Dr Paul Squires

Paul Squires

TITLE   

Reader in Diabetes & Endocrinology and Director for Biomedicine

CONTACT   

Life Sciences
Room MB21
University of Warwick
Coventry
CV4 7Al 		Tel: 76572976
Fax: 02476523701
Email: P.E.Squires@warwick.ac.uk
Diabetes and endocrinology

 

RESEARCH PROFILE


1992-1995 Wellcome Trust Research Fellow, University of Sheffield, UK
1995-1996 Royal Society Traveling Research Fellow, UBC,Vancouver, Canada
1996-1997 Izaak Walton Killam Research Fellow, UBC, Vancouver, Canada
1997-2001 Diabetes UK, RD Lawrence Research Fellow, King's College London
1998 EASD/Bayer & Peter Baker Traveling Research Fellow, Uppsala, Sweden
2001-2005 Lecturer in Cellular Signalling, University of Warwick, UK
2001-2004 Honorary Lecturer, King's College London
2005-2010 Senior Lecturer Molecular Physiology, University of Warwick, UK
2010-present Reader in Diabetes & Endocrinology, University of Warwick, UK


My Research interests include elucidating sub-cellular mechanism that regulate insulin insulin secretion and action. A common avenue for both projects is the role of cell-to-cell communication in synchronising Ca2+-transients and function between cells of both the nephron and pancreatic islet.

RESEARCH GROUPS

BACKGROUND


I joined the University of Warwick in January 2001 following an RD Lawrence Research Fellowship (Diabetes UK) tenured at King's College London. I was awarded an Honorary Lectureship in the School of Biomedical Sciences KCL (2001-2004), and I'm a recipient of the Paul Langerhans Research Fellowship for Research on the Physiology and Pathophysiology of the pancreatic beta-cell (awarded by the European Association for the Study of Diabetes (EASD: 2001). I spent 3years at the University of British Columbia (UBC), Vancouver as a Royal Society Travelling Research Fellow and Honorary Fellow of the Izaak Walton Killam Memorial Foundation (1995-1998), and have also enjoyed a Travelling Research Fellowship at the University of Uppsala, Sweden (EASD/Bayer & Peter Baker). I'm currently Associate Professor (READER) within Life Sciences and Affiliate of the Warwick Medical School (WMS). I am Module Leader for Molecular Endocrinology (BS252)and participate in the teaching of numerous other modules both within WMS (Molecules of the Human Body) and Biological Sciences (Pharmacology (BS261), Physiology & Metabolism (BS129). I have been External Examiner for the MSc Programme in Biomedicine & Molecular Science Research, KCL (2005-2009) and I currently sit on the Research Advisory Boards for both Diabetes UK (DUK: 2005-present) and the Diabetes Research & Wellness Foundation (DRWF: 2010-present).

TEACHING PROFILE


Courses Taught

  • Yr1 Physiology Laboratory Classes [details]
      Reaction times
  • Molecular Endocrinology (BS252) [details]
      Module Leader
  • Yr2 Clinical Sciences Laboratories [details]
      CV and Respiration
  • Molecules of the Human Body (MBChB) [details]
      Endocrinology & diabetes (WMS)
  • Physiology & Metabolism (BS129) [details]
      CV Physiology
  • Pharmacology (BS261) [details]
      Treatment for diabetes mellitus

Learning, Teaching & Development Activity

  • Module leader
  • Postgraduate teaching (inc modules & project/research)
  • Personal tutoring

CURRENT RESEARCH PROJECTS


  • The effect of TGF-beta on connexin-mediated signalling: a role in diabetic nephropathy., with Dr Claire Hills - Biological Sciences, Funded by: Diabetes UK, Project Start Date: 01/10/2011 Project End Date: 30/09/2014
  • The importance of cell-to-cell contact in diabetic nephropathy: identifying potential novel targets for therapeutic intervention, with Dr Claire Hills - Life Sciences, Funded by: WPH Charitable Trust, Project Start Date: 01/03/2012 Project End Date: 28/02/2014
  • The effect of TGF-beta on cell adhesion, cell coupling & cell communication: a role in diabetic nephropathy, with Dr Claire Hills - Biological Sciences, Funded by: European Foundation for the Study of Diabetes (EFSD), Project Start Date: 01/10/2011 Project End Date: 31/05/2013

    View all Research Projects

SELECTED PUBLICATIONS


  • Yang GK, Squires PE, Tian F, Kieffer TJ, Kwok YN, Dale N.(2012) 'Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets' Islets 4 (1), 64 - 70 (1938-2014) [article]
  • Hills C.E., Siamantouras E., Smith S.W., Cockwell P., Liu K-K., Squires P.E.(2012) 'TGF-beta modulates cell-cell communication in early epithelial-to-mesenchymal transition' Diabetologia 55 (3), 812 - 824 (0012-186X) [article]
  • Hills, C.E. and Squires, P.E.(2011) 'The role of TGF-ß and epithelial-to mesenchymal transition in diabetic nephropathy' Cytokine and Growth Factor Reviews 22 (3), (1359-6101) [article]
  • Stratton, R. C., Squires, P. E. and Green, A. K.(2010) '17-beta-estradiol elevates cGMP and, via plasma membrane recruitment of protein kinase GI-alpha, stimulates Ca2+-efflux from rat hepatocytes.' Journal Of Biological Chemistry 285 (35), 27201 - 27212 (0021-9258) [article]
  • Hills, C. E., Brunskill, N. J. and Squires, P. E.(2010) 'C-peptide as a therapeutic tool in diabetic nephropathy' American Journal of Nephrology 31 (5), 389 - 397 (0250-8095) [article]

View all Publications

RESEARCH DEGREES SUPERVISED

  • Glycation and beta-cell function, Date of Completion: 2013
  • The structure/function and metabolic role of the CGRP receptor, Date of Completion: 2013
  • Specificity and cellular role of PDIp,a specialist and tissue-specific homologue of PDI, Date of Completion: 2012
  • CaR & cell-cell communication: from vesicle trafficking to insulin secretion., Date of Completion: 2011
  • E-CAD & cell adhesion: a role in architecture & function in the pancreatic islet, Date of Completion: 2007
  • SGK and disrupted renal sodium handling in diabetes, Date of Completion: 2006
Update My Profile on the Warwick eRA Portal My Profile last updated: 17/05/2012