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    • Dr Emma Anderson
    University of Warwick

    Dr Emma Anderson

    Emma Anderson

    CONTACT   


    Life Sciences
    University of Warwick
    Coventry
    CV4 7AL
    Tel: 76150578
    Fax: 02476523701
    Email: E.C.Anderson@warwick.ac.uk
    Viral Translation Mechanisms

     


    RESEARCH PROFILE


    Viruses do not encode their own protein synthesis machinery, but must hijack that of their host cell. Viral mRNAs are vastly outnumbered by cellular mRNAs and therefore many viruses have evolved novel mechanisms to preferentially recruit ribosomes. We are interested in the mechanisms by which retroviruses such as HIV are able to recruit ribosomes to their RNAs at the right time to make the proteins they need for new viral particles.

    Due to the compact nature of their genomes, many viruses encode several proteins from one mRNA. We are also interested in the mechanisms that viruses employ to direct translation of different proteins from one RNA molecule.

    Understanding of these novel translation mechanisms will not only open up new avenues for treatment of viral infection, but also shed light on cellular protein synthesis. Loss of control of cellular translation has been shown to contribute to diseases such as diabetes and cancer.


    RESEARCH GROUPS


    • Infectious Agents

    BACKGROUND


    After graduating from Oxford in 1997 with a first class degree in Biochemistry, I moved to Cambridge to study for my PhD under the supervision of Professor Richard Jackson. My work on the translation of human rhinovirus RNA was the beginning of my interest in translation mechanisms and viruses. In 2001 I moved to The Scripps Research Institute, La Jolla, USA to work as a postdoctoral fellow with Dr Stephen Mayfield on light-regulated translation in Chlamydomonas reinhardtii. I returned to Cambridge in 2004 to work with Professor Andrew Lever in the Department of Medicine on the regulation of translation of HIV-1. In 2007 I was appointed as an Assistant Professor in Virology at Warwick, where I have continued my interest in translation mechanisms of important viruses such as HIV and influenza.

    RESEARCH PROJECTS


    Click on the link below to view all research projects


    View all Research Projects


    SELECTED PUBLICATIONS


    • Wise, H.M., et al.(2011) 'Overlapping signals for translational regulation and packaging of influenza A virus segment 2' Nucleic Acids Research 39 (17), 7775 - 7790 (0305-1048) [article]
    • Wise, H. M., Foeglein, A., Sun, J., Dalton, R. M., Patel, S., Howard, W., Anderson, E. C., Barclay, W. S. and Digard, P.(2009) 'A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA' Journal Of Virology 83 (16), 8021 - 8031 (0022-538X)
    • Groom, H. C. T., Anderson, E. C. and Lever, A. M. L.(2009) 'Rev: beyond nuclear export' Journal Of General Virology 90 (6), 1303 - 1318 (0022-1317)
    • Groom, H. C. T., Anderson, E. C., Dangerfield, J. A., and Lever, A. M. L.(2009) 'Rev regulates translation of human immunodeficiency virus type 1 RNAs' Journal Of General Virology 90 (5), 1141 - 1147 (0022-1317)
    • Anderson E C, Hunt S L, Jackson R J(2007) 'Internal initiation of translation from the human rhinovirus-2 IRES requires the binding of Unr to two distinct sites on the 5' UTR' Journal Of General Virology 88 3043 - 3052 (0022-1317)

    View all Publications


    Update My Profile on the Warwick eRA Portal My Profile last updated: 17/04/2012

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    School of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry, CV4 7AL
    Email: life dot sciences at warwick dot ac dot uk Tel: +44 (0)24 765 74251 Fax: +44 (0)24 765 23568
    Warwick Crop Centre is located on our Wellesbourne campus.

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