Dr Deirdre Hollingsworth
Joint appointment between the Mathematics Institute and the
Life Sciences: Office: B0.08
I am an infectious disease epidemiologist who uses mathematical models and statistical analyses to study the evolution and transmission dynamics of infectious diseases with the aim of informing the design of more effective control interventions. I am particularly interested in neglected tropical diseases, a group of diseases which cause suffering amongst the poorest populations of the world. I am currently leading the NTD Modelling Consortium, an international network of neglected tropical disease modellers. My research foci are a group of intestinal worms (soil transmitted helminths or STHs) which affect a large number of children and adults in low income settings and the transmission and evolution of HIV in both Africa and European/North American settings. I have on-going research interests in the transmission dynamics of malaria and influenza.
University of Warwick and Liverpool School of Tropical Medicine: I have a joint appointment between mathematics and life sciences at the University of Warwick and the Liverpool School of Tropical Medicine (LSTM). This joint appointment provides a supportive environment for all aspects of my research, which involves mathematics, basic biology, clinical medicine and public health policy. The Centre for Applied Health Research and Delivery (CAHRD), in which I am based at Liverpool School of Tropical Medicine, is a cross-department virtual centre developing and successfully implementing effective, innovative, and affordable policies and practices, to scale, for the benefit of the health of poor populations. This collaboration between the University of Warwick and LSTM in the Centre is supported by a Wellcome Trust strategic award.
Infectious disease modelling at Warwick: I am a member of the Warwick Infectious Disease Epidemiology Research centre (WIDER), a cross-department, interdisciplinary group which has a long, prestigious history in research to understand and predict the spread and control of infectious diseases. We have weekly seminars which are open to attendees from across the university.
Students: If you are interested in applying for an infectious disease modelling PhD, WIDER is a partner in MathSys, an exciting new centre for doctoral training mathematics for real-world systems, which is funded by the EPSRC. There is also funding available under the Chancellor's Scholarship schemes (national and international), with a deadline in mid January. I am also interested in supervising undergraduate projects in mathematics and life sciences, both as part of your course or as part of the URSS scheme.
Mon 04 Aug '14
Outreach and Public Engagement:
- Soapbox Science (June 2014): Interactive event modelled around "Speakers' Corner" where scientists stand on a soapbox for an hour on the South Bank in London enthusing the public about science.
- Maths & Beyond (March 2014): Interactive 1 hour lectures for Year 10 and 11 pupils for the Further Maths Support Centre based at the University of Warwick.
- Standing up for Science, Sense about Science, (June 2013): The Voice of Young Science Standing up for Science media workshops encourage early career researchers to get their voices heard in public debates about science. During the workshops we discuss concerns about speaking to the public and confront misconceptions about how the media works.
- PUBLIC LECTURE: "Surviving the Next Pandemic", Edinburgh Science Festival, 2nd April 2013; "contemporary, fascinating and very engaging" according to The Student
Tue 10 Jun '14
Honorary Lecturer, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London.
A full publication list is available here.
Tue 10 Jun '14
Open access publication finds treatment levels and frequency need to be higher to cut transmission of soil-transmitted helminths
Open access publication in the Philosophical Transactions of the Royal Society on control of soil-transmitted helminths
Key publications by disease:
Soil transmitted helminths
- Truscott JE*; Hollingsworth TD*; Brooker SJ; Anderson RM (2014). Can chemotherapy alone eliminate the transmission of soil transmitted helminths? Parasites and Vectors. 7:266. (open access, highly accessed)
Anderson RM; Truscott JE; Hollingsworth TD (2014). The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths. Philosophical Transactions of the Royal Society B. 369 (1645): 20130435. One contribution of 12 to a Theme Issue ‘After 2015: infectious diseases in a new era of health and development’. (open access)
- Hollingsworth TD, Truscot JE, Anderson RM (2013). Chapter 9 - Transmission Dynamics of Ascaris lumbricoides – Theory and Observation. Ascaris: the Neglected Parasite. C. Holland. Amsterdam, Elsevier: 231-262.
- Anderson RM; Truscott JE; Pullan R; Brooker S; Hollingsworth TD. (2013). How Effective Is School-Based Deworming for the Community-Wide Control of Soil-Transmitted Helminths?. PLOS Negl Trop Diseases. 7(2): e2027. (open access) Described as a identifying a "key log" for future policy development.
- Anderson R; Hollingsworth TD; Truscott J; Brooker S. (2012). Optimisation of mass chemotherapy to control soil-transmitted helminth infection. The Lancet. 379:289-290.
- Fraser, C; Lythgoe, K; Leventhal, GE; Shirreff, G; Hollingsworth, TD; Alizon, S; Bonhoeffer, S (2014) Virulence and Pathogenesis of HIV-1 Infection: An Evolutionary Perspective, Science, 343 (6177), 1328 (0036-8075).
- Baggaley RF; White RG; Hollingsworth TD; Boily MC. (2013). Heterosexual HIV-1 Infectiousness and Antiretroviral Use: Systematic Review of Prospective Studies of Discordant Couples. Epidemiology. 1:110-121.
- Hollingsworth TD; Laeyendecker O; Shirreff G; Donnelly CA; Serwadda D; Wawer MJ; Kiwanuka N; Nalugoda F; et alCollinson-Streng A; Ssempijja V; Hanage WP; Quinn TC; Gray RH; Fraser C. (2010). HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda. PLoS Pathog. 6:e1000876. (open access)
- Hollingsworth TD; Anderson RM; Fraser C. (2008). HIV-1 transmission, by stage of infection. J Infect Dis. 198:687-693. Cited >200 times (ISI)
- Fraser C; Hollingsworth TD; Chapman R; de Wolf F; Hanage WP. (2007). Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis. Proc Natl Acad Sci U S A. 104:17441-17446. Nominated for The Lancet Paper of the Year 2007
- Pinsent A; Read JM; Griffin JT; Smith V; Gething PW; Ghani AC; Pasvol G; Hollingsworth TD. (2014). Risk factors for UK Plasmodium falciparum cases.
Malaria Journal 13:298 doi:10.1186/1475-2875-13-298 (open access, highly accessed).
- Griffin JT; Hollingsworth TD; Okell LC; Churcher TS; White M; Hinsley W; Bousema T; Drakeley CJ; Ferguson NM; Basáñez MG; Ghani AC. (2010). Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. PLoS Med. 7. (open access)
- Hollingsworth TD; Klinkenberg D; Heesterbeek H; Anderson RM. (2011). Mitigation strategies for pandemic influenza A: balancing conflicting policy objectives. PLoS Comput Biol. 7:e1001076. (open access). Lecture at the Newton Institute
- Hollingsworth TD. (2009). Controlling infectious disease outbreaks: Lessons from mathematical modelling. J Public Health Policy. 30:328-341.
- Fraser C; Donnelly CA; Cauchemez S; Hanage WP; Van Kerkhove MD; Hollingsworth TD; et al. (2009). Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings. Science. 324:1557-1561. (open access)
- Hollingsworth TD; Ferguson NM; Anderson RM. (2007). Frequent travelers and rate of spread of epidemics. Emerg Infect Dis. 13:1288-1294. (open access)
- Hollingsworth TD; Ferguson NM; Anderson RM. (2006). Will travel restrictions control the international spread of pandemic influenza? Nat Med. 12:497-499.
- Metcalf CJE, Andreasen V, Bjornstad ON, Eames K, Edmunds WJ, Funk S, Hollingsworth TD, Lessler J, Viboud C, Grenfell BT (2014) Seven challenges in modelling vaccine preventable diseases, Epidemics, In press
- Hollingsworth TD, Pulliam JRC, Funk S, Truscott JE, Isham V, Lloyd AL. (2014). Seven challenges for modelling indirect transmission: vector-borne diseases, macroparasites and neglected tropical diseases. Epidemics. in press.