Dr. Katherine Denby
University of Warwick
Tel: +44 (0)24 7657 5097 (HRI) and +44 (0)24 7655 0251 (WSB)
My main research interests are plant signalling mechanisms mediating responses to biotic and abiotic stress, and the downstream responses underlying plant defence and adaptation to environmental stress. I am interested in applying and integrating different "omics" techniques for functional analysis of gene products and plant processes at a systems level.
One current project is investigating how plants respond to infection with the plant pathogen Botrytis cinerea. There is natural variation in the model plant Arabidopsis thaliana for susceptibility to B. cinerea and different isolates of Botrytis cause different degrees of lesion development on the host plant. A significant fraction of this virulence variation is determined by the sensitivity of a given Botrytis isolate to Arabidopsis secondary metabolites. We are profiling gene expression and metabolites and integrating these data sets with pathogen susceptibility information to begin to elucidate how the plant responds to Botrytis infection at multiple levels.
My Botrytis-Arabidopsis research forms part of the BBSRC/EPSRC grant "Elucidating Signalling Networks in Plant Stress Responses"
Kiddle, S.J., Windram, O.P.F., McHattie, S., Mead, A., Beynon, J., Buchanan-Wollaston, V., Denby, K.J. and Mukherjee, S.N. (2010) Temporal clustering by affinity propagation reveals transcriptional modules in Arabidopsis thaliana. Bioinformatics 26(3):355-362
Richard Savage, Katherine Heller, Yang Xu, Zoubin Ghahramani, William M. Truman, Murray Grant, Katherine Denby and David L. Wild. (2009) “R/BHC: Fast Bayesian Hierarchical Clustering for Microarray Data” BMC Bioinformatics 10:242
Lindsay N. Petersen, Robert A. Ingle, Marc R. Knight and Katherine J. Denby. (2009) “OXI1 protein kinase is required for plant immunity against Pseudomonas syringae in Arabidopsis” Journal of Experimental Botany 60(13):3727-3735
Oliver Stegle, Katherine Denby, David L. Wild, Zoubin Ghahramani and Karsten M. Borgwardt. (2009) “A Robust Bayesian Two-Sample Test for Detecting Intervals of Differential Gene Expression in Microarray Time Series” in Research in Computational Molecular Biology, ed. Batzoglou (Springer Berlin, Heidelberg, 2009), Book Series: Lecture Notes in Computer Science 5541:201-216
Murray, S., Ingle, R., Petersen, L. and Denby, K.J. (2007) “Basal resistance against Pseudomonas syringae in Arabidopsis involves WRKY53 and a protein with homology to a nematode resistance protein” Molecular Plant Microbe Interactions 20(11):1431-8
Ingle, R., Carstens, M. and Denby, K.J. (2006) “PAMP recognition and the plant-pathogen arms race” Bioessays 28(9): 880-889
Daniel J. Kliebenstein, Heather C. Rowe and Katherine J. Denby (2005) "Secondary metabolites influence Arabidopsis/Botrytis interactions: variation in host production and pathogen sensitivity" Plant Journal 44: 25-36
Katherine Denby and Chris Gehring (2005) "Engineering drought and salinity tolerance in plants: lessons from genome-wide expression profiling in Arabidopsis" Trends in Biotechnology 23(11): 547-552
Katherine J. Denby, Laure J.M. Jason, Shane L. Murray, and Robert L. Last (2005) "ups1, an Arabidopsis thaliana camalexin accumulation mutant defective in multiple defence signalling pathways" Plant Journal 41:673-684
Donaldson, L.E., Ludidi, N., Knight, M.R., Gehring, C. and Denby, K.J. (2004) "Salt and osmotic stress cause rapid increases in Arabidopsis thaliana cGMP levels." FEBS Letters. Vol 569/1-3 pp 317-320
Denby, K.J., Kumar, P. and Kliebenstein, D.J. (2004) "Identification of Botrytis cinerea susceptibility loci in Arabidopsis thaliana" Plant Journal. 38(3): 473-486
Collett, H., Shen A., Gardner M., Farrant J.M., Denby K.J. and Illing N. (2004) Towards transcript profiling of desiccation tolerance in Xerophyta humilis: Construction of a normalised 11 k X. humilis cDNA set and microarray expression analysis of 424 cDNAs in response to dehydration. Physiologia Plantarum 122: 39-53