Hashem Koohy

I awarded my first PhD in pure mathematics (Rings and Modules) from the Ahvaz University in Iran. There, I developed the notion of the Prime submodels which are a generalisation of prime ideals in Rings to Modules. For a list of my publications in pure mathematics, you can look through A.M.S Reviews.

During my first visit to the Warwick Mathematics Institute (WMI) in 2003-2004 I became interested in applications of mathematics in biological sciences. I awarded an MSc in Molecular Organisation and Assembly in Cells (MOAC) in 2007 and then awarded my second PhD in transciptional regulation from MOAD and Warwick Systems Biology Centre at 2010. My main focus over my PhD was to undestand more about the transciptional regulatory code. I developed a mathematical model called Regulatory Region Scoring Model (RRS) that is providing us with more insights about how gene exression patterns are integrated in regulatory sequences. More details of this model plus one of its application is now online. Detection of regulatory regions of the GH146 enhancer in Drosophila melanogaster is anathor application of this model (a close collaboration with Stanford University). The manuscript of this project is under prepration and will be submitted soon.

Here, you can see a poster that I presented recently in Cold Spring Harbor myposter.pdf

Currently, I work as a post doctoral fellowship in Sanger Institute at Cambridge University under the supervison of Dr. Tim Hubbard. In particular, I am involved in two projects:

First I want to see how computationally detected motifs (from algorithms such as NestedMICA and MEME) are consistent with those detected by bilological techniques such as chip-chip and chi-seq. This is a genome wide comparison over the human genome.

Second to use a three-states HMM (origianlly established by Thomas Down) to detect ehcancers in human genome and then denote them over the genome. For this I would train the model in a less complicated genome with a handful of known enhancers such as D.melanogaster genome and then I would apply it to the human genome. I have just started making a blog for myself which I have called it Narestan and I will put more information (both personal and work related things) into it.

Here, is my CV in which you can see my most recent publications CV