Title. Integrative genomics of ageing - New approaches for an old problem

Summary. Ageing is the major biomedical challenge of the 21^st century, yet it remains largely mysterious, partly because the ageing process involves multiple genes and their interactions with each other and with the environment that remain poorly understood. In this talk, I will present our work in helping decipher the genome and how it regulates complex processes like ageing. I will discuss genome-wide approaches, including RNA-seq and computational analyses, that can be used to infer the function of mammalian genes and increase our knowledge of how genes and pathways impact on ageing. Moreover, I will present a systems biology dissection of caloric restriction, a dietary manipulation of ageing, to gather insights into its regulation and identify promising drug targets. Lastly, I will present our studies of genome evolution to understand how different genomes can give rise to species which marked differences in rate of ageing.