RESEARCH PROFILE

My group uses structural biology techniques, principally X-ray structural analysis, in combination with molecular biology and biochemical techniques.

Our research interests are in two areas
1: Antibiotic resistance mechanisms and bacterial cell wall biosynthesis and
2: Bioremediation and degradation of aromatic chemicals.


We also administer the UK Bacterial Cell Wall Biosynthesis Network (UK-BaCWAN) further details can be found at
www.warwick.ac.uk/go/BACWAN

CURRENT RESEARCH PROJECTS

• Team CanUK: Novel antibacterial targets, assays, probes and opportunities in bacterial cell wall biogenesis, with Professor Christopher G Dowson, Life Sciences, - - - - Prof Tim D Bugg - Chemistry Dr David I Roper - Life Sciences Dr Adrian J Lloyd - Biological Sciences, Funded by: MRC, Project Start Date: 01/10/2011 Project End Date: 30/09/2015
• The biochemical characterisation of pivotal enzymes involved in mycobacterial peptidoglycan biosynthesis Birmingham-Warwick PG grant, with - Professor Christopher G Dowson - Biological Sciences Dr Adrian J Lloyd - Biological Sciences, Funded by: University of Birmingham, Project Start Date: 01/01/2011 Project End Date: 31/12/2013
• Unesco-l oreal Visiting Fellowship for Vita Majce, with Professor Christopher G Dowson - Life Sciences Dr Adrian J Lloyd - Life Sciences, Funded by: UNESCO, Project Start Date: 01/05/2012 Project End Date: 30/04/2013
  
  

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SELECTED PUBLICATIONS

• Pacheco-Gómez, R., et al.(2011) 'The pH dependence of polymerization and bundling by the essential bacterial cytoskeltal protein FtsZ' PLoS One 6 (6), (1932-6203) [article]
• Bugg Timothy D. H.; Braddick Darren; Dowson Christopher G.; et al(2011) 'Bacterial cell wall assembly: still an attractive antibacterial target' Trends In Biotechnology 29 (4), 167 - 173 (0167-7799)
• Hattersley, J.G., et al.(2011) 'Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis' Computer Methods And Programs In Biomedicine 104 (2), 70 - 80 (0169-2607) [article]
• Batson, S.,Rea, D.,Fülöp, V. and Roper, D.I.(2010) 'Crystallization and preliminary X-ray analysis of a D-alanyl-D-alanine ligase (EcDdlB) from Escherichia coli.' Acta Crystallographica Section F 66 (4), 405 - 408 (1744-3091) [article]
• Kawai F, Clarke TB, Roper DI, Han GJ, Hwang KY, Unzai S, Obayashi E, Park SY, Tame JR.(2010) 'Crystal Structures of Penicillin-Binding Proteins 4 and 5 from Haemophilus influenzae' Journal Of Molecular Biology 396 (3), 634 - 645 (0022-2836)

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