RESEARCH PROFILE

• Role for neuronal-glial communication in brain disorders and brain ageing with particular focus pathological signaling mediated by
astroglial NMDA and P2X receptors;
• Role for neuron-glia communication in memory and cognition with particular focus to the homeostatic regulation of neural circuits in the framework of tripartite synapse;
• expression pattern and functional properties of glutamate and ATP receptors in brain astrocytes;
• Vesicular release of ATP from central synapses and its role in synaptic plasticity and development;
• Impact of ectopic release and spillover of neurotransmitters on
synaptic transmission in health and disease.

CURRENT RESEARCH PROJECTS

• RDF 2011/12 Strategic Award: Impact of Changes in gene expression and signalling in astrocytes on brain ageing, Funded by: Research Development Fund, Project Start Date: 01/08/2011 Project End Date: 31/07/2012
  
  

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SELECTED PUBLICATIONS

• Palygin, O., Lalo, U. and Pankratov, Y.(2011) 'Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes' British Journal Of Pharmacology 163 (8), 1755 - 1766 (0007-1188) [article]
• Canal Frederic; Palygin Oleg; Pankratov Yuriy; et al(2011) 'Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons' FASEB Journal 25 (7), 2362 - 2372 (0892-6638)
• Lalo, U., et al.(2011) 'Age-dependent remodelling of ionotropic signalling in cortical astroglia' Aging Cell 10 (3), 392 - 402 (1474-9726) [article]
• Lalo Ulyana; Verkhratsky Alexei; Pankratov Yuri(2011) 'Ionotropic ATP receptors in neuronal-glial communication' Seminars In Cell And Developmental Biology 22 (2), 220 - 228 (1084-9521)
• Palygin Oleg; Lalo Ulyana; Verkhratsky Alexei; et al(2010) 'Ionotropic NMDA and P2X(1/5) receptors mediate synaptically induced Ca(2+) signalling in cortical astrocytes' Cell Calcium 48 (4), 225 - 231 (0143-4160)

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