Dr Eugene Ryabov

Eugene Ryabov

TITLE   

Research Fellow

CONTACT   

Life Sciences
Gibbet Hill Campus
University of Warwick
Coventry
CV4 7AL 		Tel: 024 765 72537
Email: Eugene.Ryabov@warwick.ac.uk

 

RESEARCH PROFILE


Bee virus

Viruses are intracellular pathogens which utilize protein synthesis machinery and other systems of host cells for replication and spread. In order to withstand virus infections, their hosts have developed antivirus defenses including innate and adaptive immune responses and RNA interference (RNAi). Viruses have evolved a variety of counter-defense strategies to withstand these responses. Viruses greatly affect physiology, development and evolution of their hosts, and therefore have a wide medical, ecological and social impact.

We are interested in the factors affecting virus-host interactions in insects and plants, including virus diversity, mechanisms of antivirus responses (innate immunity signaling pathways and RNAi). Our current BBSRC-funded project explores the effect of the mite, Varroa destructor, on the interaction between the honeybee (Apis mellifera) and its viruses. It includes the study of genetic variation of antivirus responses in the honeybee and the effect on virus diversity on the pathogenesis.

See BBSRC Insect Pollinators Initiative and the David Evans Research Group

BACKGROUND


I began my research in Molecular Virology at Moscow State University (MSc,1991) and completed my PhD degree in Moscow in 1995. I then joined the Scottish Crop Research Institute (Dundee) to work on RNA movement functions of plant viruses. I then moved to HRI and subsequently University of Warwick. My research expanded to include plant antiviral defenses, in particular RNA silencing, and viral counter-defenses. In 2006, I then began my work on insect-virus interactions. This research focused on viruses of aphids and the honeybee, mechanisms of the antiviral responses, and the impact of viruses on the host physiology and development.

CURRENT RESEARCH PROJECTS


  • Unravelling the impact of the mite varroa destructor on the interaction between the honeybee and its viruses, with Professor David J Evans, Life Sciences, Dr James C Bull - Biological Sciences Prof Nigel J Burroughs - Systems Biology Centre Dr Eugene V Ryabov - Warwick HRI Dr David Chandler - Warwick HRI Dr Yiguo Hong - Warwick HRI, Funded by: BBSRC, Project Start Date: 01/01/2011 Project End Date: 31/12/2013

    View all Research Projects

SELECTED PUBLICATIONS


  • Ryabov, E.V.,Taliansky, M.E., Robinson, D.J., Waterhouse, P.M., Murant, A.F., de Zoeten, G.A., Falk, B.W., Vetten, H.J. & Gibbs, M.J., (2011) 'Genus Umbravirus' in Virus Taxonomy. Ninth Report of the International Committee on Taxonomy of Viruses., 1191 - 1195, Editors: King, A.M.Q., Adams, M.J., Carstens, E., Lefkowitz, E.J. (978-0-12-384684-6), Elsevier
  • Ryabov, E.V. & Evans, D.J.(2011) 'The plight of the honeybee' Microbiology Today 38 218 - 221 (1464-0570)
  • Moore, J., Jironkin, A., Chandler, D., Burroughs, N., Evans, D.J. and Ryabov, E.(2011) 'Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies' Journal Of General Virology 92 156 - 161 (0022-1317) [article]
  • Ryabov, E. V., Keane, G., Naish, N., Evered, C. and Winstanley, D. (2009) 'Densovirus induces winged morphs in asexual clones of the rosy apple aphid, Dysaphis plantaginea' Proceedings Of The National Academy Of Sciences (USA) 106 (21), 8465 - 8470 (0027-8424) [article]
  • Shi, Y., Ryabov, E. V., Van Wezel, R., Li, C., Jin, M., Wang, W., Fan, Z. and Hong, Y.(2009) 'Suppression of local RNA silencing is not sufficient to promote cell-to-cell movement of Turnip crinkle virus in Nicotiana benthamiana.' Plant Signaling and Behavior 4 (1), 15 - 22 (1559-2316)

View all Publications

Update My Profile on the Warwick eRA Portal My Profile last updated: 13/01/2012