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Professor Bärbel Finkenstädt Rand, PhD Director

About my research interests

My area of research is in statistics and mathematical biology. In particular, I am interested in analysing temporal and/or spatio-temporal data from biological systems (from single cells to meta-populations). My recent collaborations include addressing questions in chronobiology with collaborators in the Biological Sciences and Medicine. In collaboration with Francis Lévi (see video) and members of the Chronotherapy group at Warwick Medical School, Warwick Systems Biology and INSERM France, I am researching statistical methods for non-stationary statistical modeling and inference for circadian oscillations for research in cancer chronotherapy.

Current or recent PhD students: Silvia Calderazzo, Simone Tiberi, Panayiota Touloupou (with S Spencer), Elena Camacho- Aguilar (with D Rand), Mans Unosson (with A Johanson), Beniamino Hadj-Amar (OxWaSp DTC).

Postdoctoral Collaborators on Research Grants: Qi Huang, Giorgos Minas, Hiroshi Momiji.

Current Collaborators in Systems Biology and Medecine:

David Rand, Michael White, Julian Davis, PRESTA group, Francis Lévi, Mike Hastings

Some recent publications

Featherstone, K., Hey, K., Momiji, H., McNamara, A.V., Patist, A.L., Woodburn, J., Spiller, D.G., Christian, H.C., McNeilly, A.S., Mullins, J.J., Finkenstädt, B., Rand, D.A., White, M.R.H., Davis, J.R.E. (2015) Spatially Coordinated Dynamic Gene Transcription in Living Pituitary Tissue, eLife 2016;5:e08494

Kirsty L. Hey, Hiroshi Momiji, Karen Featherstone, Julian R.E. Davis, Michael R.H. White, David A. Rand, and Bärbel Finkenstädt, A stochastic transcriptional switch model for single cell imaging data
Biostatistics 2015, Vol.16, No. 4, 655-69.  doi:10.1093/biostatistics/kxv010

Sidaway-Lee, K., Costa, M.J., Rand, D.A., Finkenstädt, B. and Penfield, S. (2014), Direct measurement of transcription rates reveals multiple mechanisms for configuration of the Arabidopsis ambient temperature response, Genome Biology 2014, 15:R45 (3 March 2014).

Finkenstädt , B., Woodcock, D.J., Komorowski, M. , Harper, C.V., Davis, J.R.E., White, M.R.H., Rand, D. A., (2013), Quantifying intrinsic and extrinsic noise in gene transcription using the linear noise approximation: an application to single cell data, Annals of Applied Statistics 2013, Vol. 7, No. 4, 1960–1982.

Costa M.J., Finkenstädt, B., Gould, P.D, Foreman, J., Halliday, K., Hall, A., Roche, V., Levi, F. and Rand, D.A., (2013), Inference on periodicity of circadian time series, Biostatistics 2013, 14(4):792-806. doi: 10.1093/biostatistics/kxt020.

Woodcock, DJ, Vance KW, Komorowski, M, Koentges G, Finkenstädt, B and Rand, DA, (2013), A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number, Bioinformatics 2013, 29 (12): 1519-1525. doi: 10.1093/bioinformatics/btt201.

Dafyd J. Jenkins; Barbel Finkenstädt; David A. Rand (2013), A temporal switch model for estimating transcriptional activity in gene expression. Bioinformatics 2013 May 1; 29(9): 1158–1165. doi:10.1093/bioinformatics/btt111 (link)

Peter D Gould, Nicolas Ugarte, Mirela Domijan, Maria Costa, Julia Foreman, Dana MacGregor, Ken Rose, Jayne Griffiths, Andrew J Millar, Bärbel Finkenstädt, Steven Penfield, David A Rand, Karen J Halliday & Anthony J W Hall (2013), Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures, Molecular Systems Biology 2013 9:650; doi:10.1038/msb.2013.7; (link)

Windram O, Madhou P, McHattie S, Hickman R, Cooke E, Jenkins DJ, Penfold CA, Baxter L, Breeze E, Kiddle SJ, Rhodes J, Atwell S, Kliebenstein DJ, Kim Y-S, Stegle O, Borgwardt K, Zhang C, Tabrett A, Legaie R, Moore J, Finkenstädt B, Wild DL, Mead A, Rand DA, Beynon J, Ott S, Buchanan-Wollaston V, Denby KJ (2012) Arabidopsis defence against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis, Plant Cell 2012 24 (10), 3949 - 3965; (link)

Ferreira, M., Finkenstädt , B., Oliveira, B.M.P.M., Pinto, Alberto A. and A.N. Yannacopoulos, (2012), On the convergence to Walrasian prices in random matching Edgeworthian economies, Central European Journal of Operations Research (CJOR) 2012, 20 (3), pp 485-495 (link)

Harper CV, Finkenstädt B, Woodcock DJ, Friedrichsen S, Semprini S, et al. (2011) Dynamic Analysis of Stochastic Transcription Cycles. PLoS Biology 2011 9(4): e1000607. doi:10.1371/journal.pbio.1000607 (link)

Rittman M, Hoffmann SV, Gilroy E, Hicks MR, Finkenstädt B, Rodger A (2011) Probing the structure of long DNA molecules in solution using synchrotron radiation linear dichroism. Physical Chemistry Chemical Physics (PCCP) 2011, 14, 353-366 DOI: 10.1039/C1CP22371B; (link)

Ferreira, M., Finkenstädt , B., Oliveira, B.M.P.M., Pinto, Alberto A. and A.N. Yannacopoulos, (2011), A modified model of an Edgeworthian Economy, in Dynamics, Games and Science I (eds. M.M. Peixoto et al.), Springer Proceedings in Mathematics 2011, DOI 10.1007/978-3-642-11456-4_21, Springer Verlag, Berlin Heidelberg 2011.

Komorowski, M. , Finkenstädt , B., Rand, D. A. , (2010); Using single fluorescent reporter gene to infer half-life of extrinsic noise and other parameters of gene expression, Biophysical Journal 2010, Vol 98, Issue 12, 2759-2769, online at http://www.cell.com/biophysj/

Komorowski, M. , Finkenstädt , B., Harper, C. V., Rand, D. A. , (2009); Bayesian inference of biochemical kinetic parameters using the linear noise approximation, BMC Bioinformatics 2009, 10:343 doi:10.1186/1471-2105-10-343, 2009, online at: http://www.biomedcentral.com/1471-2105/10/343

B. Finkenstadt; E. A. Heron; M. Komorowski; K. Edwards; S. Tang; C. V. Harper; J. R. E. Davis; M. R. H. White; A. J. Millar; D. A. Rand, (2008); Reconstruction of transcriptional dynamics from gene reporter data using differential equations, Bioinformatics  2008; 24: 2901 - 2907; (link)

Heron, E., Finkenstädt, B. F. and Rand, D.A., (2007), Bayesian Inference for dynamic transcriptional regulation; the Hes1 system as a case study. Bioinformatics 2007, 23 (19), 2589-2595; (link)

Lekone, P.E. and Finkenstädt, B. F., (2006), Statistical Inference in a stochastic epidemic SEIR model with control intervention: Ebola as a case study. Biometrics, 2006 (62), 1170-1177.

Finkenstädt, B. F. , Held L. and Isham, V. (eds), 2006, Statistical Methods for Spatio-temporal systems, CRC Press/Chapman and Hall.

Finkenstädt, B. F., Morton, A.M and Rand, D. A. (2005), Modelling antigenic drift in weekly flu incidence. Statistics in Medicine, 2005 (24), 3447-3461.

Morton, A.M. and Finkenstädt, B. F. (2005) Discrete-time modelling of disease incidence time series by using Markov Chain Monte Carlo methods, J. R. Statist. Soc. C., Applied Statistics, 54 (3), 575-594.


 selfie



Office hours
Academic year 16/17:
Mondays 9:30-10:30
Wednesdays 16:00 - 17:00
END OF TERM:
Wedn 7 Dec 15:00 - 16:00
Friday 9 Dec 11:00 - 12:00
(these are in addition to the regular hours above)



email: Barbel.Finkenstadt 'at' warwick.ac.uk

Telephone: 024 7657 2580