Prof. David Evans

David Evans

CONTACT   

Life Sciences
Gibbet Hill Campus
The University of Warwick
Coventry
CV4 7AL 		Tel: +44(0)2476574183
Fax: +44(0)2476523701
Email: D.J.Evans@warwick.ac.uk
Positive-strand RNA virus research

 

RESEARCH PROFILE


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The positive-strand RNA viruses include a number of important human and veterinary pathogens including the enteroviruses, hepatitis C virus, foot and mouth disease virus, coronaviruses, caliciviruses (winter vomiting disease), dengue and yellow fever. We study fundamental aspects of the biology of representative viruses within this group, with the long-term goal of understanding their replication, life cycle and evolution. A better understanding of these characteristics will facilitate the development of novel therapeutic strategies to prevent or treat virus infection, as well as providing the essential insights into virus biology that will help our comprehension of future viral threats to human and animal health.

Our current research interest includes the attachment and entry mechanism of enteroviruses, the replication of poliovirus, the role of cis-acting replication elements in the life-cycle of hepatitis C virus, the role of RNA structure in virus replication and evolution, and the mechanism and consequences of recombination.

BACKGROUND


BSc. Microbiology, University of Dundee, 1984
DPhil. University of Sussex, 1987

External examiner Imperial College London MSc. Society for General Microbiology member since 1985
Journal of General Virology Editor '04-'09, Editorial Board '10 - present

CURRENT RESEARCH PROJECTS


  • Interplay of RNA structure, protein and miRNA binding in early replication events of hepatitis C virus, with Dr Andrew K Tuplin - Biological Sciences, Funded by: MRC, Project Start Date: 01/10/2011 Project End Date: 30/09/2014
  • Unravelling the impact of the mite varroa destructor on the interaction between the honeybee and its viruses, with Dr James C Bull - Biological Sciences Prof Nigel J Burroughs - Systems Biology Centre Dr Eugene V Ryabov - Warwick HRI Dr David Chandler - Warwick HRI Dr Yiguo Hong - Warwick HRI, Funded by: BBSRC, Project Start Date: 01/01/2011 Project End Date: 31/12/2013

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SELECTED PUBLICATIONS


  • Tuplin, A., et al.(2011) 'Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus' Nucleic Acids Research 39 (16), 7034 - 7048 (0305-1048) [article]
  • Moore, J., et al.(2011) 'Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies' Journal Of General Virology 92 156 - 161 (0022-1317) [article]
  • Leitch, E. C. M., Cabrerizo, M., Cardosa, J., Harvala, H., Ivanova, O. E., Kroes, A. C. M., Lukashev, A., Muir, P., Odoom, J., Roivainen, M., Susi, P., Trallero, G., Evans, D. J. and Simmonds, P.(2010) 'Evolutionary dynamics and temporal/geographical correlates of recombination in the human enterovirus echovirus types 9, 11, and 30' Journal Of Virology 84 (18), 9292 - 9300 (0022-538X)
  • Millard, A. D., Gierga, G., Clokie, M. R. J., Evans, D., Hess, W. R. and Scanlan, D. J.(2010) 'An antisense RNA in a lytic cyanophage links psbA with a gene encoding a homing endonuclease' The ISME Journal: multidisciplinary journal of microbial ecology 4 (9), 1121 - 1135 (1751-7362)
  • McWilliam Leitch, E. C., Bendig, J., Cabrerizo, M., Cardosa, J., Hyypiä, T., Ivanova, O. E., Kelly, A., Kroes, A. C. M., Lukashev, A., MacAdam, A., McMinn, P., Roivainen, M., Trallero, G., Evans, D. J. and Simmonds, P.(2009) 'Transmission networks and population turnover of echovirus 30' Journal Of Virology 83 (5), 2109 - 2118 (0022-538X)

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Update My Profile on the Warwick eRA Portal My Profile last updated: 26/03/2012