Student Publications
Note to Systems Biology students:
The list below contains a list of most Systems Biology DTC publications. If you notice one is missing please send the reference to p.e.brown@warwick.ac.uk with a request to add it.
Please also make sure you're familiar with the University of Warwick's open access policy, and publication protocol 
(pay particular attention to points 1,4, and annexe A).
Regulation of the expression and activity of Unr in mammalian cells
Anderson EC, Catnaigh PÓ
Biochem Soc Trans (2015) 43 (6): 1241-6. doi: 10.1042/BST20150165
Unr (upstream of N-ras) is a post-transcriptional regulator of gene expression, essential for mammalian development and mutated in many human cancers. The expression of unr is itself regulated at many levels; transcription of unr, which also affects expression of the downstream N-ras gene, is tissue and developmental stage-dependent and is repressed by c-Myc and Max (Myc associated factor X). Alternative splicing gives rise to six transcript variants, which include three different 5'-UTRs. The transcripts are further diversified by the use of three alternative polyadenylation signals, which governs whether AU-rich instability elements are present in the 3'-UTR or not. Translation of at least some unr transcripts can occur by internal initiation and is regulated in a cell-cycle-dependent manner; binding of PTB (polypyrimidine tract-binding protein) and Unr to the 5'-UTR inhibits translation, but these are displaced by heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNPC1/C2) during mitosis to stimulate translation. Finally, Unr is post-translationally modified by phosphorylation and lysine acetylation, although it is not yet known how these modifications affect Unr activity.