Warwick Systems Biology Centre

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Professor David Rand

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David Rand is Professor of Mathematics and directs the Warwick Systems Biology Centre (WSB). He is also an Associate Director of the Warwick BBSRC/EPSRC Systems Biology Doctoral Training Centre. Until August 2005 he was Chair of Warwick's Mathematics Institute. He currently holds an EPSRC Senior Research Fellowship.

Currently, his main research interest is Systems Biology, particularly understanding the design principles of regulatory and signalling systems in cells, but he also still publishes in Dynamical Systems.

Contact
David Rand:	phone: 44(0)24 7652 3599
	email: d.a.rand(at)warwick.ac.uk
PA:	phone: 44(0)24 7652 8321
	fax: 44(0)24 7652 4182
	email: j.a.maynard(at)warwick.ac.uk

News:

New book by Pinto, Rand and Ferreira now available from Springer:

A A. Pinto, D A. Rand and F Ferreira, Fine Structures of Hyperbolic Diffeomorphisms, Springer Monographs in Mathematics ISSN 1439-7382 (published October 22nd, 2008). Book web page here. Flyer

On surfaces the theory of the fine scale structure of hyperbolic invariant sets and their measures can be described in a very complete and elegant way. This is the subject of this book. A very substantial part of the exposition is the outcome of the ongoing research programme of Pinto & Rand that was started in the mid-90s. There are also a number of new developments in the book such as the pseudo-smooth structures for pseudo-Anosov systems.

Some recent papers now available.

Modelling the photoperiod switch in plants predicts new role for FKF1.

J. D. Salazar, T. Saithong, P. E. Brown, J. Foreman, J. C. W. Locke, K. J. Halliday, I. A. Carre, D. A. Rand and A. J. Millar. Prediction of Photoperiodic Regulators from Quantitative Gene Circuit Models. Cell 139, 1170–1179, DOI 10.1016/j.cell.2009.11.029

Stimulation frequency modulates differential gene expression by NF-kappaB; IkappaBepsilon feedback regulates heterogeneithy of oscillations; and the structure and role of A20 feedback is predicted.

L. Ashall, C.A. Horton, D.E. Nelson, P. Paszek, C.V. Harper, K. Sillitoe, S. Ryan, D.G. Spiller, J.F. Unitt, D.S. Broomhead, D.B. Kell, D.A. Rand, V. Sée, and M.R.H. White. Pulsatile stimulation determines timing and specificity of NF-kappa B-dependent transcription. Science 324 (2009) 242-246

M. Komorowski, B. Finkenstadt, C. V. Harper and D. A. Rand. Bayesian inference of biochemical kinetic parameters using the linear noise approximation. (2009) BMC Bioinformatics (to appear)
B. Smith, C. Hill, L. Godfrey, D A Rand, H van den Berg, S Thornton, M Hodgkin, J Davey and G Ladds. Dual positive and negative regulation of GPCR signaling by GTP Hydrolysis. Cellular Signalling 21 (209)1151-1160 doi:10.1016/j.cellsig.2009.03.004
J.D. Salazar, J. Foreman, I.A. Carre, D.A. Rand and A. J. Millar. Mathematical Model of the Epigenetic Control of Vernalisation in Arabidopsis thaliana. Acta Horticulturae Number 803, November 2008
B Finkenstädt, E A. Heron, M Komorowski, K Edwards, S Tang, C V Harper, A J Millar, J R E Davis, M R H White and D A Rand, Reconstruction of transcriptional dynamics from gene reporter data using differential equations. Bioinformatics 2008; doi: 10.1093/bioinformatics/btn562. Download paper. Download Supplementary Information
D. A. Rand. Mapping the global sensitivity of cellular network dynamics: Sensitivity heat maps and a global summation law. J. R. Soc. Interface (2008) doi:10.1098/rsif.2008.0084.focus. Download paper. Download supplementary information.
O. E. Akman, J.C.W. Locke, S. Tang, I. Carré, A. J. Millar & D. A. Rand, Global temperature compensation and extended functionality for the Neurospora crassa circadian clock. Molecular Systems Biology. 4 http://www.nature.com/doifinder/4100210 on 12/02/08 doi: 4100210 Download paper. Download corrigendum. Download supplementary information.
Heron E., Finkenstadt B., Rand D. Statistical inference for delayed transcriptional gene regulation, an application to the Hes1 system,. Bioinformatics. doi: 10.1093/bioinformatics/btm367 Download paper. Download supplementary information.
A. A. Pinto, D. A. Rand & F. Ferreira, Cantor exchange systems and renormalization. Journal of Differential Equations 243(2) (2007) 593-616.
A. A. Pinto, D. A. Rand & F. Ferreira, Hausdorff dimension bounds for smoothness of holonomies for codimension one hyperbolic dynamics. Journal of Differential Equations 243(2) (2007) 168-178.
H van den Berg & D. A. Rand, Quantitative theories of T cell responsiveness. Immunological Reviews. 216(1) (2007) 81-92. Download.
A Pinto & D. A. Rand, Solenoid functions for hyperbolic sets on surfaces. In: Dynamics, Ergodic Theory, and Geometry: Dedicated to Anatole Katok (ed. Boris Hasselblatt). Mathematical Sciences Research Institute Publications, Cambridge University Press (2007) 145-178.

Available now: new global sensitivity analysis tools developed by Paul Brown and David Rand. These enable one to calculate and display the sensitivity heat maps and parameters sensitivity spectrum introduced recently by David Rand. The software is driven bt three GUIs and at the moment only works for oscillators. In the near future it will be augmented so that it also works for signalling systems where the solution of interest is a transcient that is excited by an incoming signal. On the download page you just click on the file called Limit Cycle Sensitivity Analysis. Download.

Older clocks software available. This is older stuff produced by Paul Brown, Boris Shulgin and David Rand. Download.

PhD studentships available from BBSRC/EPSRC Systems Biology Doctoral Training Centre for students with a mathematical or physical sciences background or a biological one. To find out more contact Vicky Buchanan-Wollaston (vicky.b-wollaston@warwick.ac.uk) who directs the DTC. More ...