About the group
The evolution of various bacterial antibiotic resistance mechanisms, means that new antimicrobial compounds are urgently needed. The Roper group uses structural biology techniques, principally X-ray structural determination, in combination with molecular biology and biochemical approaches, to investigate the molecular basis of microbial physiology in relation to antibiotic resistance and bacterial cell wall (peptidoglycan) biosynthesis in Gram-positive and Gram-negative pathogens. In addition, the group also uses synthetic and translational biology approaches to obtain and reengineer pathway intermediates as chemical probes, substrates and inhibitors. This approach not only allows novel insight to the biology underpinning these pathways but also enables biotechnological exploration and exploitation.
The focus of our group is upon the enzymes involved in bacterial cell wall biosynthesis, which continues to be a validated target for the development of new antimicrobial compounds and strategies. In collaboration with Professor Chris Dowson in Life Sciences and Professor Tim Bugg in Chemistry, we use an interdisciplinary approach to study fundamental aspects of peptidoglycan biosynthesis, cell wall biosynthesis and explore the relationship between pathogenesis, bacterial growth and antimicrobial strategies.
Our activities coordinate with other groups on a national and international basis. Warwick has a central role in coordinating research in this area and at a national and international level. We also have a synthetic facility for the provision of peptidoglycan intermediates to the scientific and pharma community see www.warwick.ac.uk/go/bacwan for details.
For details of our work on antibiotic resistance please follow this link to a Warwick icast.
There are a range of projects ongoing within the group and we are always looking for new people interested in joining us. If you are interested in working with the group please contact David at david dot roper at warwick dot ac dot uk. Details on how to apply for a postgraduate position within the School of Life Sciences at Warwick can be found here.