgrade the 600 NMR console at the NMR facility. | BBSRC | 01 Nov 2020 | 31 Mar 2021 |
Science City TM1 Clinical Trials (Warwick-led) - Inter Institutional Agreement | Advantage West Midlands | 01 Aug 2009 | 31 Jul 2019 |
Accelerate CHNUK AMR discovery: Establishing and exploiting a joint China/UK platform to enable high throughput fragment based inhibitor discovery | MRC | 01 Jul 2016 | 30 Jun 2019 |
Research Project on Penicillin (WCPRS) | Micropathology Limited | 05 Oct 2015 | 04 Apr 2019 |
Developing the next generation of beta-lactamase inhibitors and monobactum antibiotics - GCRF network grant | Academy of Medical Sciences | 28 Jan 2018 | 27 Jan 2019 |
Cell wall biosynthesis ? a structural and biochemical characterization of penicillin-binding-proteins Lister summer studentship for Anna Schorfield | Lister Institute of Preventive Medicine | 02 Jul 2018 | 07 Sep 2018 |
Multi-Targetting of tRNA synthetases: A paradigm shift in combating AMR | MRC | 01 Mar 2015 | 30 Nov 2017 |
Development of orally active analogs of Teixobactin | Gates Foundation | 08 Feb 2017 | 31 Oct 2017 |
Cell wall biosynthesis in Yersinia pestis ? a structural and biochemical characterization of penicillin-binding-proteins (Lister Summer Studentship for Rachel Evans) | Lister Institute of Preventive Medicine | 10 Jul 2017 | 01 Sep 2017 |
Enabling novel penicillin-binding-protein high throughput screens | Wellcome Trust | 01 Jul 2016 | 30 Jun 2017 |
International exploitation of new reagents and assays for antibiotic discovery | BBSRC | 03 May 2015 | 02 May 2016 |
FLIP: Enabling exploitation of novel reagents and assays (EnRgy) | BBSRC | 24 Feb 2014 | 23 Feb 2016 |
Development of assays and reagents in the final steps of peptidoglycan. | AstraZeneca Pharmaceuticals LP | 01 Oct 2013 | 31 Dec 2015 |
Team CanUK: Novel antibacterial targets, assays, probes and opportunities in bacterial cell wall biogenesis | MRC | 01 Jan 2012 | 31 Dec 2015 |
BBSRC Link with Astra Zeneca:Reagents and assays to exploit the final steps of peptidoglycan construction | BBSRC | 01 Aug 2013 | 31 Jul 2015 |
Optimisation of anaerobic digestion (process monitoring) | Guy and Wright Limited | 01 Feb 2010 | 30 Jun 2015 |
Support for Chris Dowson Research - Medical & Life Sciences Research Fund | Medical and Life Sciences Research Fund | 01 Dec 2013 | 31 Jul 2014 |
The biochemical characterisation of pivotal enzymes involved in mycobacterial peptidoglycan biosynthesis Birmingham-Warwick PG grant | MRC | 01 May 2011 | 30 Apr 2014 |
Concordance in Diabetic Foot Ulceration - CODIFI (lead: University of Leeds) | National Institute for Health Research (DoH) | 01 Apr 2011 | 30 Sep 2013 |
Unesco- loreal Visiting Fellowship for Vita Majce | UNESCO | 01 May 2012 | 30 Apr 2013 |
Inter-Institutional Agreement Science City TM2 Experimental Medicine (Birmingham-led) | Advantage West Midlands | 20 Jul 2009 | 31 Mar 2012 |
Match funding for Chris Dowson Micropathology donation | Higher Education Funding Council for England | 01 Feb 2010 | 31 Jan 2011 |
Funding for Medical Research Fund Arden Fellow - Adam Baldwin | Micropathology Limited | 01 Aug 2008 | 31 Oct 2010 |
Medical Research Fund Arden Fellowship - Support for Elli Pinnock | Micropathology Limited | 01 Oct 2009 | 17 Sep 2010 |
UKCan - BACWAN | MRC | 01 Aug 2009 | 30 Apr 2010 |
UK BACWAN 2 | University of Sheffield | 01 May 2008 | 30 Apr 2010 |
CASE STUDENTSHIP - Eleanor Pinnock | Micropathology Limited | 01 Oct 2006 | 30 Sep 2009 |
TIME EXTENSION ONLY - Indistinguishability Analysis for Model Discrimination in Systems Biology: A Feasibility Study Applied to Bacterial Peptidoglycan Biosynthesis | EPSRC | 01 May 2009 | 31 Jul 2009 |
Indistinguishability Analysis for Model Discrimination in Systems Biology: A Feasibility Study Applied to Bacterial Peptidoglycan Biosynthesis | EPSRC | 01 Apr 2007 | 31 Mar 2009 |
Indistinguishability Analysis for Model Discrimination in Systems Biology: A Feasibility Study Applied to Bacterial Peptidoglycan Biosynthesis | EPSRC | 01 Apr 2007 | 31 Mar 2009 |
Funding for Medical Research Fund Arden Fellow - Adam Baldwin | Micropathology Limited | 01 Nov 2008 | 31 Jan 2009 |
Purchase of Kinetic Spectrophotometer | Eveson Charitable Trust | 01 Feb 2008 | 31 Jan 2009 |
Comparative Virulence of Clinical, Industrial and Environmental Isolates of the Opportunistic pathogen Pseudomonas Auruginosa - SGM summer studentship | Society for General Microbiology | 21 Jul 2008 | 12 Sep 2008 |
Funding for Medical Research Fund Arden Fellow - Adam Baldwin | Micropathology Limited | 01 May 2008 | 31 Jul 2008 |
UK - BaCWAN: UK-Bacterial Cell Wall Assembly Network | MRC | 01 Apr 2006 | 31 Mar 2008 |
Exploration and Exploitation of the Enzymology of PBP Driven Peptidoglycan Biosynthesis to Discover Novel Non-beta Lactam Antibiotics | MRC | 01 Mar 2005 | 29 Feb 2008 |
Expanding global databases for CF pathogens burkholderia cepacia complex and pseudomonas aeruginosa in order to investigate emerging infections. | Cystic Fibrosis Trust | 01 Feb 2007 | 31 Jan 2008 |
MLST Characterisation of Burkholeria cepacia complex orgnaisms | Unilever | 26 Oct 2007 | 31 Dec 2007 |
Screening for 21st Century cell wall inhibitors active against hospital acquired bacterial infections | Medical Research Fund of Warwick | 01 Jun 2007 | 30 Nov 2007 |
Molecular Physiology and structural analysis of the innate immune system triggered by bacterial cell wall components | British Pharmacological Society | 01 Oct 2004 | 30 Sep 2007 |
CASE Studentship: Frances Bolt | Micropathology Limited | 01 Oct 2004 | 30 Sep 2007 |
Admin Support - Developing rapid diagnostic tools for the control of infectious disease | WPH Charitable Trust | 01 Oct 2004 | 30 Sep 2007 |
Students into work application - vacation studentship for Duncan Hope | Society for Applied Microbiology | 09 Jul 2007 | 14 Sep 2007 |
Burkholderia Cepacia Complex Isolates from Industrial Origins | Unilever UK Central Resources Limited | 01 Oct 2006 | 31 Jan 2007 |
Multi locus sequence typing, rapid identification, evoluction and gene flux within Burkholderia cepacia complex isolates. | Wellcome Trust | 03 Jan 2004 | 31 Dec 2006 |
Student Research Training Project | South Warwickshire General Hospitals NHS Trust | 07 Nov 2005 | 06 Nov 2006 |
Screening for 21st century cell wall inhibitors active against hospital acquired bacterial infections | Medical Research Fund of Warwick | 01 Jan 2006 | 30 Sep 2006 |
Purchase of Electronic Noses via MRF | Eveson Charitable Trust | 21 Oct 2005 | 20 Sep 2006 |
Undergraduate Vacation Bursary: Psuedomonas in Mushrooms; Pathogenicity Assessments. | British Society for Plant Pathology | 11 Jul 2006 | 04 Sep 2006 |
Bridging Award for Dr Sehra | Royal Commission for the Exhibition of 1851 | 01 Jun 2005 | 31 May 2006 |
Genetic Diversity and Gene Expression in Pseudomonas Aeruginosa - Barry Curran | Micropathology Limited | 01 Oct 2002 | 30 Sep 2005 |
Developing a multilocus sequence typing scheme to characterise the causative agent of acne, Propionibacterium acnes | Society for General Microbiology | 27 Jun 2005 | 19 Aug 2005 |
Contribution to BBSRC case award (Barry Curran)Genetic and Phenotypic Diversity of Pseudomonas Aeruginosa | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2003 | 31 Mar 2005 |
The Characterisation and Activities of Compylobacter Jejuni and Listeria Monocylogenes Bacteriophage - CASE Award - James Taylor | Biotek Limited | 02 Oct 2000 | 30 Sep 2003 |