Prof. Georgy Koentges
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TITLELaboratory of Genomic Systems Biology and Evolution CONTACT
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RESEARCH PROFILEMAIN INTERESTS:
1.Evo/Devo, relationship between development and evolution and systems biology see here for details: http://www.nature.com/nature/journal/v451/n7179/full/451658a.html. Tracing biological phenomena across scales of organization from gene-regulation to macroevolutionary novelties.
2.Use of Systems approaches to understand gene-regulation/interactions of cis-regulatory modules and transcription factors governing biomedically important genes in a) Myogenesis (work with bioinformaticians, Microfluidics engineers,Mathematicians, Statisticians and Physicists), b) fundamental mechanisms of skeletogenesis and biomineralization and its early evolution (work with palaeontologists and image analysis specialists).
3. Understanding the molecular and cellular aetiology of complex skeletomuscular and craniofacial diseases
in humans (Chiari I/II malformation and related syndromes).
4. Molecular dissection of Glioblastomas (work with Neuropathologists, bioinformaticians and others). Research Themes: Cell Biology; Developmental Biology; Neuroscience |
BACKGROUNDGerman High-school (Apostelgymnasium), focus on Classics and Biology. Final exam 1988;__ 1988-1989 Military service, German Army.__ 1989-1997: Fellow of German National Scholarship Foundation (Studienstiftung des Deutschen Volkes) for undergraduate and PhD studies.__ 1989-1994 Studies in Tuebingen and Freiburg: Trained in comparative vertebrate anatomy, genetics, palaeontology, vertebrate embryology and (largely) Greek philosophy. Diplombiologe (equivalent to BSc).__ 1994-1997:PhD with Professor Andrew Lumsden FRS in vertebrate embryology: Work on the role of neural crest in craniofacial pattern. This work discovered how neural crest segmentation is maintained in the segmentally specific pattern of skeleto-muscular connections. This work was awarded the Thomas Henry Huxley Prize 1998 for the best zoological PhD thesis in the UK/N.Ireland.__ 1997-2001: Human Frontiers Long term fellow and BASF special postdoctoral fellow at Harvard University. Also awarded EMBO fellowship (but I declined it). Work with Professor Catherine Dulac on the development and wiring of the olfactory system (pheromonal perception system): work on genetically tracing neuronal circuitry. Development of novel methods to expression-profile single cells on microarrays using laser-capture microscopy. __ April 2001-March 2007: Senior Lecturer in Functional Genomics and Evolutionary biology at UCL (WIBR). Discovery of a novel origin of the neck and shoulder region (Matsuoka et al. Nature 2005). Refocus of work into areas of gene-regulation within Stem cells. 2 Wellcome Trust Programme Grants, 1BBSRC Project grant, 1 ARC grant, several smaller grants. Since April 2007: Professor of Genomic Systems Biology and Evolution at the University of Warwick. Human Frontiers Programme Grant (as Principle Investigator), MRC grant, 2 Conquerchiari project grants. Focus on fundamental aspects of gene regulation and how these relate to anatomical features and how these have been subjected to evolutionary change . Work on the genetic foundation of the Arnold-Chiari malformation as a neurocristopathy, supported by ConquerChiari through two project grants. |
TEACHING PROFILECourses Taught
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SELECTED PUBLICATIONS
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My Profile last updated: 11/12/2012 |
my Nature Horizon article for which I was chosen by Nature among 7 researchers across all Natural Sciences. This outlines the scope of my research interests. For more current details, projects and findings please feel free to contact me by email or on skype: daidalos1969. 
