On 23 & 24 January 2012 the Warwick Department of Statistics hosted the "GlaxoSmithKline - Neurophysics Workshop on Pharmacological MRI", an activity coordinated with the Neurophysics Marie Curie Initial Training Network of which GSK is a participant. The first day provided review of fundamentals of MR imaging of the brain, and how MR & PET are presently used in the drug development process. The second day highlighted cutting-edge techniques which may form pH MRI methods of tomorrow.

The event was organized by Paul Matthews, GlaxoSmithKline Global Imaging Unit, and Thomas Nichols, University of Warwick Department of Statistics and Warwick Manufacturing Group.

Monday 23 Jan - Data acquisition for pH MRI

• Principles of pharmacological modelling relevant to applications of imaging endpoints. Chao Chen & ampStefano Zamuner, GlaxoSmithKline
• Principles of haemodynamic coupling. Paul Matthews, GSK Global Imaging Unit and Imperial College, London
• BOLD contrast and its measurement. Rex Newbould, Imanova, Ltd.
• pHMRI principles and confounds. Richard Wise, Cardiff University
• ASL methods and potential for pH MRI. Michael Kelly, Oxford FMRIB Centre
• Model based analyses, direct and indirect PK modelling. Roger Gunn, Imanova, Ltd. and Imperial College, London
• Multimodal approaches to functional neuroimaging. Peter Morris, Nottingham University

Tuesday 24 Jan - New frontiers in pH MRI and data analysis

• Identifying FMRI signatures of drug action from past studies for the screening of novel compounds. Eugene Duff, Oxford FMRIB Centre
• Stochastic DCM for resting-state fMRI. Ged Ridgway, FIL, University College, London
• Network analyses for fMRI. Petra Vertes, University of Cambridge
• Weighted graph analysis for groups. Cedric Ginestet, Kings College London
• Detecting global treatment effects across ROIs. George Minas, University of Warwick
• Analysis of longitudinal imaging data. Bryan Guillaume, Liège & Warwick Universities