Dr Deirdre Hollingsworth
Life Sciences: Office: B0.08
I am an infectious disease epidemiologist who uses mathematical models and statistical analyses to study the evolution and transmission dynamics of infectious diseases with the aim of informing the design of more effective control interventions. My current research foci are a group of intestinal worms (soil transmitted helminths or STHs) which affect a large number of children and adults in low income settings and the transmission and evolution of HIV in both Africa and European/North American settings. I have on-going research interests in the transmission dynamics of malaria and influenza.
The Centre for Applied Health Research and Delivery (CAHRD) at LSTM, in which I am based, is a cross-department virtual centre developing and successfully implementing effective, innovative, and affordable policies and practices, to scale, for the benefit of the health of poor populations. This collaboration between the University of Warwick and LSTM in the Centre is supported by a Wellcome Trust strategic award.
I am also a member of the Warwick Infectious Disease Epidemiology Research centre (WIDER), a cross-department, interdisciplinary group who focus on understanding and predicting the spread and control of infectious diseases.
|New book chapter: Hollingsworth TD, Truscot JE, Anderson RM (2013). Chapter 9 - Transmission Dynamics of Ascaris lumbricoides – Theory and Observation. Ascaris: the Neglected Parasite. C. Holland. Amsterdam, Elsevier: 231-262.|
Recent Publication: Anderson RM, Truscott JE, Pullan RL, Brooker SJ, Hollingsworth TD (2013) How Effective Is School-Based Deworming for the Community-Wide Control of Soil-Transmitted Helminths? PLoS Negl Trop Dis 7(2): e2027.
The analysis is described as a identifying a "key log" for future policy development in an accompanying commentary by David Addiss, Director of Children Without Worms: Addiss DG (2013) Epidemiologic Models, Key Logs, and Realizing the Promise of WHA 54.19. PLoS Negl Trop Dis 7(2): e2092.
Visiting Fellowship, Isaac Newton Institute of Mathematical Sciences, Cambridge.Infectious Disease Dynamics Programme
August - September 2013
"On 1 January 2013, it was twenty years since Epidemic Models started as a 6-month programme in the first year of the Isaac Newton Institute for Mathematical Sciences. Since then, the field has grown enormously, in topics addressed, methods and data available (e.g. genetics/genomics, immunological data, social, contact, spatial, and movement data were hardly available at the time). As far as mathematical approaches are concerned, many methods currently used were either not available twenty years ago, or stayed firmly within mathematics and statistics because we could not recognise their importance for lack of the right data, or for lack of asking the right questions ... Apart from these advances, there has also been an increase in the need for these approaches because we have seen the emergence and re-emergence of infectious agents worldwide, and the complexity and non-linearity of infection dynamics, as well as effects of prevention and control, are such that mathematical and statistical analysis is essential for insight and prediction, now more than ever before."
Invited presentations and seminars:
- Within-host disease dynamics, Workshop on emergence and spread of infectious diseases, Centre de Recerca Matemàtica, Barcelona, Spain. (June 2013)
Outreach and Public Engagement:
- Standing up for Science, Sense about Science, (June 2013): The Voice of Young Science Standing up for Science media workshops encourage early career researchers to get their voices heard in public debates about science. During the workshops we discuss concerns about speaking to the public and confront misconceptions about how the media works.
- PUBLIC LECTURE: "Surviving the Next Pandemic", Edinburgh Science Festival, 2nd April 2013; "contemporary, fascinating and very engaging" according to The Student
Honorary Lecturer, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London.
My publications are also available on: Pubmed (almost complete, links to free full texts, through Pubmed Central and elsewhere), ORCID, Google Scholar (links to free texts), ResearcherID (requires institutional/personal subscription) and Scopus (requires institutional/personal subscription for full functionality).
Soil transmitted helminths
- Hollingsworth TD, Truscot JE, Anderson RM (2013). Chapter 9 - Transmission Dynamics of Ascaris lumbricoides – Theory and Observation. Ascaris: the Neglected Parasite. C. Holland. Amsterdam, Elsevier: 231-262.
- Anderson RM; Truscott JE; Pullan R; Brooker S; Hollingsworth TD. (2013). How Effective Is School-Based Deworming for the Community-Wide Control of Soil-Transmitted Helminths?. PLOS Negl Trop Diseases. 7(2): e2027. (open access)
- Anderson R; Hollingsworth TD; Truscott J; Brooker S. (2012). Optimisation of mass chemotherapy to control soil-transmitted helminth infection. The Lancet. 379:289-290.
- Baggaley RF; White RG; Hollingsworth TD; Boily MC. (2013). Heterosexual HIV-1 Infectiousness and Antiretroviral Use: Systematic Review of Prospective Studies of Discordant Couples. Epidemiology. 1:110-121.
- Hollingsworth TD; Laeyendecker O; Shirreff G; Donnelly CA; Serwadda D; Wawer MJ; Kiwanuka N; Nalugoda F; et alCollinson-Streng A; Ssempijja V; Hanage WP; Quinn TC; Gray RH; Fraser C. (2010). HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda. PLoS Pathog. 6:e1000876. (open access)
- Hollingsworth TD; Anderson RM; Fraser C. (2008). HIV-1 transmission, by stage of infection. J Infect Dis. 198:687-693.
- Fraser C; Hollingsworth TD; Chapman R; de Wolf F; Hanage WP. (2007). Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis. Proc Natl Acad Sci U S A. 104:17441-17446. (open access)
- Griffin JT; Hollingsworth TD; Okell LC; Churcher TS; White M; Hinsley W; Bousema T; Drakeley CJ; et alFerguson NM; Basáñez MG; Ghani AC. (2010). Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. PLoS Med. 7. (open access)
- Hollingsworth TD; Klinkenberg D; Heesterbeek H; Anderson RM. (2011). Mitigation strategies for pandemic influenza A: balancing conflicting policy objectives. PLoS Comput Biol. 7:e1001076. (open access)
- Hollingsworth TD. (2009). Controlling infectious disease outbreaks: Lessons from mathematical modelling. J Public Health Policy. 30:328-341.
- Fraser C; Donnelly CA; Cauchemez S; Hanage WP; Van Kerkhove MD; Hollingsworth TD; et al. (2009). Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings. Science. 324:1557-1561. (open access)
- Hollingsworth TD; Ferguson NM; Anderson RM. (2007). Frequent travelers and rate of spread of epidemics. Emerg Infect Dis. 13:1288-1294. (open access)
- Hollingsworth TD; Ferguson NM; Anderson RM. (2006). Will travel restrictions control the international spread of pandemic influenza?. Nat Med. 12:497-499.