Dr Deirdre Hollingsworth
Joint appointment between the Mathematics Institute and the
Life Sciences: Office: B0.08
I am an infectious disease epidemiologist who uses mathematical models and statistical analyses to study the evolution and transmission dynamics of infectious diseases with the aim of informing the design of more effective control interventions. I am particularly interested in neglected tropical diseases, a group of diseases which cause suffering amongst the poorest populations of the world. I am currently leading the NTD Modelling Consortium, an international network of neglected tropical disease modellers. My research foci are a group of intestinal worms (soil transmitted helminths or STHs) which affect a large number of children and adults in low income settings and the transmission and evolution of HIV in both Africa and European/North American settings. I have on-going research interests in the transmission dynamics of malaria and influenza.
University of Warwick and Liverpool School of Tropical Medicine: I have a joint appointment between mathematics and life sciences at the University of Warwick and the Liverpool School of Tropical Medicine (LSTM). This joint appointment provides a supportive environment for all aspects of my research, which involves mathematics, basic biology, clinical medicine and public health policy. The Centre for Applied Health Research and Delivery (CAHRD), in which I am based at Liverpool School of Tropical Medicine, is a cross-department virtual centre developing and successfully implementing effective, innovative, and affordable policies and practices, to scale, for the benefit of the health of poor populations. This collaboration between the University of Warwick and LSTM in the Centre is supported by a Wellcome Trust strategic award.
Infectious disease modelling at Warwick: I am a member of the Warwick Infectious Disease Epidemiology Research centre (WIDER), a cross-department, interdisciplinary group which has a long, prestigious history in research to understand and predict the spread and control of infectious diseases. We have weekly seminars which are open to attendees from across the university.
Students: If you are interested in applying for an infectious disease modelling PhD, WIDER is a partner in MathSys, an exciting new centre for doctoral training mathematics for real-world systems, which is funded by the EPSRC. There is also funding available under the Chancellor's Scholarship schemes (national and international), with a deadline in mid January. I am also interested in supervising undergraduate projects in mathematics and life sciences, both as part of your course or as part of the URSS scheme.
New publication: Fraser, C; Lythgoe, K; Leventhal, GE; Shirreff, G; Hollingsworth, TD; Alizon, S; Bonhoeffer, S (2014) Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective, Science, 343 (6177), 1328 (0036-8075).
Book chapter: Hollingsworth TD, Truscot JE, Anderson RM (2013). Chapter 9 - Transmission Dynamics of Ascaris lumbricoides – Theory and Observation. Ascaris: the Neglected Parasite. C. Holland. Amsterdam, Elsevier: 231-262.
NEW: Reviewed by R. Quinnell in Parasites and Vectors. He describes the book as "highly recommended" and an "excellent summary".
An Introduction to Infectious Disease Modelling, 1st April 2014. Organised by the Infectious Disease Research Network and hosted at Imperial College London in their Paddington campus.
If you are interested in learning more about infectious disease modelling, this is your opportunity to get a one day introduction!
As infectious-disease modelling becomes more mainstream, including through the development of user-friendly tools, it is increasingly important for public health professionals to understand what modelling can and cannot do, what its data requirements are, and how to critically appraise models. The best models are not necessarily those that are the most complicated or have the prettiest graphics!
Topics include use of models for economic evaluation, evidence synthesis, real-time analysis of outbreaks, scenario analysis, and informing policy; why infectious diseases are fundamentally different from non-infectious diseases and require specialised analysis; how different types of models represent the natural history of infections and heterogeneities in population risk. Diseases used as examples include influenza, TB, healthcare-associated infections, STIs & HIV, and vaccine-preventable infections. I will be one of the lecturers.
This event has been heavily subsidised and costs £25.06 to attend.
Invited presentations and seminars:
- Within-host disease dynamics, Workshop on emergence and spread of infectious diseases, Centre de Recerca Matemàtica, Barcelona, Spain. (June 2013)
Visiting Fellowship, Isaac Newton Institute of Mathematical Sciences, Cambridge.
Infectious Disease Dynamics Programme, August - September 2013
"On 1 January 2013, it was twenty years since Epidemic Models started as a 6-month programme in the first year of the Isaac Newton Institute for Mathematical Sciences. Since then, the field has grown enormously, in topics addressed, methods and data available (e.g. genetics/genomics, immunological data, social, contact, spatial, and movement data were hardly available at the time). As far as mathematical approaches are concerned, many methods currently used were either not available twenty years ago, or stayed firmly within mathematics and statistics because we could not recognise their importance for lack of the right data, or for lack of asking the right questions ... Apart from these advances, there has also been an increase in the need for these approaches because we have seen the emergence and re-emergence of infectious agents worldwide, and the complexity and non-linearity of infection dynamics, as well as effects of prevention and control, are such that mathematical and statistical analysis is essential for insight and prediction, now more than ever before."
Outreach and Public Engagement:
- Maths & Beyond (March 2014): Interactive 1 hour lectures for Year 10 and 11 pupils for the Further Maths Support Centre based at the University of Warwick.
- Standing up for Science, Sense about Science, (June 2013): The Voice of Young Science Standing up for Science media workshops encourage early career researchers to get their voices heard in public debates about science. During the workshops we discuss concerns about speaking to the public and confront misconceptions about how the media works.
- PUBLIC LECTURE: "Surviving the Next Pandemic", Edinburgh Science Festival, 2nd April 2013; "contemporary, fascinating and very engaging" according to The Student
Honorary Lecturer, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London.
A full publication list is available here.
My publications are also available on: Pubmed (almost complete, links to free full texts, through Pubmed Central and elsewhere), ORCID, Google Scholar (links to free texts), Research Gate, ResearcherID (requires institutional/personal subscription) and Scopus (requires institutional/personal subscription for full functionality).
Soil transmitted helminths
- Hollingsworth TD, Truscot JE, Anderson RM (2013). Chapter 9 - Transmission Dynamics of Ascaris lumbricoides – Theory and Observation. Ascaris: the Neglected Parasite. C. Holland. Amsterdam, Elsevier: 231-262.
- Anderson RM; Truscott JE; Pullan R; Brooker S; Hollingsworth TD. (2013). How Effective Is School-Based Deworming for the Community-Wide Control of Soil-Transmitted Helminths?. PLOS Negl Trop Diseases. 7(2): e2027. Described as a identifying a "key log" for future policy development.
- Anderson R; Hollingsworth TD; Truscott J; Brooker S. (2012). Optimisation of mass chemotherapy to control soil-transmitted helminth infection. The Lancet. 379:289-290.
- Fraser, C; Lythgoe, K; Leventhal, GE; Shirreff, G; Hollingsworth, TD; Alizon, S; Bonhoeffer, S (2014) Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective, Science, 343 (6177), 1328 (0036-8075).
- Baggaley RF; White RG; Hollingsworth TD; Boily MC. (2013). Heterosexual HIV-1 Infectiousness and Antiretroviral Use: Systematic Review of Prospective Studies of Discordant Couples. Epidemiology. 1:110-121.
- Hollingsworth TD; Laeyendecker O; Shirreff G; Donnelly CA; Serwadda D; Wawer MJ; Kiwanuka N; Nalugoda F; et alCollinson-Streng A; Ssempijja V; Hanage WP; Quinn TC; Gray RH; Fraser C. (2010). HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda. PLoS Pathog. 6:e1000876. (open access)
- Hollingsworth TD; Anderson RM; Fraser C. (2008). HIV-1 transmission, by stage of infection. J Infect Dis. 198:687-693. Cited >190 times (ISI)
- Fraser C; Hollingsworth TD; Chapman R; de Wolf F; Hanage WP. (2007). Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis. Proc Natl Acad Sci U S A. 104:17441-17446. Nominated for The Lancet Paper of the Year 2007
- Griffin JT; Hollingsworth TD; Okell LC; Churcher TS; White M; Hinsley W; Bousema T; Drakeley CJ; et alFerguson NM; Basáñez MG; Ghani AC. (2010). Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. PLoS Med. 7. (open access)
- Hollingsworth TD; Klinkenberg D; Heesterbeek H; Anderson RM. (2011). Mitigation strategies for pandemic influenza A: balancing conflicting policy objectives. PLoS Comput Biol. 7:e1001076. (open access). Lecture at the Newton Institute
- Hollingsworth TD. (2009). Controlling infectious disease outbreaks: Lessons from mathematical modelling. J Public Health Policy. 30:328-341.
- Fraser C; Donnelly CA; Cauchemez S; Hanage WP; Van Kerkhove MD; Hollingsworth TD; et al. (2009). Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings. Science. 324:1557-1561. (open access)
- Hollingsworth TD; Ferguson NM; Anderson RM. (2007). Frequent travelers and rate of spread of epidemics. Emerg Infect Dis. 13:1288-1294. (open access)
- Hollingsworth TD; Ferguson NM; Anderson RM. (2006). Will travel restrictions control the international spread of pandemic influenza?. Nat Med. 12:497-499.