Recent publications

• Extracting regulator activity profiles by integration of de novo motifs and expression data: characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor. Iqbal M., Mast Y., Amin R., Hodgson D. A., The STREAM Consortium , Wohlleben W., Burroughs N. J. NAR (2012) 1-13. Open Access.
• Metabolic Switches and Adaptations Deduced from the Proteomes of Streptomyces coelicolor Wild Type and phoP Mutant Grown in Batch Culture. Thomas, L (Thomas, Louise); Hodgson, DA (Hodgson, David A.); Wentzel, A (Wentzel, Alexander); Nieselt, K (Nieselt, Kay); Ellingsen, TE (Ellingsen, Trond E.); Moore, J (Moore, Jonathan); Morrissey, ER (Morrissey, Edward R.); Legaie, R (Legaie, Roxane); Wohlleben, W (Wohlleben, Wolfgang); Rodriguez-Garcia, A (Rodriguez-Garcia, Antonio); Martin, JF (Martin, Juan F.); Burroughs, NJ (Burroughs, Nigel J.); Wellington, EMH (Wellington, Elizabeth M. H.); Smith, MCM. Molecular and Cellular Proteomics. 11 (2012).
• Semi-automated Acanthamoeba polyphaga detection and computation of Salmonella typhimurium concentration in spatio-temporal images. Tsibidis, GD (Tsibidis, George D.); Burroughs, NJ (Burroughs, Nigel J.); Gaze, W (Gaze, William); Wellington, EMH (Wellington, Elizabeth M. H.). MICRON 42 (2011) 911-920.

• Loss of the SPHF Homologue Slr1768 leads to a Catastrophic Failure in the Maintenance of Thylakoid Membranes in Synechocystis sp. PCC 6803. Samantha J. Bryan, Nigel J Burroughs, Carol Evered, Joanna Sacharz, Anja Nenninger, Conrad W Mullineaux and Edward M. Spence. PLoS ONE 6(5): e19625. doi:10.1371/journal.pone.0019625. Open Access. IF 4.35.

• Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses. Nigel J. Burroughs, Karsten Kohler, Vladimir Miloserdov, Michael L. Dustin, P. Anton van der Merwe, Daniel M Davis. PLoS Comp. Biol. 7(8): e1002076. doi:10.1371/journal.pcbi.1002076.
• Springs, clutches and motors: driving forward kinetochore mechanism by modelling. Elina Vladimirou, Ed Harry, Nigel Burroughs, Andrew D. McAinsh. Chromosome Research 2011 Apr;19(3):409-21. via PUBMED.
• Inferring the time-invariant topology of a non-linear sparse gene regulatory network using fully Bayesian spline autoregression. Edward R. Morrissey, Miguel A Juarez, Katherine J Denby, Nigel J Burroughs. Biostatistics, (2011) 12(4): 682-694.

• Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies. Moore, J., Jironkin, A., Chandler, D., Burroughs, N., Evans, D.J. and Ryabov, E. J. Gen. Virol. 92 (2011), 156-161.

• Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells. Karsten Kohler, Shiqiu Xiong, Joanna Brzostek, Maryam Mehrabi, Philipp Eissmann, Alice Harrison, Shaun-Paul Cordoba, Stephane Oddos, Vladimir Miloserdov, Keith Gould, Nigel J. Burroughs, P. Anton van der Merwe, Daniel M. Davis. PLoS ONE 5(11): e15374. doi:10.1371/journal.pone.0015374.

• On reverse engineering gene interaction networks using time course data with repeated measurements. E.R. Morrissey, MA. Juárez, KJ Denby, NJ Burroughs. Bioinformatics, 2010, 26;2305--12.

• The dynamic architecture of the metabolic switch in Streptomyces coelicolor. Nieselt, et al. BMC Genomics 11 (2010) 10.

• An improved strip FRAP method for estimating diffusion coefficients: correcting for the degree of photobleaching. J. Yang, K. Kohler, D.M. Davis, N.J. Burroughs. J. Microscopy 2009, 238; 240-253. doi:10.1111/j.1365-2818.2009.03347.x

• Transformation from Spots to Waves in a Model of Actin Pattern Formation. Stephen Whitelam, Till Bretschneider, and Nigel J. Burroughs. PRL. 102, 2009, 198103.

• The expression of recombinant genes in Escherichia coli can be strongly stimulated at the transcript production level by mutating the DNA-region corresponding to the 5’-untranslated part of mRNA. Laila Berg, Rahmi Lale, Ingrid Bakke, N.J. Burroughs and Svein Valla. Microbial Biotechnology. 2 (2009) 379--389.

• Evidence for the intense exchange of MazG in marine cyanophages by horizontal gene transfer. Michael J. Bryan, Nigel J. Burroughs, Edward M. Spence, Martha R. J. Clokie, Nicholas H. Mann and Samantha J. Bryan. PLOS ONE. 3(4): e2048. doi:10.1371/journal.pone.0002048

• Nonequilibrium-Driven Motion in Actin Networks: Comet Tails and Moving Beads. Physical Review Letters. 98, 2007, (issue 23) 238302. N. J. Burroughs and D. Marenduzzo.

• Stochasticity and spatial heterogeneity in TCR activation. NJ Burroughs and PA van der Merwe.
  Immunological Reviews, (2007), 216: 69-80.

• Close contact fluctuations: the seeding of signalling domains in the immunological synapse.
  A.K. Chattopadhyay and N.J. Burroughs. EPL. 77, (2007), 48003

• A Markov Chain Monte Carlo Method for Estimating Population Mixing Using Y-chromosome Markers:
  Mixing of the Han People in China. H. Jow, W. Amos, H. Luo, Y. Zhang and N. J. Burroughs. Annals of Human Genetics (2007) 71,407-420.

• Ligand detection and discrimination by spatial relocalisation: a kinase-phosphatase segregation model of TCR activation. NJ. Burroughs, Z. Lazic, PA van der Merwe. (2006) BJ, 91: 1619-1629.

• T cell activation: a queueing theory analysis at low agonist density. Janak Wedagedera and N.J. Burroughs. (2006) BJ, 91: 1604-1618.

• Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses. [PDF]
  N.J. Burroughs, Bruno Miguel Paz Mendes de Oliveira, Alberto Adrego Pinto. (2006) JTB. 241: 134-141.

• Growth of a semi-flexible polymer close to a fluctuating obstacle: application to cytoskeletal actin fibers and testing of rachet models. NJ. Burroughs and D. Marenduzzo. J. Phys: Condens. matter. (2006). 18:S357-S374.

• Three dimensional dynamic Monte-Carlo simulations of polymer ratchets.
  NJ. Burroughs and D. Marenduzzo. Journal of Chemical Physics. 23, 174908 (2005). [PDF]

• Discriminating self from nonself with short peptides from large proteomes. N.J. Burroughs, Can Kesmir and Rob de Boer. (2004). Immunogenetics. 56, 311--320.

• Interactions between Salmonella typhimurium and Acanthamoeba polyphaga, and observation of a new mode of intracellular growth within contractile vacuoles. William H Gaze, Nigel Burroughs, Maurice P Gallagher and Elizabeth MH Wellington. Microbial. Ecol. 46 (2003) 358--369.

• Perturbation theory analysis of competition in a heterogeneous population.
  C. Utzny and NJ Burroughs. Physica D 175 (2003) 109--126.

• Interface accumulation of receptor/ligand couples in lymphocyte activation: Methods, mechanisms and significance. Immunological Reviews, 189 (2002) 64-83. C. Wulfing, I. Tskvitaria-Fuller, N.J. Burroughs, M.D. Sjaastad, J. Klem and J.D. Schatzle.

• Differential segregation in a cell:cell contact interface - the formation of the immunological synapse. Biophysical Journal, 83 (2002), 1784-1796. N.J. Burroughs and C. Wulfing.

• Quantifying the strength of ligand antagonism in TCR triggering. Bulletin of Mathematical Biology, 64 (2002) 781-808. H.A. van den Berg, N.J. Burroughs & D.A. Rand.

• TCR dynamics on the surface of living T cells. Int. Imm. 13 (2001) 1525-1532 Benoit Favier, N.J. Burroughs, Lucy Wedderburn, Salvatore Valitutti.

• Long-term stability of Diverse Immunological Memory. Utzny C. and Burroughs N.J. Journal of Theortical Biology, 211 (2001) 393-402.

• Stability of a diverse immunological memory is determined by T-cell population dynamics. Utzny, C. & Burroughs, NJ. Bulletin in Mathematical Biology, 63 (2001), 685-713.

• A reliable and safe T cell repertoire based on low-affinity T cell receptors. J. Theor. Bio. 209; (2001) 465-486. H. van den Berg, D.A. Rand and NJ Burroughs. PDF

• Mathematical Analysis of Growth and Interaction Dynamics of Streptomycetes and a Bacteriophage in Soil . Applied & Environmental Microbiology, 66 (2000), 3868-3877. N.J. Burroughs, P. Marsh, E.M.H. Wellington.

• Defective Deletion Mutant Amplification. Journal of Theoretical Biology, 206 (2000) 449-464. N.J. Burroughs and B. McLeod

• Significance testing of clinical data using virus dynamics models and MCMC. Proceedings of the Royal Society, B266; (1999), 2359-2366. N.J. Burroughs, D. Mutimer, D. Pillay.

• Markov Chain Monte Carlo Analysis of Human Y Chromosome Microsatellites. Proceedings of the National Academy of Sciences, USA 96; (1999) 11916-11921. G. Cooper , N.J. Burroughs, D.A. Rand, D.C. Rubinsztein, W. Amos.

• Dynamics of T-cell Antagonism : Enhanced Viral Diversity and Survival. Proceedings of the Royal Society: Biological Sciences (1998) 265, 529-535. N.J. Burroughs, D.A. Rand.