The Medical Physics group at the University of Warwick works in tandem with University Hospitals Coventry and Warwickshire (UHCW) to provide research opportunities for both undergraduate and postgraduate students. Led by Dr Jon Duffy at Warwick and Dr Spyros Manolopoulos at UHCW.
email: j dot a dot rogers at warwick dot ac dot uk
Research Project: Biological Imaging for Adaptive Radiotherapy
The aim of this project is to use biological imaging methods such as Diffusion-Weighted MRI or PET/CT to inform and individually adapt the radiotherapy treatment of patients.
Radiotherapy treatments using high energy X-rays are planned to focus on a tumour in order to kill cancer cells whilst minimizing the potential toxicity to normal, healthy cells nearby. Computed Tomography images of the patient are used for this purpose, and radiation doses can be calculated to within millimetres accuracy. Newer, biological or molecular imaging techniques which are already in use for diagnosis can add information regarding the functionality of tumours, for example to allow radiation dose boosts to more prolific sub-volumes of tumour (thereby potentially increasing the probability of tumour response), or alternatively reductions in dose to potentially reduce the toxicity of treatment.
email: s dot manger at warwick dot ac dot uk
Research Project: Radiation Damage in Proton CT
The development of proton computed tomography (pCT) will aid proton therapy by allowing the patient be imaged using the treatment beam and also by directly measuring the water-equivalent path length of the patient. This should reduce uncertainties in proton range in-vivo and increase plan robustness.
The technologies used in pCT may be susceptible to radiation damage. The PRAVDA project uses a number of CMOS sensors to measure the residual range of the proton upon exiting the patient. Each image will deposit dose in the CMOS sensor, potentially inhibiting it's performance. My research studies how the performance of the sensor changes with deposited dose and the effect that has on the full reconstruction and corresponding dose map.